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Molecular imaging of brain disease model mice by MRI and EPR imaging

Research Project

Project/Area Number 26293280
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

FUJII HIROTADA  札幌医科大学, 医療人育成センター, 教授 (70209013)

Co-Investigator(Renkei-kenkyūsha) SHIMOHAMA Syun  札幌医科大学, 医学部, 教授 (60235687)
SATO Shingo  山形大学, 理工学研究科, 教授 (30215793)
AKABA Hideo  大阪大学, 基礎工学研究科, 准教授 (00552077)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords脳疾患 / 分子イメージング / MRI / EPR / 酸化ストレス / レドックス / イメージング / 脳・神経疾患 / ROS / 磁気共鳴 / ストレス / 脳・神経 / 可視化
Outline of Final Research Achievements

Reactive oxygen species (ROS) and free radicals are continuously generated in brains. An excess of ROS has been reported to play an important role in neurodegenerative diseases. In the present stud, a new magnetic resonance-based imaging method using electron paramagnetic resonance and MRI was develop in order to visualize redox status in neurodegenerative disease model animals. Three animal models such as Alzheimer disease and epilepsy, was employed. Our new molecular imaging method clearly visualized a change in redox status of mouse brain, and these results can be used for medicine.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging2017

    • Author(s)
      Miho C. Emoto, Yuta Matsuoka, Ken-ichi Yamada, Hideo Sato-Akaba, Hirotada G. Fujii
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 485 Issue: 4 Pages: 802-806

    • DOI

      10.1016/j.bbrc.2017.02.134

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe.2015

    • Author(s)
      Emoto CM, Yamato M, Sato-Akaba H, Yamada K, Fujii GH.
    • Journal Title

      Neuroscience Letters

      Volume: 608 Pages: 40-44

    • DOI

      10.1016/j.neulet.2015.10.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamic changes in the distribution and time course of blood-brain barrier-permeative nitroxides in the mouse head with EPR imaging.2014

    • Author(s)
      Emoto MC, Sato-Akaba H, Hirata H, Fujii HG.
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 74 Pages: 222-228

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] In Vivo Brain Redox Status in Diethylmaleate-Treated Mice Using EPR Imaging2016

    • Author(s)
      3.Hirotada G Fujii, Miho C Emoto, Yuta Matsuoka, Ken-ichi Yamada
    • Organizer
      SfRBM's 23rd Annual Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Theranostics Imaging Probe for MRI and EPR Imaging2015

    • Author(s)
      Emoto, Miho Sato, Shingo Fujii, Hirotada G.
    • Organizer
      23th ISMRM
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2015-06-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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