| Project/Area Number |
26293268
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
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| Co-Investigator(Kenkyū-buntansha) |
東川 桂 北海道大学, アイソトープ総合センター, 助教 (10756878)
川井 恵一 金沢大学, 保健学系, 教授 (30204663)
浅田 祐士郎 宮崎大学, 医学部, 教授 (70202588)
鐙谷 武雄 北海道大学, 大学病院, 助教 (80270726)
七戸 秀夫 北海道大学, 大学病院, 准教授 (80374479)
山下 篤 宮崎大学, 医学部, 准教授 (90372797)
玉木 長良 北海道大学, 医学(系)研究科(研究院), 特任教授 (30171888)
西嶋 剣一 北海道大学, 大学病院, 薬剤師 (60364254)
志水 陽一 京都大学, 医学(系)研究科(研究院), 助教 (90634212)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 放射線 / 核医学診断 / 不安定プラーク / 低酸素イメージング / マクロファージ / 組織因子 / インテグリンαvβ３ / インテグリンαvβ3 |
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| Outline of Final Research Achievements |
The results obtained by our research are as follows.
(1) An automated synthesis method for 18F-RGD-K5 (an integrin αvβ3 imaging agent) has been successfully established. (2) Unlike 18F-FDG, 18F-FMISO (an hypoxia imaging agent) was found to accumulate in M2 macrophages present in hypoxic environment. (3) It was also confirmed that 2-nitroimidazole compounds selectively accumulated in the atherosclerotic regions of a rabbit model.
These results would contribute to establish diagnostic imaging of atherosclerosis.
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