Pathological elucidation of age-related diseases by integrative analyses of senescence genes

• Project/Area Number: 26293165
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Chiba University
• Principal Investigator: Yokote Koutaro 千葉大学, 医学(系)研究科(研究院), 教授 (20312944)
• Co-Investigator(Kenkyū-buntansha): 清水 孝彦 千葉大学, 医学(系)研究科(研究院), 准教授 (40301791) ; 竹本 稔 千葉大学, 医学(系)研究科(研究院), 准教授 (60447307)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 老年医学 / 老化 / 遺伝子 / 早老症 / ウェルナー

Outline of Final Research Achievements

Werner syndrome (WS) is progeroid syndrome and is caused by the recessive mutation of WRN gene. WS patients exhibit accelerated telomere shortening. However, Wrntm1Lgu, TercG4/G4 double-null mice have failed to deteriorate pathologies of Wrntm1Lgu single-null mice. In this study, to reconfirm pathological significance of telomere in a WS model, we generated Wrntm1Lgu, Terttm1Fish double-null mice and intercrossed those mice until G4 generation (TertG4/G4) to induce telomere shortening. Although both TertG4/G4 or Wrn-/-, TertG4/G4 double null mice showed significant shortening of telomere length in various organs, Wrn-/-, TertG4/G4 mice were grown without apparent abnormality in muscle, liver as well as bone. However, Wrn-/-, TertG4/G4 mice only deteriorated fat atrophy in skin and testis degeneration, but not epidermis and dermis atrophies. These results suggested that the telomere shortening by Tert deficiency is in part attributable to premature aging pathologies in WS models.

Research Products

• [Journal Article] Recent trends in WRN gene mutation patterns in individuals with Werner syndrome. (2017)
  • Author(s): Yamaga M, Takemoto M, Takada-Watanabe A, Koizumi N, Kitamoto T, Sakamoto K, Ishikawa T, Koshizaka M, Maezawa Y, Yokote K
  • Journal Title: J Am Geriatr Soc Volume: 印刷中 Issue: 8 Pages: 1853-1856
  • DOI: 10.1111/jgs.14906
  • Peer Reviewed / Open Access
• [Journal Article] Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction. (2017)
  • Author(s): Ide K, Baba Y, Takemoto M, Koide H, Ide S, Yamaga M, Kobayashi K, Yokote K.
  • Journal Title: Geriatr Gerontol Int Volume: 17 Issue: 2 Pages: 346-347
  • DOI: 10.1111/ggi.12809
  • Peer Reviewed / Open Access
• [Journal Article] WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. (2017)
  • Author(s): Yokote K, Chanprasert S, Lee L, Eirich K, Takemoto M, Watanabe A, Koizumi N, Lessel D, Mori T, Hisama FM, Ladd PD, Angle B, Baris H, Cefle K, Palanduz S, Ozturk S, Chateau A, Deguchi K, Easwar TK, Federico A, Fox A, Grebe TA, Hay B, Nampoothiri S, Seiter K, Streeten E, Poke G, Poot M, Posmyk R, Oshima J
  • Journal Title: Hum Mutat Volume: 38 Issue: 1 Pages: 7-15
  • DOI: 10.1002/humu.23128
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The obesity-related pathology and Th17 cells. (2017)
  • Author(s): Endo, Y., Yokote, K., and Nakayama, T.
  • Journal Title: Cell. Mol. Life Sci. Volume: 74 Issue: 7 Pages: 1231-1245
  • DOI: 10.1007/s00018-016-2399-3
  • NAID: 40021094104
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Balfour Sartor, John P Iredale, Jack Satsangi. MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. (2017)
  • Author(s): Gwo-Tzer Ho, Rhona E Aird, Bo Liu, Nicholas A Kennedy, David A Dorward, Colin L Noble, Takahiko Shimizu, Nicholas M Morton, Adriano G Rossi, R. Balfour Sartor, John P Iredale, Jack Satsangi.
  • Journal Title: Mucosal Immunology Volume: - Issue: 1 Pages: 120-130
  • DOI: 10.1038/mi.2017.31
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice. (2017)
  • Author(s): Oyama, J.*, Shirakihara, A., Nishikido, T., Maeda, T., Komoda, H., Shimizu, T., Makino, N., Node, K.
  • Journal Title: J Cardiol. Volume: 69 Issue: 2 Pages: 417-427
  • DOI: 10.1016/j.jjcc.2016.05.019
  • Peer Reviewed / Open Access
• [Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice. (2017)
  • Author(s): Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
  • Journal Title: Neurosci Lett Volume: 642 Pages: 123-128
  • DOI: 10.1016/j.neulet.2017.02.003
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. (2016)
  • Author(s): Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 13683-13683
  • DOI: 10.1038/ncomms13683
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Case of sarcomatoid carcinoma occurring in a patient with Werner syndrome. (2016)
  • Author(s): Mitamura Y, Azuma S, Matsumoto D, Takada-Watanabe A, Takemoto M, Yokote K, Motoshita J, Oda Y, Furue M, Takeuchi S
  • Journal Title: J Dermatol Volume: 43 Issue: 11 Pages: 1362-1364
  • DOI: 10.1111/1346-8138.13399
  • Peer Reviewed / Open Access
• [Journal Article] Real-world evidence for the safety of ipragliflozin in elderly Japanese patients with type 2 diabetes mellitus (STELLA-ELDER): final results of a post-marketing surveillance study. (2016)
  • Author(s): Yokote K, Terauchi Y, Nakamura I, Sugamori H.
  • Journal Title: Expert Opin Pharmacother Volume: 17 Issue: 15 Pages: 1995-2003
  • DOI: 10.1080/14656566.2016.1219341
  • Peer Reviewed / Open Access
• [Journal Article] Improved Glycemic Control and Vascular Function and Reduction of Abdominal Fat Accumulation with Liraglutide in a Case of Werner Syndrome with Diabetes Mellitus. (2016)
  • Author(s): Ide S, Yamamoto M, Takemoto M, Fujimoto M, Ide K, Kobayashi K, Yokote K.
  • Journal Title: J Am Geriatr Soc Volume: 64 Issue: 3 Pages: 687-688
  • DOI: 10.1111/jgs.13970
  • Peer Reviewed / Open Access
• [Journal Article] Matricellular protein CCN3 mitigates abdominal aortic aneurysm. (2016)
  • Author(s): Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z
  • Journal Title: J Clin Invest Volume: 126 Issue: 4 Pages: 1282-1299
  • DOI: 10.1172/jci82337
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation. (2016)
  • Author(s): Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Shimizu, T., Jae Youl Cho, Dae Bang Seo*, Song Seok Shin*.
  • Journal Title: J. Ginseng Res. Volume: - Issue: 3 Pages: 277-283
  • DOI: 10.1016/j.jgr.2016.05.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis (2016)
  • Author(s): Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 29038-29038
  • DOI: 10.1038/srep29038
  • NAID: 120005774689
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop. (2015)
  • Author(s): Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
  • Journal Title: J Clin Endocrinol Metab. Volume: 101(3) Issue: 3 Pages: 841-846
  • DOI: 10.1210/jc.2015-2855
  • Peer Reviewed / Open Access
• [Journal Article] Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes. (2015)
  • Author(s): Shoji M, Kobayashi K, Takemoto M, Sato Y, Yokote K.
  • Journal Title: Biomarkers Volume: 21(2) Issue: 2 Pages: 164-167
  • DOI: 10.3109/1354750x.2015.1118551
  • Peer Reviewed / Open Access
• [Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. (2015)
  • Author(s): Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
  • Journal Title: Sci Rep Volume: 30 Issue: 1 Pages: 17565-17565
  • DOI: 10.1038/srep17565
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries. (2015)
  • Author(s): Sakamoto K, Kuno K, Takemoto M, He P, Ishikawa T, Onishi S, Ishibashi R, Okabe E, Shoji M, Hattori A, Yamaga M, Kobayashi K, Kawamura H, Tokuyama H, Maezawa Y, Yokote K
  • Journal Title: J Diabetes Res Volume: 印刷中 Pages: 727152-727152
  • DOI: 10.1155/2015/727152
  • Peer Reviewed / Open Access
• [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns (2015)
  • Author(s): Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
  • Journal Title: J Eat Disord Volume: 3 Issue: 1 Pages: 14-14
  • DOI: 10.1186/s40337-015-0050-6
  • Peer Reviewed / Open Access
• [Journal Article] Germline deletion of ARMC5 in familial primary macronodular adrenal hyperplasia. Endocr Pract. (2015)
  • Author(s): Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T.
  • Journal Title: Endocr Pract Volume: 21(10) Pages: 1152-1160
  • Open Access
• [Journal Article] Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. (2015)
  • Author(s): Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T
  • Journal Title: Cell Rep Volume: 12 Issue: 6 Pages: 1042-1055
  • DOI: 10.1016/j.celrep.2015.07.014
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis. (2015)
  • Author(s): Kobayashi K1, Nojiri H2, Saita Y2, Morikawa D1, Ozawa Y3, Watanabe K3, Koike M1, Asou Y4, Shirasawa T5, Yokote K6, Kaneko K2, Shimizu T3.
  • Journal Title: Scientific Reports Volume: Mar 16;5 Issue: 1 Pages: 9148-9148
  • DOI: 10.1038/srep09148
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration (2015)
  • Author(s): Koike, M., Nojiri, H., Ozawa, Y., Watanabe, K., Muramatsu, Y., Kaneko, H., Morikawa, D., Kobayashi, K., Saita, Y., Sasho, T., Shirasawa, T., Yokote, K., Kaneko, K., Shimizu, T.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 11722-11722
  • DOI: 10.1038/srep11722
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of serum antibody levels against TUBB2C with diabetes and cerebral infarction. (2015)
  • Author(s): Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa I, et al.
  • Journal Title: Gratis J Biomed Sci Volume: 1(2) Issue: 2 Pages: 49-63
  • DOI: 10.18314/gjbs.v1i2.27
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus. (2015)
  • Author(s): Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E, Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, et al
  • Journal Title: J. Mol. Biomark. Diagnos. Volume: 6 Issue: 02 Pages: 2-2
  • DOI: 10.4172/2155-9929.1000219
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pioglitazone improves fat tissue distribution and hyperglycemia in Cockayne syndrome with diabetes. (2015)
  • Author(s): Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K.
  • Journal Title: Diabetes Care. Volume: 38(5) Issue: 5 Pages: e76-e76
  • DOI: 10.2337/dc14-2944
  • Peer Reviewed / Open Access
• [Journal Article] Astaxantin improved non-alcoholic fatty liver disease in Werner syndrome with diabetes. (2015)
  • Author(s): Takemoto M, Tamaga M, Furuichi Y, Yokote K.
  • Journal Title: J Am Geriatr Soc. Volume: 63(6) Issue: 6 Pages: 1271-1273
  • DOI: 10.1111/jgs.13505
  • Open Access
• [Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone (SUCCESS-1): a multicenter, randomized, open-label, non-inferiority trial. (2015)
  • Author(s): Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K; SUCCESS Study Group
  • Journal Title: Journal of Diabetes Invest Volume: 6(2) Issue: 2 Pages: 182-191
  • DOI: 10.1111/jdi.12282
  • Peer Reviewed / Open Access
• [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma. (2015)
  • Author(s): Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
  • Journal Title: Leuk Lymphoma. Volume: 印刷中 Issue: 10 Pages: 1-4
  • DOI: 10.3109/10428194.2015.1016930
  • Peer Reviewed / Open Access
• [Journal Article] Mutation in Insulin Receptor Attenuates Oxidative Stress and Apoptosis in Pancreatic Beta-Cells Induced by Nutrition Excess: Reduced Insulin Signaling and ROS. (2015)
  • Author(s): Tachibana K, Sakurai K, Yokoh H, Ishibashi T, Ishikawa K, Shirasawa T, Yokote K.
  • Journal Title: Horm Metab Res. Volume: 47(3) Issue: 03 Pages: 176-183
  • DOI: 10.1055/s-0034-1389990
  • Open Access
• [Journal Article] Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice. (2015)
  • Author(s): Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, Iwama A.
  • Journal Title: Leuk Lymphoma. Volume: 56 Issue: 2 Pages: 520-523
  • DOI: 10.3109/10428194.2014.924120
  • Peer Reviewed / Open Access
• [Journal Article] Astaxantin improved non- alcoholic fatty liver disease in Werner syndrome with diabetes. (2015)
  • Author(s): Takemoto M, Yamaga M, Furuichi Y, Yokote K
  • Journal Title: J Am Geriat Soc Volume: 印刷中
• [Journal Article] Pioglitazone improves fat tissue distribution and hyperglycemia in a case of Cockayne syndrome with diabetes. (2015)
  • Author(s): Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K
  • Journal Title: Diabetes Care Volume: 印刷中
• [Journal Article] Helicobacter cinaedi infection in patients with diabetes: A Case report (2015)
  • Author(s): Ishibashi R, Nakamura S, Takemoto M, Mukai C, Yokote Y
  • Journal Title: Springerplus Volume: - Issue: 1 Pages: 72-72
  • DOI: 10.1186/s40064-015-0863-4
  • Peer Reviewed
• [Journal Article] Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes. (2015)
  • Author(s): Maezawa Y, Takemoto M, Yokote K.
  • Journal Title: J Diabetes Investig Volume: 6 Issue: 1 Pages: 3-15
  • DOI: 10.1111/jdi.12255
  • NAID: 120007054435
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with T2DM inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial. (2014)
  • Author(s): Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S,Yokote K, on behalf of the SUCCESS Study Group.
  • Journal Title: Diabetes, Obesity and Metabolism Volume: - Issue: 8 Pages: 761-765
  • DOI: 10.1111/dom.12264
  • Peer Reviewed
• [Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity. (2014)
  • Author(s): Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 5412-5412
  • DOI: 10.1038/srep05412
  • Peer Reviewed / Open Access
• [Journal Article] Is obesity an absolute evil? Increase in adipose tissue does not always decrease insulin sensitivity. (2014)
  • Author(s): Ishikawa K, Yokote K
  • Journal Title: J Diabetes Investig. Volume: 5(3) Issue: 3 Pages: 278-280
  • DOI: 10.1111/jdi.12205
• [Journal Article] Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas. (2014)
  • Author(s): Oshitari T, Kitahashi M, Mizuno S, Baba T, Kubota-Taniai M, Takemoto M, Yokote K, Yamamoto S, Roy S
  • Journal Title: BMC Ophthalmol. Volume: - Issue: 1 Pages: 31-31
  • DOI: 10.1186/1471-2415-14-31
  • Peer Reviewed / Open Access
• [Presentation] 高齢者糖尿病の治療目標 (2017)
  • Author(s): 横手幸太郎
  • Organizer: 第54回日本糖尿病学会関東甲信越地方会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2017-01-22
• [Presentation] Autologous transplantation of gene-transfered adipocytes for treatment of intractable diseases. (2017)
  • Author(s): Yokote, K
  • Organizer: Joint symposium between Taipei Medical University and Chiba Universaity at Taipei Medical University
  • Place of Presentation: Taipei Medical University(Taipei)
  • Invited
• [Presentation] 糖尿病と肥満症：診療と研究の話題から (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン(東京都江東区)
  • Year and Date: 2016-10-07
• [Presentation] 肥満症の治療 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン(東京都江東区)
  • Year and Date: 2016-10-07
• [Presentation] Diet therapy in prevention of atherosclerotic vascular diseases. (2016)
  • Author(s): Yokote, K
  • Organizer: 10th APSAVD Congress APSAVD-IAS-JAS Joint Symposium-Novel therapeutic agents for dyslipidemia
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-16
• [Presentation] 動脈硬化進展抑制を目指した脂質異常症治療 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-15
• [Presentation] 動脈硬化予防のための脂質管理の現状と展望 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-14
• [Presentation] 高齢糖尿病患者における薬物治療と包括的管理 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂(石川県金沢市)
  • Year and Date: 2016-06-10
• [Presentation] 動脈硬化性疾患予防ガイドライン：主として脂質管理の観点から (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂(石川県金沢市)
  • Year and Date: 2016-06-09
• [Presentation] 加齢により発症が促進される疾患メカニズムの解明：ヒト早老モデルに立脚した解析から (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: ANAクラウンプラザホテル(石川県金沢市)
  • Year and Date: 2016-06-08
• [Presentation] Clinical and biological features of Werner syndrome. (2016)
  • Author(s): Yokote, K
  • Organizer: The 3rd International Meeting on RECQ Helicases in Biology and Medicine (RECQ2016)
  • Place of Presentation: Fred Hutchinson Cancer Research(Seattle, USA)) Center
  • Year and Date: 2016-05-28
• [Presentation] 高齢者糖尿病の薬物治療-適切な薬剤選択と低血糖予防を目指した血糖コントロールの考え方 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2016-05-20
• [Presentation] イプラグリフロジンの高齢者における安全性：特定使用成績調査（STELLA-ELDER） (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2016-05-19
• [Presentation] Novel treatment to residual risk, K-877, a selective PPAR α modulator(SPPARM α), added-on to stable pitavastatin treatment in Japanese patients with dyslipidemia. (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-03-18
• [Presentation] Residual riskとしての中性脂肪 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-03-18
• [Presentation] Treat to target strategy in lipid management for prevention of atherosclerotic vascular diseases. (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-03-18
• [Presentation] 肥満症に対する内科的治療 (2016)
  • Author(s): 横手幸太郎
  • Organizer: 第50回日本成人病(生活習慣病)学会学術集会
  • Place of Presentation: 都市センターホテル(東京都千代田区)
  • Year and Date: 2016-01-16
• [Presentation] 高齢者糖尿病治療のUPDATE (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第30回日本糖尿病合併症学会
  • Place of Presentation: 愛知県産業労働センター ウィンクあいち(愛知県名古屋市)
  • Year and Date: 2015-11-27
• [Presentation] Novel approach to residual risk, K-877, a potent and selective PPAR-α Modulator(SPPARMα), added-on to Pitavastatin in Japanese patients with dyslipidemia. (2015)
  • Author(s): Yokote K, Ishibashi S, Yamashita S, Arai H, Araki E, Suganami H, Kodama T.
  • Organizer: American Heart Association Scientific Session 2015
  • Place of Presentation: Orange County Convention Center(Orlando, USA.)
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] 高齢者における糖尿病治療戦略 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第53回日本糖尿病学会東北地方会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2015-11-07
• [Presentation] Establishment of induced pluripotent stem cells derived from progeroid syndrome. (2015)
  • Author(s): Yokote, K
  • Organizer: The 10th International Association of Gerontology and Geriatrics- Asia/Oceania 2015
  • Place of Presentation: The International Convention and Exhibition Center(Chiang Mai, Thailand)
  • Year and Date: 2015-10-19
• [Presentation] Progeroid syndrome as a model of aging,metabolic diseases and cancer. (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第74回日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-10-08
• [Presentation] Targeting obesity in management of diabetes: potential role of incretin-based therapies. (2015)
  • Author(s): Yokote, K
  • Organizer: The 8th Asia-Oceania Conference on Obesity (AOCO 2015)
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-10-04
• [Presentation] 肥満症の治療と管理 (2015)
  • Author(s): 横手幸太郎、徳山宏丈
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-10-02
• [Presentation] 超高齢社会の糖尿病治療戦略 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第16回日本内分泌学会関東甲信越支部学術集会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
  • Year and Date: 2015-09-26
• [Presentation] Diabetes, Obesity and Atherosclerosis. (2015)
  • Author(s): Yokote, K
  • Organizer: The 15th Taipei International Vascular Biology Symposium Plenary Session
  • Place of Presentation: 台湾大学(台湾、中国)
  • Year and Date: 2015-09-13
• [Presentation] Pitavastatin and Incidence of DM. (2015)
  • Author(s): Yokote, K
  • Organizer: The Annual Scientific Meeting of Taiwan Society of Lipids & Atherosclerosis 2015
  • Place of Presentation: 台湾大学(台湾、中国)
  • Year and Date: 2015-09-12
• [Presentation] 健康長寿のための肥満症対策 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第33回日本肥満症治療学会学術集会
  • Place of Presentation: 幕張国際研修センター(千葉県千葉市)
  • Year and Date: 2015-06-27
• [Presentation] 肥満症の総合的治療戦略 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第33回日本肥満症治療学会学術集会
  • Place of Presentation: 幕張国際研修センター(千葉県千葉市)
  • Year and Date: 2015-06-26
• [Presentation] 高齢者糖尿病の薬物療法 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第29回日本老年学会総会・第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2015-06-13
• [Presentation] 脂質異常症の観点から (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2015-05-30
• [Presentation] 脂質異常症治療の展望 (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関(山口県下関市)
  • Year and Date: 2015-05-22
• [Presentation] 高齢者糖尿病の病態とその特徴 (2015)
  • Author(s): 小林一貴、横手幸太郎
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関(山口県下関市)
  • Year and Date: 2015-05-22
• [Presentation] 北欧留学体験記：学問する文化との出会い (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関(山口県下関市)
  • Year and Date: 2015-05-22
• [Presentation] Beyond LDL時代における脂質管理 脂肪酸の役割を含めて (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2015-04-24
• [Presentation] 2型糖尿病への脂質介入Update (2015)
  • Author(s): 横手幸太郎
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2015-04-23
• [Presentation] 肥満pandemic時代の糖尿病合併症予防～外科治療/SGLT2阻害薬への期待と注意点を含めて～ (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: シーガイアコンベンションセンター(宮崎県宮崎市)
  • Year and Date: 2014-10-24
• [Presentation] 安全かつ有効な肥満症外来治療の方向性：関連学会合同委員会の活動を踏まえて (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: シーガイアコンベンションセンター(宮崎県宮崎市)
  • Year and Date: 2014-10-24
• [Presentation] Progeroid syndrome as a model of aging-related metabolic disorders. (2014)
  • Author(s): Yokote, K
  • Organizer: International Conference on Diabetes and Metabolism 2014
  • Place of Presentation: KINTEX Exhibition Center(京畿道 京陽市 韓国)
  • Year and Date: 2014-10-17
• [Presentation] Lipid management in diabetes: potential role of pitavastatin in Asian patients. International Conference on Diabetes and Metabolism. (2014)
  • Author(s): Yokote, K
  • Organizer: International Conference on Diabetes and Metabolism 2014
  • Place of Presentation: KINTEX Exhibition Center(京畿道 京陽市 韓国)
  • Year and Date: 2014-10-06
• [Presentation] Statin in Lipid Management of Diabetes: Effect on Dyslipidemia and Beyond. (2014)
  • Author(s): Yokote, K
  • Organizer: MSDA2014
  • Place of Presentation: 京都国際会館(京都府京都市)
  • Year and Date: 2014-09-14
• [Presentation] スタチン投与の適応を検証する (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第46回日本動脈硬化学会総会 学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2014-07-11
• [Presentation] 動脈硬化のメカニズム・脳心血管病との関係について (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第46回日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2014-07-11
• [Presentation] 日本肥満学会の立場から (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第32回日本肥満症治療学会学術集会
  • Place of Presentation: ピアザ淡海(滋賀県大津市)
  • Year and Date: 2014-07-04
• [Presentation] 脂質異常症と認知症 (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2014-06-13
• [Presentation] 高齢者における糖尿病治療戦略 (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2014-06-12
• [Presentation] 糖尿病の脂質管理 (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2014-05-24
• [Presentation] 指定発言：疾患別項目セットの策定と方向性- 脂質異常症の立場から (2014)
  • Author(s): 横手幸太郎
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2014-05-23
• [Presentation] Therapeutic Strategy for prevention of atherosclerosis in Diabetes. (2014)
  • Author(s): Yokote, K
  • Organizer: The 18th International Vascular Biology Meeting Luncheon Seminor
  • Place of Presentation: みやこめっせ(京都府京都市)
  • Year and Date: 2014-04-17