| Project/Area Number |
26293368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
徳永 貴広 福井大学, 医学部附属病院, 特命助教 (10464075)
野口 恵美子 筑波大学, 医学医療系, 教授 (40344882)
高林 哲司 福井大学, 医学部附属病院, 講師 (70397272)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | スギ花粉症 / HLA-DR / Apolipoprotein A4 / Dectin-1 / TSLP / IL-33 / C3a / C5a / HLA-DPB / Apolipoprotein A-IV / ヒスタミン / CpG-DNA / Hexaponda / アレルギー / 遺伝子 / 細胞・組織 / 発現制御 / 免疫学 / IgE / IL-17A / アレルギー性鼻炎 / Dectin 1 / ヒスタミン遊離 |
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| Outline of Final Research Achievements |
HLA-DPB1*02:01 and HLA-DPB1*02:02 had a protective tendency and DPB1*05:01 had a susceptible tendency for sensitization of Japanese cedar pollen. Apo A4, which is induced by sublingual immunotherapy, inhibited sneezing, nasal itching and nasal obstruction. Dectin-1 is a critical factor in the tyrosine phosphorylation in mast cells. TSLP and IL-33 are important factors in production of IgE, but not release histamine from mast cells. Serum levels of C3a, C5a and IL-A were associated with symptom scores and increased by sublingual immunotherapy.
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