Elucidation of Prognostic Markers and their Molecular Mechanism for Thyroid Cancer

• Project/Area Number: 26293222
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Nagasaki University
• Principal Investigator: YAMASHITA Shunichi 長崎大学, 原爆後障害医療研究所, 教授 (30200679)
• Co-Investigator(Kenkyū-buntansha): 中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683) ; 光武 範吏 長崎大学, 原爆後障害医療研究所, 准教授 (50404215) ; サエンコ ウラジミール 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 内分泌学 / 甲状腺がん / 遺伝子診断 / 発がん機構 / 遺伝子異常 / 発がんメカニズム

Outline of Final Research Achievements

We have demonstrated that the coexistence of the BRAF and the TERT promoter mutation is strongly associated with recurrence of thyroid cancers. This may be very useful for clinical management of thyroid cancer patients. However, the TERT promoter mutation is strongly correlated with higher age, implying that this marker is unfortunately not useful for young patients. The FOXE1 overexpression is observed in thyroid cancer tissues but may not have a strong influence on cancer development. We have also identified that the intracellular signaling cascade, PDGFbeta/JAK/STAT/NF-kappaB, plays an important role in the cancer stem properties in thyroid cancer stem cells. These results enable us to provide a molecular basis for a novel molecular-targeted therapy.

Research Products

• [Journal Article] Lessons from Fukushima: Latest Findings of Thyroid Cancer After the Fukushima Nuclear Power Plant Accident. (2018)
  • Author(s): Yamashita S, Suzuki S, Suzuki S, Shimura H, Saenko V.
  • Journal Title: Thyroid Volume: 28 Issue: 1 Pages: 11-22
  • DOI: 10.1089/thy.2017.0283
  • NAID: 120006987977
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters (2018)
  • Author(s): Todorovic Lidija、Stanojevic Boban、Mandusic Vesna、Petrovic Nina、Zivaljevic Vladan、Paunovic Ivan、Diklic Aleksandar、Saenko Vladimir、Yamashita Shunichi
  • Journal Title: Medical Oncology Volume: 35 Issue: 2 Pages: 17-17
  • DOI: 10.1007/s12032-017-1066-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] What Is the “Screening Effect” Six Years After the Fukushima Nuclear Power Plant Accident? (2017)
  • Author(s): Yamashita Shunichi、Saenko Vladimir A.
  • Journal Title: Thyroid Volume: 27 Issue: 5 Pages: 595-596
  • DOI: 10.1089/thy.2017.0154
  • Peer Reviewed
• [Journal Article] Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima. (2017)
  • Author(s): Iyama K, Matsuse M, Mitsutake N, Rogounovitch T, Saenko V, Suzuki K, Ashizawa M, Ookouchi C, Suzuki S, Mizunuma H, Fukushima T, Suzuki S, Yamashita S.
  • Journal Title: Thyroid Volume: 印刷中 Issue: 6 Pages: 811-818
  • DOI: 10.1089/thy.2016.0673
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer. (2017)
  • Author(s): Khvostunov IK, Saenko VA, Krylov V, Rodichev A, Yamashita S.
  • Journal Title: Radiat Environ Biophys Volume: 56 Issue: 3 Pages: 213-226
  • DOI: 10.1007/s00411-017-0696-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] TERT Promoter Mutations Were Not Found in Papillary Thyroid Microcarcinomas That Showed Disease Progression on Active Surveillance. (2017)
  • Author(s): Yabuta T, Matsuse M, Hirokawa M, Yamashita S, Mitsutake N, Miyauchi A.
  • Journal Title: Thyroid Volume: 27(9) Issue: 9 Pages: 1206-1207
  • DOI: 10.1089/thy.2016.0645
  • Peer Reviewed
• [Journal Article] Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine (2017)
  • Author(s): Bogdanova TI, Saenko VA, Hirokawa M, Ito M, Zurnadzhy LY, Hayashi T, Rogounovitch TI, Miyauchi A, Tronko MD, Yamashita S.
  • Journal Title: Endocrine Journal Volume: 64 Issue: 10 Pages: 977-993
  • DOI: 10.1507/endocrj.EJ17-0134
  • NAID: 130006186081
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Findings of Thyroid Ultrasound Examination Within 3 Years After the Fukushima Nuclear Power Plant Accident: The Fukushima Health Management Survey (2017)
  • Author(s): Shimura Hiroki、Sobue Tomotaka、Takahashi Hideto、Yasumura Seiji、Ohira Tetsuya、Ohtsuru Akira、Midorikawa Sanae、Suzuki Satoru、Fukushima Toshihiko、Suzuki Shinichi、Yamashita Shunichi、Ohto Hitoshi、Thyroid Examination Unit of the Radiation Medical Center for the Fukushima Health Management Survey Group
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 103 Issue: 3 Pages: 861-869
  • DOI: 10.1210/jc.2017-01603
  • Peer Reviewed
• [Journal Article] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma (2017)
  • Author(s): Nikitski A, Rogounovitch T, Bychkov A, Takahashi M, Yoshiura KI, Mitsutake N, Kawaguchi T, Matsuse M, Drozd VM, Demidchik YE, Nishihara E, Hirokawa M, Miyauchi A, Rubanovitch AV, Matsuda F, Yamashita S, Saenko VA
  • Journal Title: Thyroid Volume: 27(2) Pages: 224-235
  • NAID: 120006987557
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors (2017)
  • Author(s): Matsuse M, Yabuta T, Saenko V, Hirokawa M, Nishihara E, Suzuki K, Yamashita S, Miyauchi A, Mitsutake N
  • Journal Title: Sci Rep Volume: 7 Pages: 41752-41752
  • NAID: 120006987562
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET in Thyroid Cancers of Young Patients in Fukushima (2017)
  • Author(s): Iyama K, Matsuse M, Mitutake N, Rogounovitch T, Saenko VA, Suzuki K, Ashizawa M, Ookouchi C, Suzuki S, Mizunuma H, Fukushima T, Suzuki S, Yamashita S
  • Journal Title: Thyroid Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Targeted Foxe1 overexpression in mouse thyroid causes the development of multinodular goiter but does not promote carcinogenesis (2016)
  • Author(s): Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
  • Journal Title: Endocrinology Volume: 157(5) Pages: 2182-2195
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ionizing radiation-induced cell death is partly caused by increase of mitochondrial reactive oxygen species in normal human fibroblast cells (2015)
  • Author(s): Kobashigawa S, Kashino G, Suzuki K, Yamashita S, Mori H
  • Journal Title: Radiat Res Volume: 183(4) Pages: 455-464
  • Peer Reviewed / Open Access
• [Journal Article] Health effects of radiation and other health problems in the aftermath of nuclear accidents, with an emphasis on Fukushima. (2015)
  • Author(s): Hasegawa A, Tanigawa K, Ohtsuru A, Yabe H, Maeda M, Shigemura J, Ohira T, Tominaga T, Akashi M, Hirohashi N, Ishikawa T, Kamiya K, Shibuya K, Yamashita S, Chhem R
  • Journal Title: Lancet Volume: 386(9992) Pages: 479-488
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nuclear disasters and health: lessons learned, challenges, and proposals. (2015)
  • Author(s): Ohtsuru A, Tanigawa K, Kumagai A, Niwa O, Takamura N, Midorikawa S, Nollet K, Yamashita S, Ohto H, Chhem RK, Clarke M
  • Journal Title: Lancet Volume: 386(9992) Pages: 489-497
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role? (2015)
  • Author(s): Drozd VM, Saenko VA, Brenner AV, Drozdovitch V, Pashkevich VI, Kudelsky AV, Demidchik YE, Branovan I, Shiglik N, Rogounovitch TI, Yamashita S, Biko J, Reiners C
  • Journal Title: PLoS one Volume: 10(9)
  • NAID: 120006986839
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Perspective: Health-Risk Implications of the Fukushima Nuclear Power Plant Acciden (2015)
  • Author(s): Suzuki K, Yamashita S
  • Journal Title: Fukushima Nuclear Accident: global implications, long-term health effects, and ecological consequences, Nova Science Publishers, New York Volume: Sutoh S, eds
  • Open Access
• [Journal Article] BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl. (2015)
  • Author(s): Mitsutake N, Fukushima T, Matsuse M, Rogounovitch T, Saenko V, Uchino S, Ito M, Suzuki K, Suzuki S, Yamashita S
  • Journal Title: Sci Rep Volume: 5 Pages: 16976-16976
  • NAID: 120006986823
  • Peer Reviewed / Open Access
• [Journal Article] Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection (2015)
  • Author(s): Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S
  • Journal Title: Ann ICRP Volume: 4(3-4) Pages: 7-357
  • Open Access / Int'l Joint Research
• [Journal Article] Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma (2015)
  • Author(s): Stanojevic B, Nakashima M, et al
  • Journal Title: PLoS One Volume: 9 Issue: 12 Pages: e114511-e114511
  • DOI: 10.1371/journal.pone.0114511
  • NAID: 120006986319
  • Peer Reviewed / Open Access
• [Journal Article] Radiation signatures in childhood thyroid cancers after the Chernobyl accident: possible roles of radiation in carcinogenesis (2015)
  • Author(s): Suzuki K, Mitsutake N, Saenko V, Yamashita S
  • Journal Title: Cancer Sci Volume: 106 Issue: 2 Pages: 127-33
  • DOI: 10.1111/cas.12583
  • NAID: 120006987087
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Unstable chromosome aberrations do not accumulate in normal fibroblast after fractionated x-irradiation. (2015)
  • Author(s): Ojima M, Ito M, Suzuki K, Kai M
  • Journal Title: PLoS One Volume: 10(2) Issue: 2 Pages: e0116645-e0116645
  • DOI: 10.1371/journal.pone.0116645
  • Peer Reviewed / Open Access
• [Journal Article] The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population. (2015)
  • Author(s): Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA.
  • Journal Title: Thyroid Volume: 25 Issue: 3 Pages: 333-340
  • DOI: 10.1089/thy.2014.0431
  • NAID: 120006987147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potentiation of osteoclastogenesis by adipogenic conversion of bone marrowderivedmesenchymal stem cells (2014)
  • Author(s): Mori K, Suzuki K, Hozumi A, Goto H, Tomita M, Koseki H, Yamashita S, Osaki M
  • Journal Title: Biomedical Research Volume: 35 Issue: 2 Pages: 153-159
  • DOI: 10.2220/biomedres.35.153
  • NAID: 130004470861
  • ISSN: 0388-6107, 1880-313X
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of multiple markers for cancer stem-like cells in human thyroid carcinoma cell lines (2014)
  • Author(s): Shimamura M, Nagayama Y, Matsuse M, Yamashita S, Mitsutake N
  • Journal Title: Endocrine Journal Volume: 61 Issue: 5 Pages: 481-490
  • DOI: 10.1507/endocrj.EJ13-0526
  • NAID: 130004443968
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation (2014)
  • Author(s): CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
  • Journal Title: PLoS One Volume: 9 Issue: 8 Pages: e104279-e104279
  • DOI: 10.1371/journal.pone.0104279
  • NAID: 120006986457
  • Peer Reviewed / Open Access
• [Presentation] Genetic Alterations in Thyroid Cancers Found by the Mass-screening in Fukushima (2018)
  • Author(s): Norisato Mitsutake, Michiko Matsuse, Vladimir Saenko, Shinichi Suzuki, Shunichi Yamashita
  • Organizer: The 2nd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research
• [Presentation] Apoptosis of primary thyroid follicular cells by co-culture of malignant thyroid carcinoma cell lines. (2018)
  • Author(s): Aidana Amrenova, Keiji Suzuki, Shunichi Yamashita
  • Organizer: The 2nd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research
• [Presentation] Immunohistochemical Analysis of BRAF Mutational Status in the Papillary Thyroid Carcinoma with Special Reference to Recurrent Tumors. (2018)
  • Author(s): Alexander Abrosimov, Tatiana Rogounovitch, Alexei Sidorin, Pavel Rumyantsev, Pavel Isaev, Kseniya Nizhegorodova, Anna Shinkarkina, Shunichi Yamashita, Vladimir Saenko
  • Organizer: The 2nd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research / Invited
• [Presentation] Papillary Thyroid Carcinoma Associated with Post-Chernobyl Exposure to Radiation: a Comparative Analysis of Clinical and Morphological Characteristics According to BRAF Mutational Status in Young Adults of Belarus. (2018)
  • Author(s): Mikhail Frydman, Tatiana Rogounovitch, Sviatlana Mankovskaya, Shunichi Yamashita, Vladimir Saenko
  • Organizer: The 2nd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research / Invited
• [Presentation] 福島の小児および思春期の甲状腺乳頭癌における新規融合癌遺伝子の同定 (2017)
  • Author(s): 井山慶大, 光武範吏, 松瀬美智子, タチアナ ログノビッチ, ウラジミール サエンコ, 鈴木啓司, 芦澤 舞, 大河内千代, 鈴木 聡, 水沼 廣, 福島俊彦, 鈴木眞一, 山下俊一
  • Organizer: 第90回日本内分泌学会学術総会
• [Presentation] 組織反応を基盤とした低線量率・低線量放射線影響の解析 (2017)
  • Author(s): 鈴木啓司, 光武範吏, 山下俊一
  • Organizer: 第2回 放射線災害・医科学研究拠点カンファランス
• [Presentation] 甲状腺がんの基礎と臨床；チェルノブイリと福島の経験から (2017)
  • Author(s): 山下俊一
  • Organizer: 第5回日本甲状腺病理学会総会・学術集会
  • Invited
• [Presentation] Nuclear Disaster and Thyroid Cancer (2017)
  • Author(s): Shunichi Yamashita
  • Organizer: The XII International scientific-practical conference “Ecology. Radiation. Health”
  • Int'l Joint Research / Invited
• [Presentation] Histopathological features of sporadic papillary thyroid carcinoma in children and adolescents of Japan and Ukraine (2017)
  • Author(s): Bogdanova Tetiana、サエンコ ウラジミール、廣川満良、伊藤正博、Zurnadzhy Liudmyla、ログノビッチ タチアナ、宮内 昭、Tronko Mykola、山下俊一
  • Organizer: 第60回日本甲状腺学会学術集会
• [Presentation] Is the common SNP rs966423 at chromosome 2q35 etiology-specific and confers risk for sporadic thyroid cancer only? (2017)
  • Author(s): ログノビッチ タチアナ、サエンコ ウラジミール、Leonava Tatsiana、Drozd Valentina、高橋めい子、川口喬久、光武範吏
  • Organizer: 第60回日本甲状腺学会学術集会
• [Presentation] 甲状腺癌幹細胞に重要なシグナル伝達経路の解析 (2017)
  • Author(s): 松瀬美智子、白岩 健、光武範吏、山下俊一
  • Organizer: 第60回日本甲状腺学会学術集会
• [Presentation] 原子力災害と健康リスク管理：チェルノブイリと福島の経験から学ぶ (2017)
  • Author(s): 山下 俊一
  • Organizer: 第32回中日工程技術検討会
  • Int'l Joint Research / Invited
• [Presentation] Genetic signatures of thyroid cancer according to radiation dose level (2016)
  • Author(s): Vladimir Saenko
  • Organizer: Joint symposium of KTA-KHNP “Thyroid cancer
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-12-02
  • Int'l Joint Research / Invited
• [Presentation] 甲状腺がん発症分子機構解明の為の特異的転写応答合成プロモーター活性を指標とした高感度細胞内シグナル活性経路検出アッセイ系の確率 (2016)
  • Author(s): サエンコ ウラジミール
  • Organizer: 第59回日本甲状腺学会学術集会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2016-11-03
• [Presentation] Studies of molecular features of radiation-induced and sporadic papillary thyroid carcinomas (2016)
  • Author(s): タチアナ ログノビッチ
  • Organizer: 第59回日本甲状腺学会学術集
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2016-11-03
• [Presentation] 定量RT-PCR法を用いた融合遺伝子スクリーニングにより同定した甲状腺癌新規融合遺伝子の機能解析 (2016)
  • Author(s): 松瀬美智子, 井山慶大, Vladimir Saenko, 光武範吏, 山下俊一
  • Organizer: 第59回日本甲状腺学会学術集会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2016-11-03
• [Presentation] 甲状腺乳頭癌における分子マーカーによるリスク分類 (2016)
  • Author(s): 光武範吏, 松瀬美智子, 薮田智範, Vladimir Saenko, 西原永潤, 廣川満良, 宮内 昭, 山下俊一
  • Organizer: 第49回日本甲状腺外科学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（山梨県甲府市）
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 原発事故と健康影響：甲状腺がんリスクの基礎知識について (2016)
  • Author(s): 山下俊一
  • Organizer: 第34回内分泌代謝学サマーセミナー
  • Place of Presentation: 対馬グランドホテル（長崎県対馬市）
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] 甲状腺乳頭癌における悪性度・予後を規定する遺伝子変異 (2016)
  • Author(s): 光武範吏, 松瀬美智子, 薮田智範, Vladimir Saenko, 西原永潤, 廣川満良, 宮内 昭, 山下俊一
  • Organizer: 第28回日本内分泌外科学会
  • Place of Presentation: ロイヤルホールヨコハマ（神奈川県横浜市）
  • Year and Date: 2016-05-26
  • Invited
• [Presentation] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma (2016)
  • Author(s): ニキツキー アリャクサンドル, サエンコ ウラジミル, ログノビッチ タチアナ,ビチコブ アンドレイ, 高橋めい子, 吉浦孝一郎, 光武範吏, 川口喬久, 松瀬美智子, ドロズド ワレンチナ, デミドチック ユリ, 西原永潤, 廣川満良, 宮内 昭, ルバノビッチ アレクサンドル, 松田文彦, 山下俊一
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-21
• [Presentation] Novel RET/PTC rearrangement identified by RNA-NGS in a sporadic pediatric PTC (2016)
  • Author(s): ログノビッチ タチアナ, サエンコ ウラジミール, マンコフスカヤ スベトナラ,フリドマン ミハイル, デミドチック ユリ, 山下俊一
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-21
• [Presentation] 甲状腺乳頭癌における遺伝子変異と悪性度・予後との関連 (2016)
  • Author(s): 光武範吏, 松瀬美智子, 薮田智範, Saenko Vladimir, 西原永潤, 廣川満良, 宮内 昭, 山下俊一
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-21
• [Presentation] Radiation Health Risk Management after the Fukushima Daiichi Nuclear Power Plan Accident (2015)
  • Author(s): Shunichi Yamashita
  • Organizer: World Engineering Conference and Convention(WECC)2015
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2015-11-29
  • Int'l Joint Research / Invited
• [Presentation] Accumulation of DNA damage response in tissues exposed to low-dose/low-dose-rate gamma-rays (2015)
  • Author(s): Keiji Suzuki
  • Organizer: One Health Conference in Nagasaki
  • Place of Presentation: 長崎大学（長崎県長崎市）
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] 放射線と甲状腺ー震災から4年半を経過してー (2015)
  • Author(s): 山下俊一
  • Organizer: 第58回日本甲状腺学会学術集会
  • Place of Presentation: 福島県文化センター（福島県福島市）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] Establishment of a synthetic promoter-based system for sensing oncogenic alteration in human live thyroid cells at a single-cell level (2015)
  • Author(s): Vladimir Saenko
  • Organizer: 第58回日本甲状腺学会学術集会
  • Place of Presentation: 福島県文化センター（福島県福島市）
  • Year and Date: 2015-11-05
• [Presentation] Functional characterization of a new Ret/PTC rearrangement identified by RNA-NGS in a sporadic pediatric PTC (2015)
  • Author(s): T.Rogounovitch, V.Saenko, S.Mankouskaya, M.Fridman, Yu.Demidchik, S.Yamashita
  • Organizer: 第58回日本甲状腺学会学術集会
  • Place of Presentation: 福島県文化センター（福島県福島市）
  • Year and Date: 2015-11-05
• [Presentation] BRAF及びTERTプロモーター変異と甲状腺乳頭癌の悪性度との関連 (2015)
  • Author(s): 松瀬美智子、薮田智範、江本大紀、Vladimir Saenko、西原永潤、廣川満良、宮内昭、光武範吏、山下俊一
  • Organizer: 第58回日本甲状腺学会学術集会
  • Place of Presentation: 福島県文化センター（福島県福島市）
  • Year and Date: 2015-11-05
• [Presentation] 小児甲状腺乳頭癌におけるBRAF異常の検討 (2015)
  • Author(s): 福島俊彦、光武範吏、中野恵一、中村泉、鈴木聡、斎藤勝治、鈴木悟、山下俊一、鈴木眞一
  • Organizer: 第58回日本甲状腺学会学術集会
  • Place of Presentation: 福島県文化センター（福島県福島市）
  • Year and Date: 2015-11-05
• [Presentation] Analysis of the initial DNA damage and tissue reaction related to radiation-induced cancer (2015)
  • Author(s): 鈴木啓司
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Radiation and Thyroid Cancer；lessons learned from Hiroshima, Nagasaki and Chernobyl to Fukushima (2015)
  • Author(s): Shunichi Yamashita
  • Organizer: 国際フォーラム(IAAO2015)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2015-07-24
  • Int'l Joint Research / Invited
• [Presentation] 小児甲状腺結節・がんの治療ガイドライン（アメリカ甲状腺学会2015最新版）の概要と課題 (2015)
  • Author(s): 山下俊一
  • Organizer: 第27回日本内分泌外科学会総会
  • Place of Presentation: コラッセ福島（福島県福島市）
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] 小児・若年者甲状腺癌に見られる遺伝子変異 (2015)
  • Author(s): 光武範吏、松瀬美智子、Tatiana Rogounovitch、Vladimir Saenko、福島俊彦、鈴木眞一、山下俊一
  • Organizer: 第27会日本内分泌外科学会総会
  • Place of Presentation: コラッセ福島（福島県福島市）
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] Foxe1 Overexpression and Radiation Effects on Mouse Thyroid (2015)
  • Author(s): Akyaksandr Nikitski, Norisato Misutake, Keiji Suzuki, Vlacimir Saenko, Tatiana Rogounovitch, Shunichi Yamashita
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] DNA damage response and tissue reaction in mouse tissue/organs exposed low-dose/low-dose-rate radiation (2015)
  • Author(s): Keiji Suzuki
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research / Invited
• [Presentation] Gene rearrangements in radiation-induced thyroid cancer (2015)
  • Author(s): Sank Vladimir
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: Kyoto International Conference Center, kyoto
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Storage of Biosamples from Atomic Bomb Survivors at Nagasaki University (2015)
  • Author(s): Masahiro Nakashima, Shiro Miura, Katsuya Matsuda, Mutsumi Matsuyama, Nozomi Ueki, Masahiro Ito, and Shunichi Yamashita
  • Organizer: The 1st International Workshop on Sample/Tissue Archiving of Radiobiology (STAR2015)
  • Place of Presentation: Shirankaikan Annex. Kyoto
  • Year and Date: 2015-05-24
  • Int'l Joint Research / Invited
• [Presentation] High risk of hypothyroidism in the survivors of childhood medulloblastoma (2015)
  • Author(s): Konoplya Natalya, Karas Olga, Saenko Vladimir, Rogounovitch Tatiana, Demidchik Yuri, Aleynykova Olga, Yamashita Shunichi
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京（東京都千代田区）
  • Year and Date: 2015-04-23
• [Presentation] Novel Ret/PTC rearrangement identified by RNA-NGS in a sporadic pediatric PTC (2015)
  • Author(s): T.Rogounovitch, V.Saenko, S.Mankouskaya, M.Fridman, Yu.Demidchik, S.Yamashita
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京（東京都千代田区）
  • Year and Date: 2015-04-23
• [Presentation] 放射線被ばくと甲状腺がんリスク (2015)
  • Author(s): 山下俊一
  • Organizer: 第29回日本医学会総会2015関西
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2015-04-10
  • Invited
• [Presentation] 三次元培養法を用いた新たな甲状腺初代培養法の開発 (2014)
  • Author(s): 松瀬美智子、鈴木啓司、山之内孝彰、光武範吏、山下俊一
  • Organizer: 第57回日本甲状腺学会学術集会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
  • Year and Date: 2014-11-14
• [Presentation] Effect of targeted overexpression of Foxe1 on a mouse thyroid (2014)
  • Author(s): A. Nikitski, N. Mitsutake, V. Saenko, T. Rogounovitch, S. Yamashita
  • Organizer: 第57回日本甲状腺学会学術集会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
  • Year and Date: 2014-11-14
• [Presentation] Novel RET/PTC rearrangement identified by RNA-NGS in a sporadic pediatric PTC from Belarus (2014)
  • Author(s): T. Rogounovitch, V. Saenko, S. Mankouskaya. M. Fridman, Yu. Demidchik, Y. Yamashita
  • Organizer: 第57回日本甲状腺学会学術集会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
  • Year and Date: 2014-11-14
• [Presentation] 放射線被ばくと甲状腺がん (2014)
  • Author(s): 山下俊一
  • Organizer: 「低線量・低線量率放射線による発がんを考える」シンポジウム放射線影響学会第57回大会
  • Place of Presentation: かごしま県民交流センター（鹿児島市山下町）
  • Year and Date: 2014-10-01
  • Invited
• [Presentation] 放射線発がんにつながる初期組織反応 (2014)
  • Author(s): 鈴木啓司、山内一己、今岡達彦、山下俊一
  • Organizer: 「低線量・低線量率放射線による発がんを考える」シンポジウム 放射線影響学会第57回大会
  • Place of Presentation: かごしま県民交流センター（鹿児島市山下町）
  • Year and Date: 2014-10-01
• [Presentation] Genetic alterations in thyroid cancer and their clinical implications (2014)
  • Author(s): Norisato Mitsutake
  • Organizer: Asia Oceania Thyroid Association Congress
  • Place of Presentation: Kochi（インド）
  • Year and Date: 2014-09-27
• [Presentation] DNA damage and tissue reaction in tissues/organs exposed to low-dose and low-dose-rate radiation in mice (2014)
  • Author(s): 鈴木啓司
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜市西区）
  • Year and Date: 2014-08-29
• [Presentation] 低線量率・低線量放射線被ばくによる組織DNA損傷の誘発と排除 (2014)
  • Author(s): 鈴木啓司、山下俊一
  • Organizer: 第55回原子爆弾後障害研究会
  • Place of Presentation: 長崎大学良順会館専斎ホール（長崎市坂本）
  • Year and Date: 2014-06-01
• [Presentation] 三次元培養法を用いた新たな甲状腺初代培養法の開発 (2014)
  • Author(s): 松瀬美智子、鈴木啓司、光武範吏、山下俊一
  • Organizer: 第10回広島大学・長崎大学連携研究事業カンファランス
  • Place of Presentation: 長崎大学良順会館専斎ホール（長崎市坂本）
  • Year and Date: 2014-05-31
• [Presentation] Association of Polymorphic variants in the FOXE1 locus with papillary thyroid carcinoma in the Japanese and Belarussian populations (2014)
  • Author(s): Vladimir Saenko, Tatiana Rogounovitch, Alyaksandr Nikitski, Norisato Mitsutake, Michiko Matsuse, Meiko Takahashi, Akira Miyauchi, Fumihiko Matsuda, Shunichi Yamashita
  • Organizer: 第10回広島大学・長崎大学連携研究事業カンファランス
  • Place of Presentation: 長崎大学良順会館専斎ホール（長崎市坂本）
  • Year and Date: 2014-05-31
• [Presentation] Accident at the Fukushima Daiichi NPP and thyroid cancer problem (2014)
  • Author(s): Vladimir Saenko
  • Organizer: XIV International Bioschool "Current topics in Radiation Biology"
  • Place of Presentation: オブニンスク医学放射線研究所（ロシア）
  • Year and Date: 2014-05-26 – 2014-05-30
  • Invited
• [Presentation] Association of polymorphism in the FOXE1 gene locus with papillary thyroid carcinoma in Japanese patients (2014)
  • Author(s): V.Saenko, T.Rogounovitch, A.Bychkov, N.Mitsutake, M.Matsuse, E.Nishihara, M.Hirokawa, A.Nikitsky, S. Minami, K.Yamanouchi, K.Yoshiura, A.Miyauchi, S.Yamashita
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡国際会議場（福岡市博多区）
  • Year and Date: 2014-04-25
• [Book] Fukushima nuclear accident: global implications, long-term health effects, and ecological consequences (2015)
  • Author(s): Suzuki K, Yamashita S
  • Total Pages: 259
  • Publisher: Nova Science Publishers
• [Remarks] 長崎大学原爆後障害医療研究所放射線リスク制御部門放射線災害医療学研究分野
  • URL: http://www-sdc.med.nagasaki-u.ac.jp/drms/index.html
• [Remarks] 長崎大学 原研医療ホームページ
  • URL: http://www-sdc.med.nagasaki-u.ac.jp/drms/
• [Remarks] 長崎大学原研医療ホームページ
  • URL: http://www-sdc.med.nagasaki-u.ac.jp/drms/member.html
• [Remarks] 長崎大学 原研医療ホームページ
  • URL: http://www.med.nagasaki-u.ac.jp/adi-pphy/index.html