Identification of osteoclast precursors that induce inflammatory bone destruction
Project/Area Number |
26293398
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Showa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小林 隆志 大分大学, 医学部, 教授 (30380520)
山田 篤 昭和大学, 歯学部, 講師 (50407558)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 歯周病 / 骨 / 破骨細胞 / LPS / 炎症 / 炎症性骨破壊 / マウス / 細胞分化 / 骨代謝 / 歯学 / 細胞・組織 / 遺伝子 / 医療・福祉 / 薬理学 / 歯 / 免疫 / 感染 / 血液 |
Outline of Final Research Achievements |
In periodontitis, osteoclast precursors differentiate into osteoclasts and resorb alveolar bone. However, the precise characteristics of the precursors are not known. We found that cells capable of osteoclast differentiation exist in bone marrow, spleen, and blood though their characteristics are significantly different. In addition, when inflammatory was induced in mice by LPS administration, cells capable of osteoclast differentiation increased in the spleen. This suggests that there are some types of the cells capable of osteoclast differentiation in the body, which is affected by inflammation, which will be a part of the mechanism in the periodontal bone destruction.
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Report
(5 results)
Research Products
(67 results)
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[Journal Article] Smad4 is required to inhibit osteoclastogenesis and maintain bone mass2016
Author(s)
Morita M, Yoshida S, Iwasaki R, Yasui T, Sato Y, Kobayashi T, Watanabe R, Oike T, Miyamoto K, Takami M, Ozato K, Deng CX, Aburatani H, Tanaka S, Yoshimura A, Toyama Y, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 35221-35221
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] nteraction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis.2016
Author(s)
Yu, J., Yun, H., Shin, B., Kim, Y., Park, E.S., Choi, S., Yu, J., Amarasekara, D.S., Kim, S., Inoue, J., Walsh, M.C., Choi, Y., Takami, M. and Rho, J.
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Journal Title
J. Biol. Chem.
Volume: 291(39)
Issue: 39
Pages: 20643-20660
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Down-regulation of Irf8 by Lyz2-cre/loxP accelerates osteoclast differentiation in vitro2016
Author(s)
Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, Kamijo R
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Journal Title
Cytotechnology
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Conditional deletion of CD98hc inhibits osteoclast development2016
Author(s)
Tsumura, H, Ito, M, Takami, M, Arai, M, Li, X.-K, Hamatani, T, Igarashi, A, Takada, S, Miyado, K, Umezawa, A, Ito, Y
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Journal Title
Biochem. Biophys. Rep
Volume: 5
Pages: 203-210
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways2015
Author(s)
Kurosawa T, Yamada A, Takami M, Suzuki D, Saito Y, Hiranuma K, Enomoto T, Morimura N, Yamamoto M, Iijima T, Shirota T, Itabe H, Kamijo R.
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Journal Title
FEBS Open Bio
Volume: 5
Issue: 1
Pages: 303-307
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
Author(s)
Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
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Journal Title
J.Biol.Chem.
Volume: 289
Issue: 22
Pages: 1-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Secretion of a truncated osteopetrosis-associated transmembrane protein 1 (OSTM1) mutant inhibits osteoclastogenesis through down-regulation of the B lymphocyte-induced maturation protein 1 (BLIMP1)-nuclear factor of activated T cells c1 (NFATc1) axis2014
Author(s)
Shin B, Yu J, Park ES, Choi S, Yu J, Hwang JM, Yun H, Chung YH, Hong KS, Choi JS, Takami M, Rho J.
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Journal Title
J Biol Chem
Volume: 289
Issue: 52
Pages: 35868-35881
DOI
Related Report
Peer Reviewed
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