Development of hydrogels with the ability to release antimicrobials for long term and their application to various resin-based materials
| Project/Area Number |
26293409
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
Imazato Satoshi 大阪大学, 歯学研究科(研究院), 教授 (80243244)
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 淳一 大阪大学, 歯学研究科(研究院), 助教 (50530490)
高橋 雄介 大阪大学, 歯学部附属病院, 講師 (60397693)
岩崎 泰彦 関西大学, 工学部, 教授 (90280990)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 歯学 / 歯科材料 / レジン / 抗菌性 / ドラッグデリバリー / 抗菌剤 / 歯科材料学 / 抗菌性材料 / ハイドロゲル |
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| Outline of Final Research Achievements |
In this study, non-biodegradable hydrogels composed of HEMA and a cross-linking monomer TMPT, to be used as a reservoir of antimicrobials, were fabricated. These novel hydrogels were found to be able to work as a carrier of cetylpyridinium chloride (CPC), enabling long-term release of CPC in a wet environment. By incorporation of CPC-loaded polyHEMA/TMPT hydrogel particles, it is possible to provide MMA-based resins or HEMA-based endodontic sealers with long-lasting antibacterial effects, keeping their physical properties in clinically acceptable level.Thus, we successfully developed a sustained antimicrobial-release system useful for achievement of reconstructive materials which exhibit long-lasting antibacterial effects.
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Report
(4 results)
Research Products
(28 results)
