Development of new diagnostic method for dementia by fusion of PET and NIRS
| Project/Area Number |
26293133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Tohoku University |
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Principal Investigator |
WATABE HIROSHI 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
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| Co-Investigator(Kenkyū-buntansha) |
田代 学 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Hitoshi 福島県立医科大学, 先端臨床研究センター, 教授 (00325292)
WATANUKI Seiichi (MIYAKE Masayasu) 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (30210967)
SHIDAHARA Miho 東北大学, 医学系研究科, 講師 (20443070)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 医学物理 / PET / NIRS / アミロイド / 放射線 / 脳神経疾患 |
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| Outline of Final Research Achievements |
In order to dramatically improve the diagnostic ability of Alzheimer's disease, this study aims to develop a new diagnostic method for PET amyloid β imaging agent and construct a fusion system of PET image and NIRS data. Based on the chemical form of the agent, we could predicted PET data for sevral PET amyloid pharmaceuticals, and derived CUI (clinical usefulness index) to evaluate its diagnostic ability. We also developed a PET/NIRS fusion system using an optical tracking device and evaluated its effectiveness by clinical experiments. As a result, PET and NIRS data were displayed in the same coordinate system in the brain, and analysis of both modalities could be merged.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.2017
Author(s)
Arakawa Y, Nai Y, Shidahara M, Furumoto S, Seki C, Okamura N, Tashiro M, Kudo Y, Yanai K, Gonda K, Watabe H.
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Journal Title
J Nucl Med.
Volume: -
Issue: 8
Pages: 1285-1292
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain.2015
Author(s)
Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
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Journal Title
Nucl Med Biol.
Volume: 42
Issue: 9
Pages: 734-744
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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