Differentiation of innate lymphoid cells
| Project/Area Number |
26293110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kazuyo Moro 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (90468489)
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| Co-Investigator(Renkei-kenkyūsha) |
Ikawa Tomokatsu 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (60450392)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ILC2 / 分化 / ストローマ細胞 / Notch / 自然リンパ球 / ILC2s / ナチュラルヘルパー細胞 / IL-7 |
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| Outline of Final Research Achievements |
In this project, we found that the concentration of IL-7 differentially regulates T cell and ILC2 differentiation. Furthermore, to clarify the microenvironment that supports ILC2 development, we identified ILC progenitors and immature ILC2 in the fetal mesentery. We also showed by transplantation analysis that mesentery functions as a site that induces differentiation of mature ILC2.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.2015
Author(s)
Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
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Journal Title
Immunity
Volume: 43
Issue: 1
Pages: 175-86
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.2015
Author(s)
Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A
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Journal Title
Nat Immunol.
Volume: 16
Issue: 3
Pages: 276-285
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation.2014
Author(s)
Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M
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Journal Title
Immunity
Volume: 40
Issue: 5
Pages: 758-771
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 2型自然リンパ球の役割2016
Author(s)
茂呂和世
Organizer
第44回日本臨床免疫学会総会
Place of Presentation
東京都新宿区京王プラザホテル
Year and Date
2016-09-08
Related Report
Invited
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[Book] 細胞工学2015
Author(s)
加畑宏樹、茂呂和世、別役智子、小安重夫
Total Pages
5
Publisher
学研メディカル秀潤社
Related Report
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[Book] 炎症と免疫2015
Author(s)
本村泰隆、茂呂和世、小安重夫
Total Pages
7
Publisher
先端医学社
Related Report
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[Book] 医学のあゆみ2015
Author(s)
加畑 宏樹, 茂呂 和世
Total Pages
6
Publisher
医歯薬出版株式会社
Related Report
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