A prospective study in order to identify inflammatory attack triggers in autoinflammatory diseases
Project/Area Number |
26293232
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Ehime University |
Principal Investigator |
Masumoto Junya 愛媛大学, プロテオサイエンスセンター, 教授 (20334914)
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Co-Investigator(Kenkyū-buntansha) |
伊藤 有紀 愛媛大学, プロテオサイエンスセンター, 助教 (10608334)
澤崎 達也 愛媛大学, プロテオサイエンスセンター, 教授 (50314969)
上松 一永 信州大学, 医学部, 准教授 (60262721)
右田 清志 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 病因解析研究部長 (60264214)
大澤 春彦 愛媛大学, 医学(系)研究科(研究院), 教授 (90294800)
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Research Collaborator |
Kaneko Naoe 愛媛大学, 大学院医学系研究科, 技術員
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|
Keywords | 自己炎症疾患 / インフラマソーム / 無細胞蛋白質合成システム / 家族性地中海熱 / クリオピリン関連周期熱症候群 |
Outline of Final Research Achievements |
Autoinflammatory disease is refractory inflammatory diseases characterized by recurrence of periodic fever. Several causative gene products reported be component of inflammasome, an IL-1β processing platform. We developed reconstituted inflammasome in a cell-free system to identify inflammatory attack triggers on autoinflamatory disease and identified several candidates as inflammatory attack trigger.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system.2017
Author(s)
Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Koga T, Kawakami A, Yachie A, Yoshiura K, Morikawa S, Kurata M, Masumoto J.
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Journal Title
European Journal of Inflammation
Volume: 印刷中
Issue: 2
Pages: 85-97
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis.2016
Author(s)
Iwasaki T, Kaneko N, Ito Y, Takeda H, Sawasaki T, Heike T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.
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Journal Title
The Scientific World Journal
Volume: -
Pages: 2597376-2597376
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever.2016
Author(s)
Koga T, Migita K, Sato S, Umeda M, Nonaka F, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura K, Eguchi K, Kawakami A.
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Journal Title
Medicine (Baltimore)
Volume: 95
Issue: 16
Pages: e3449-e3449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reconstituted AIM2 inflammasome in cell-free system2015
Author(s)
Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J
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Journal Title
J Immunol Methods
Volume: 426
Pages: 76-81
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes.2015
Author(s)
Mokuda S, Miyazaki T, Ito Y, Yamasaki S, Inoue H, Guo Y, Kong WS, Kanno M, Takasugi K, Sugiyama E, Masumoto J.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 9795-9795
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dysregulated mature IL-1β production in familial Mediterranean fever.2015
Author(s)
Migita K, Izumi Y, Fujikawa K, Agematsu K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M, Kawakami A, Eguchi K.
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Journal Title
Rheumatology (Oxford)
Volume: 54
Issue: 4
Pages: 660-665
DOI
Related Report
Peer Reviewed
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[Journal Article] The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocyte2015
Author(s)
Mokuda S, Miyazaki T, Ito Y, Yamasaki S, Inoue H, Guo Y, Kong W, Kanno M, Takasugi K, Sugiyama E, Masumoto J
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Journal Title
Scientific Reports
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations.2014
Author(s)
Sugiyama R, Agematsu K, Migita K, Nakayama J, Mokuda S, Ogura F, Haraikawa K, Okumura C, Suehiro S, Morikawa S, Ito Y, Masumoto J
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Journal Title
Mol Biol Rep
Volume: 41
Issue: 1
Pages: 545-553
DOI
Related Report
Peer Reviewed
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[Journal Article] Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients.2014
Author(s)
Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D, Uehara R, Nakamura Y, Jiuchi Y, Masumoto J, Furukawa H, Ida H, Terai C, Nakashima Y, Kawakami A, Nakamura T, Eguchi K, Yasunami M, Yachie A.
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Journal Title
Medicine (Baltimore)
Volume: 93
Issue: 3
Pages: 158-164
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum amyloid A induces NLRP-3-mediated IL-1β secretion in neutrophils.2014
Author(s)
Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Nakamura M, Nakamura T, Agematsu K, Masumoto J, Yasunami M, Kawakami A, Eguchi K.
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Journal Title
PLoS One
Volume: 9
Issue: 5
Pages: e96703-e96703
DOI
Related Report
Peer Reviewed / Open Access
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