| Project/Area Number |
26293348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku University |
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Principal Investigator |
Arai Yoichi 東北大学, 医学系研究科, 教授 (50193058)
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| Co-Investigator(Kenkyū-buntansha) |
川守田 直樹 東北大学, 大学病院, 助教 (00617524)
山下 慎一 東北大学, 大学病院, 講師 (10622425)
海法 康裕 東北大学, 医学系研究科, 非常勤講師 (30447130)
三塚 浩二 東北大学, 大学病院, 講師 (80568171)
泉 秀明 東北大学, 医学系研究科, 助教 (80722545)
佐藤 琢磨 東北大学, 大学病院, 助教 (80804856)
斎藤 英郎 東北大学, 医学(系)研究科(研究院), 非常勤講師 (00466559)
並木 俊一 東北大学, 医学(系)研究科(研究院), 非常勤講師 (40400353)
中川 晴夫 東北大学, 医学(系)研究科(研究院), 非常勤講師 (80333574)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 前立腺癌 / 前立腺全摘術 / 尿失禁 / ED / QOL / 再生医学 / 機能温存 |
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| Outline of Final Research Achievements |
Prospective study demonstrated that minimal residual urethral length (mRUL) on preoperative MRI is associated with preoperative urinary function and predicts postoperative urinary continence recovery (Satake Y, Urology, 2018). Using nerve-sparing rat model we originally developed, we revealed that use of tissue sealing sheet attenuated postoperative inflammatory changes and oxidative stress and improved erectile function after cavernous nerve injury in rats（Yamashita S , J Sex Med. 2016;）. Based on the findings, randomized clinical controlled study on the efficacy of tissue sealing sheet in robot-assisted radical prostatectomy is ongoing. The interim analyses will be reported in 2018 Annual Meeting of American Urological Association. Using rat model, it was demonstrated that sacral surface therapeutic electrical stimulation increases blood flow of penis and bladder, suggesting the possible role of improving functional outcome after radical prostatectomy.
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