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Differentiation of innate lymphoid cells

Research Project

Project/Area Number 26293110
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Immunology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kazuyo Moro  国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (90468489)

Co-Investigator(Renkei-kenkyūsha) Ikawa Tomokatsu  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (60450392)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
KeywordsILC2 / 分化 / ストローマ細胞 / Notch / 自然リンパ球 / ILC2s / ナチュラルヘルパー細胞 / IL-7
Outline of Final Research Achievements

In this project, we found that the concentration of IL-7 differentially regulates T cell and ILC2 differentiation. Furthermore, to clarify the microenvironment that supports ILC2 development, we identified ILC progenitors and immature ILC2 in the fetal mesentery. We also showed by transplantation analysis that mesentery functions as a site that induces differentiation of mature ILC2.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (40 results)

All 2017 2016 2015 2014 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 6 results,  Open Access: 2 results) Presentation (23 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results) Book (8 results) Remarks (2 results)

  • [Journal Article] Innate lymphoid cells in allergic and nonallergic inflammation.2016

    • Author(s)
      Morita H, Moro K, Koyasu S.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 138(5) Issue: 5 Pages: 1253-1264

    • DOI

      10.1016/j.jaci.2016.09.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interferon and interleukin-27 antagonize group 2 innate lymphoid cell function and type 2 innate immune responses.2016

    • Author(s)
      Moro K, Kabata H, Tanabe M, Koga S, Takeno N, Mochizuki M, Fukunaga K, Asano K, Betsuyaku T, Koyasu S.
    • Journal Title

      Nature Immunology.

      Volume: 17(1) Issue: 1 Pages: 76-86

    • DOI

      10.1038/ni.3309

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: 43 Issue: 1 Pages: 175-86

    • DOI

      10.1016/j.immuni.2015.06.021

    • NAID

      40020962854

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Isolation and analysis of group 2 innate lymphoid cells in mice.2015

    • Author(s)
      Moro K, Ealey KN, Kabata H, Koyasu S
    • Journal Title

      Nat Protoc.

      Volume: 10 Issue: 5 Pages: 792-806

    • DOI

      10.1038/nprot.2015.047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Innate lymphoid cells, possible interaction with microbiota.2015

    • Author(s)
      Moro K, Koyasu S
    • Journal Title

      Semin Immunopathol.

      Volume: 37 Issue: 1 Pages: 27-37

    • DOI

      10.1007/s00281-014-0470-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.2015

    • Author(s)
      Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A
    • Journal Title

      Nat Immunol.

      Volume: 16 Issue: 3 Pages: 276-285

    • DOI

      10.1038/ni.3085

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation.2014

    • Author(s)
      Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M
    • Journal Title

      Immunity

      Volume: 40 Issue: 5 Pages: 758-771

    • DOI

      10.1016/j.immuni.2014.04.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Group 2 innate lymphoid cell and allergic inflammation2017

    • Author(s)
      Kazuyo Moro
    • Organizer
      Advances in Targeted Therapies Meeting
    • Place of Presentation
      Hottel Pulman,Mandelieu France
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ILC2をターゲットとした喘息治療の展望2016

    • Author(s)
      茂呂和世
    • Organizer
      第53回日本小児アレルギー学会第
    • Place of Presentation
      群馬県高崎市ホテルメトロポリタン
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 2型自然リンパ球の役割2016

    • Author(s)
      茂呂和世
    • Organizer
      第44回日本臨床免疫学会総会
    • Place of Presentation
      東京都新宿区京王プラザホテル
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Suppression mechanism of2016

    • Author(s)
      Kazuyo Moro
    • Organizer
      FASEB
    • Place of Presentation
      Marriott Hottel,Florida.USA
    • Year and Date
      2016-07-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ILC2による好酸球性炎症誘導機構2016

    • Author(s)
      茂呂和世
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京都千代田区東京国際フォーラム
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Group 2 ILCの抑制機構2016

    • Author(s)
      茂呂和世、小安重夫
    • Organizer
      第25回 Kyoto T Cell Conference
    • Place of Presentation
      京都府京都市平安会館
    • Year and Date
      2016-05-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IFNとIL-27による2型自然リンパ球の抑制2016

    • Author(s)
      茂呂和世
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪府大阪市大阪国際交流センター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Interferon and IL-27 antagonize ILC2 function and type 2 innate immune responses2016

    • Author(s)
      茂呂和世
    • Organizer
      第9回寄生虫感染免疫研究会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2016-02-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Group 2 Innate lymphoid cell: アレルギー性疾患の新しいターゲット2016

    • Author(s)
      茂呂和世
    • Organizer
      第34回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      三重県鳥羽市鳥羽国際ホテル
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 自然リンパ球とアレルギー2015

    • Author(s)
      茂呂和世
    • Organizer
      第2回 総合アレルギー講習会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肥満における2型自然リンパ球の役割2015

    • Author(s)
      茂呂和世
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市神戸ポートピアホテル
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Interferon and IL-27 antagonize ILC2 function and type 2 innate immune responses2015

    • Author(s)
      Kazuyo Moro
    • Organizer
      Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自然リンパ球の寄生虫排除機構2015

    • Author(s)
      茂呂和世
    • Organizer
      第158回 日本獣医学会学術集会
    • Place of Presentation
      青森県十和田市北里大学
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肥満における制御性T細胞と2型自然リンパ球の役割2015

    • Author(s)
      茂呂和世
    • Organizer
      日本肥満学会第20回アディポサイエンスシンポジウム
    • Place of Presentation
      大阪府大阪市千里ライフサイエンスセンター
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] グループ2自然リンパ球とアレルギー-ILC2をいかにして抑制するか-2015

    • Author(s)
      加畑宏樹、茂呂和世、別役智子、小安重夫
    • Organizer
      第52回日本消化器免疫学会総会
    • Place of Presentation
      東京都新宿区京王プラザホテル
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 自然リンパ球とアレルギー2014

    • Author(s)
      茂呂和世
    • Organizer
      日本アレルギー学会 第1回総合アレルギー講習会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Innate lymphoid cells and inflammation2014

    • Author(s)
      Kazuyo Moro
    • Organizer
      Annual Meeting of The Japanese Society for Immunology, 2014
    • Place of Presentation
      京都
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] アレルギー・生活習慣病・肥満克服の新しいターゲット2014

    • Author(s)
      茂呂和世
    • Organizer
      未病社会の診断技術研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] アレルギー疾患の悪化メカニズム2014

    • Author(s)
      茂呂和世
    • Organizer
      第51回日本小児アレルギー学会
    • Place of Presentation
      四日市市
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Group 2 innate lymphoid cells and allergy2014

    • Author(s)
      茂呂和世
    • Organizer
      第51回日本小児アレルギー学会
    • Place of Presentation
      四日市市
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナチュラルヘルパー細胞と慢性炎症2014

    • Author(s)
      茂呂和世
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナチュラルヘルパー細胞とTh2型関連疾患2014

    • Author(s)
      茂呂和世
    • Organizer
      BD学術セミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナチュラルヘルパー細胞とTh2型疾患2014

    • Author(s)
      茂呂和世
    • Organizer
      第38回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Book] アレルギー・免疫2016

    • Author(s)
      加畑宏樹、茂呂和世、別役智子
    • Total Pages
      8
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞工学2015

    • Author(s)
      加畑宏樹、茂呂和世、別役智子、小安重夫
    • Total Pages
      5
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2015 Annual Research Report
  • [Book] 炎症と免疫2015

    • Author(s)
      本村泰隆、茂呂和世、小安重夫
    • Total Pages
      7
    • Publisher
      先端医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 臨床免疫・アレルギー科2015

    • Author(s)
      茂呂和世、加畑宏樹、小安重夫
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report
  • [Book] アレルギー2015

    • Author(s)
      加畑 宏樹, 茂呂 和世, 小安 重夫, 浅野 浩一郎
    • Total Pages
      11
    • Publisher
      日本アレルギー学会
    • Related Report
      2014 Annual Research Report
  • [Book] 医学のあゆみ2015

    • Author(s)
      加畑 宏樹, 茂呂 和世
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学増刊2014

    • Author(s)
      本村泰隆、茂呂和世、小安重夫
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床・アレルギー科2014

    • Author(s)
      加畑宏樹、浅野浩一郎、茂呂和世、小安重夫
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.ims.riken.jp/labo/56/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 理化学研究所 統合生命医科学研究センター

    • URL

      http://www.ims.riken.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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