| Project/Area Number |
26293315
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Date Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (60252962)
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| Co-Investigator(Kenkyū-buntansha) |
陳 豊史 京都大学, 医学(系)研究科(研究院), 講師 (00452334)
小池 薫 京都大学, 医学(系)研究科(研究院), 教授 (10267164)
佐藤 寿彦 京都大学, 医学(系)研究科(研究院), 准教授 (40388822)
青山 晃博 京都大学, 医学(系)研究科(研究院), 助教 (60379047)
佐藤 雅昭 京都大学, 医学(系)研究科(研究院), 助教 (00623109)
山田 徹 京都大学, 医学(系)研究科(研究院), 助教 (90534347)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | lung transplantation / ex-vivo lung perfusion / inhalation therapy / circulatory death / surfactant / 心停止ドナー / 肺移植 / サーファクタント / Ex vivo lung perfusion / 肺傷害 |
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| Outline of Final Research Achievements |
Severe shortage of brain dead donor is unsolved problem in Japan. Lung transplantation from donation after circulatory arrest (DCD) may increase the donor pool. Ex-vivo lung perfusion (EVLP) is a potential modality to repair lung injury caused by warm ischemic change. Beagle lungs were harvested 150 minutes after circulatory arrest and perfused by EVLP for 4 hours and these lungs were implanted to the recipient animal. Inhalation with β2 adrenoreceptor agonist and surfactant during EVLP significantly improved lung function after transplantation. These results suggested that lung transplantation for DCD donor is possible.
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