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Development and practical application of a short-term replacement bone prosthesis to control infection

Research Project

Project/Area Number 26293339
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOkayama University

Principal Investigator

Tanaka Masato  岡山大学, 医歯(薬)学総合研究科, 准教授 (20379754)

Co-Investigator(Kenkyū-buntansha) 尾崎 敏文  岡山大学, 医歯(薬)学総合研究科, 教授 (40294459)
沖原 巧  岡山大学, 自然科学研究科, 講師 (70243491)
渡邉 典行  岡山大学, 大学病院, 医員 (80708107)
瀧川 朋亨  岡山大学, 大学病院, 助教 (80613166)
塩崎 泰之  岡山大学, 大学病院, 医員 (00596041)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywordsリン酸化プルラン / 骨髄炎 / 生体材料 / ドラッグデリバリー / 感染防御能 / 骨補填剤
Outline of Final Research Achievements

We investigated the availability of a new bone prosthetic material, which contains an antibacterial agent using phosphorylated-pullulan. Examination was done to measure the sustained release of the antibacterial agent from the bone prosthetic material. The new bone material had greater sustained release abilities compared to conventional bone material. Using an osteomyelitis mouse model, prepared by injecting S. aureus into the mouse bone marrow, we found a significant strong antimicrobial effect compared to conventional bone substitute material. These results suggest that phosphorylated-pullulan represents a drug delivery system for bone tissue, which is effective for preventing infections using an antibacterial agent.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Drug Delivery System of Antibi- otics by Phosphorylated Pullulan for Staphylococcus Osteomyelitis2017

    • Author(s)
      Noriyuki Watanabe, Aki Yoshida, Toshifumi Ozaki
    • Organizer
      ORS 2017 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多糖複合体を基材とした感染制御能と生体吸収性を有する抗菌薬含有セメントの開発2016

    • Author(s)
      渡邉典行,香川洋平,張偉,吉村将秀,吉田晶,田中雅人,吉田靖弘,松川昭博,尾崎敏文
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規生体材料リン酸化プルランによるインプラントコーティング技術の開発2016

    • Author(s)
      香川 洋平, 渡邉 典行, 張 偉, 吉村 将秀, 吉田 晶, 吉田 靖弘, 尾崎 敏文, 松川 昭博
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多糖複合体リン酸化プルランを用いた抗菌薬含有骨セメントの開発2015

    • Author(s)
      渡邉 典行
    • Organizer
      第35回整形外科バイオマテリアル研究会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多糖複合体リン酸化プルランを用いた抗菌薬含有骨セメントの開発2015

    • Author(s)
      渡邉 典行
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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