Pathological elucidation of age-related diseases by integrative analyses of senescence genes
Project/Area Number |
26293165
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
|
Research Institution | Chiba University |
Principal Investigator |
Yokote Koutaro 千葉大学, 医学(系)研究科(研究院), 教授 (20312944)
|
Co-Investigator(Kenkyū-buntansha) |
清水 孝彦 千葉大学, 医学(系)研究科(研究院), 准教授 (40301791)
竹本 稔 千葉大学, 医学(系)研究科(研究院), 准教授 (60447307)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 老年医学 / 老化 / 遺伝子 / 早老症 / ウェルナー |
Outline of Final Research Achievements |
Werner syndrome (WS) is progeroid syndrome and is caused by the recessive mutation of WRN gene. WS patients exhibit accelerated telomere shortening. However, Wrntm1Lgu, TercG4/G4 double-null mice have failed to deteriorate pathologies of Wrntm1Lgu single-null mice. In this study, to reconfirm pathological significance of telomere in a WS model, we generated Wrntm1Lgu, Terttm1Fish double-null mice and intercrossed those mice until G4 generation (TertG4/G4) to induce telomere shortening. Although both TertG4/G4 or Wrn-/-, TertG4/G4 double null mice showed significant shortening of telomere length in various organs, Wrn-/-, TertG4/G4 mice were grown without apparent abnormality in muscle, liver as well as bone. However, Wrn-/-, TertG4/G4 mice only deteriorated fat atrophy in skin and testis degeneration, but not epidermis and dermis atrophies. These results suggested that the telomere shortening by Tert deficiency is in part attributable to premature aging pathologies in WS models.
|
Report
(4 results)
Research Products
(90 results)
-
-
-
-
-
[Journal Article] Balfour Sartor, John P Iredale, Jack Satsangi. MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.2017
Author(s)
Gwo-Tzer Ho, Rhona E Aird, Bo Liu, Nicholas A Kennedy, David A Dorward, Colin L Noble, Takahiko Shimizu, Nicholas M Morton, Adriano G Rossi, R. Balfour Sartor, John P Iredale, Jack Satsangi.
-
Journal Title
Mucosal Immunology
Volume: -
Pages: 印刷中
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice.2017
Author(s)
Oyama, J.*, Shirakihara, A., Nishikido, T., Maeda, T., Komoda, H., Shimizu, T., Makino, N., Node, K.
-
Journal Title
J Cardiol.
Volume: 69
Pages: 417-427
DOI
Related Report
Open Access
-
[Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.2017
Author(s)
Tuerdi, A. Kinoshita, M., Kamogashira, T., Fujimoto, C. Iwasaki, S., Shimizu, T., Yamasoba, T.
-
Journal Title
Neurosci. Lett.
Volume: 642
Pages: 123-128
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.2016
Author(s)
Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
-
Journal Title
J Clin Endocrinol Metab
Volume: 101
Pages: 841-846
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation.2016
Author(s)
Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Shimizu, T., Jae Youl Cho, Dae Bang Seo*, Song Seok Shin*.
-
Journal Title
J. Ginseng Res.
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid b42 and its application toward the Alzheimer's disease diagnosis.2016
Author(s)
Murakami, K., Tokuda, M., Suzuki, T., Irie, Y., Hanaki, M., Izuo, N., Monobe, Y., Akagi, K., Ishii, R., Tatebe, H., Tokuda, T., Maeda, M., Kume, T., Shimizu, T., Irie, K.*
-
Journal Title
Sci. Rep.
Volume: 6
Pages: 29038
DOI
Related Report
-
[Journal Article] Cushing syndrome due to ACTH-secreting pheochromocytoma aggravated by a glucocorticoid-driven positive-feedback loop.2015
Author(s)
Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
-
Journal Title
J Clin Endocrinol Metab
Volume: 101(3)
Pages: 841-846
DOI
Related Report
Open Access
-
-
[Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.2015
Author(s)
Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
-
Journal Title
Sci Rep
Volume: -
Pages: 5:17565
DOI
Related Report
Open Access
-
[Journal Article] Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.2015
Author(s)
Sakamoto K, Kuno K, Takemoto M, He P, Ishikawa T, Onishi S, Ishibashi R, Okabe E, Shoji M, Hattori A, Yamaga M, Kobayashi K, Kawamura H, Tokuyama H, Maezawa Y, Yokote K.
-
Journal Title
Diabetes Res.
Volume: 2015
Pages: 727152
DOI
Related Report
Open Access
-
[Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns.2015
Author(s)
Matsumoto J, Hirano Y, Numata N, Matzuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
-
Journal Title
J Eat Disord
Volume: -
Pages: 3:14
DOI
Related Report
Open Access
-
[Journal Article] Germline deletion of ARMC5 in familial primary macronodular adrenal hyperplasia. Endocr Pract.2015
Author(s)
Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T.
-
Journal Title
Endocr Pract
Volume: 21(10)
Pages: 1152-1160
DOI
Related Report
Open Access
-
-
[Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.2015
Author(s)
Kobayashi K, Nojiri H, Saita Y, Morikawa D, Ozawa Y, Watanabe K, Koike M, Asou Y, Shirasawa T, Yokote K, Kaneko K, Shimizu T.
-
Journal Title
Sci Rep
Volume: 16
Pages: 5:9148
DOI
Related Report
Open Access
-
[Journal Article] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.2015
Author(s)
Koike M, Nojiri H, Ozawa Y, Watanabe K, Muramatsu Y, Kaneko H, Morikawa D, Kobayashi K, Saita Y, Sasho T, Shirasawa T, Yokote K, Kaneko K, Shimizu T.
-
Journal Title
Sci Rep
Volume: 25
Pages: 5:11722
DOI
Related Report
Open Access
-
-
-
-
-
[Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone (Study for an Ultimate Combination Therapy to Control Diabetes with Sitagliptin-1): A multicenter, randomized, open-label, non-inferiority trial.2015
Author(s)
Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K.
-
Journal Title
J Diabetes Investig
Volume: 6(2)
Pages: 182-191
DOI
Related Report
Open Access
-
[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
Author(s)
Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
-
Journal Title
Leuk Lymphoma
Volume: 56(10)
Pages: 1-4
DOI
Related Report
Open Access
-
-
-
-
-
-
[Journal Article] Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.2015
Author(s)
Sakamoto K, Kuno K, Takemoto M, He P, Ishikawa T, Onishi S, Ishibashi R, Okabe E, Shoji M, Hattori A, Yamaga M, Kobayashi K, Kawamura H, Tokuyama H, Maezawa Y, Yokote K
-
Journal Title
J Diabetes Res
Volume: 印刷中
Pages: 印刷中
DOI
Related Report
-
-
[Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with T2DM inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial.2014
Author(s)
Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K.
-
Journal Title
Diabetes Obes Metab
Volume: 16
Pages: 761-765
DOI
Related Report
-
[Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity.2014
Author(s)
Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Johan A, Frank J G, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
-
Journal Title
Scientific Reports
Volume: -
Pages: 1-10
DOI
Related Report
-
-
-
-
[Presentation] 高齢者糖尿病の治療目標2017
Author(s)
横手幸太郎
Organizer
第54回日本糖尿病学会関東甲信越地方会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2017-01-22
Related Report
-
-
[Presentation] 肥満症の治療2016
Author(s)
横手幸太郎
Organizer
第37回日本肥満学会
Place of Presentation
東京ファッションタウン(東京都江東区)
Year and Date
2016-10-07
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 肥満症に対する内科的治療2016
Author(s)
横手幸太郎
Organizer
第50回日本成人病(生活習慣病)学会学術集会
Place of Presentation
都市センターホテル(東京都千代田区)
Year and Date
2016-01-16
Related Report
-
-
[Presentation] Novel approach to residual risk, K-877, a potent and selective PPAR-α Modulator(SPPARMα), added-on to Pitavastatin in Japanese patients with dyslipidemia.2015
Author(s)
Yokote K, Ishibashi S, Yamashita S, Arai H, Araki E, Suganami H, Kodama T.
Organizer
American Heart Association Scientific Session 2015
Place of Presentation
Orange County Convention Center(Orlando, USA.)
Year and Date
2015-11-09
Related Report
Int'l Joint Research
-
-
-
-
-
[Presentation] 肥満症の治療と管理2015
Author(s)
横手幸太郎、徳山宏丈
Organizer
第36回日本肥満学会
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2015-10-02
Related Report
-
-
-
-
-
[Presentation] 肥満症の総合的治療戦略2015
Author(s)
横手幸太郎
Organizer
第33回日本肥満症治療学会学術集会
Place of Presentation
幕張国際研修センター(千葉県千葉市)
Year and Date
2015-06-26
Related Report
-
-
-
[Presentation] 脂質異常症治療の展望2015
Author(s)
横手幸太郎
Organizer
第58回日本糖尿病学会年次学術集会
Place of Presentation
海峡メッセ下関(山口県下関市)
Year and Date
2015-05-22
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 脂質異常症と認知症2014
Author(s)
横手幸太郎
Organizer
第56回日本老年医学会学術集会
Place of Presentation
福岡国際会議場(福岡県福岡市)
Year and Date
2014-06-13
Related Report
-
-
[Presentation] 糖尿病の脂質管理2014
Author(s)
横手幸太郎
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2014-05-24
Related Report
-
-