| Project/Area Number |
26293283
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
KAWAMURA KAZUNORI 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, チームリーダー(定常) (50401766)
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| Co-Investigator(Kenkyū-buntansha) |
謝 琳 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 研究員(任常) (30623558)
藤永 雅之 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 主任研究員(定常) (70623726)
張 明栄 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 部長(定常) (80443076)
山崎 友照 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 研究員(任常) (80627563)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 核医学 / PET / 分子イメージング / 摂食 / 肥満 / イミダゾリン受容体 / グレリン受容体 / 分子ｲﾒｰｼﾞﾝｸﾞ / イミダゾリンI2受容体 / 放射線 / 肥満症 |
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| Outline of Final Research Achievements |
To treat obesity by drug therapy targeted a feeding center, several drugs have been developed. In this study, we developed the positron emission tomography (PET) probe for high affinity and selectivity imidazoline-I2 receptor (I2R), which is named ultrahigh specific activity [11C]BU99008. Also, we demonstrated to image and quantity a small change in a feeding center by obesity, and the relationship between I2R and obesity using [11C]BU99008-PET study in rats. Thus, we concluded that [11C]BU99008-PET study is helpful for the diagnostic tool or evaluation of drug therapy for obesity. Furthermore, we achieved to apply for clinical application using [11C]BU99008-PET study.
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