Prospective cohort study on the relationship between oral health and cardiovascular disease in general urban population

• Project/Area Number: 26293411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Niigata University
• Principal Investigator: Ono Takahiro 新潟大学, 医歯学系, 教授 (30204241)
• Co-Investigator(Kenkyū-buntansha): 山本 雅章 大阪大学, 歯学研究科(研究院), 助教 (00508682) ; 小島 美樹 大阪大学, 歯学研究科(研究院), 助教 (20263303) ; 小久保 喜弘 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217) ; 関根 伸一 大阪大学, 歯学部附属病院, 助教 (70506344) ; 高阪 貴之 大阪大学, 歯学部附属病院, 医員 (40755360) ; 山鹿 義郎 新潟大学, 医歯学総合病院, 医員 (20736607) ; 小飯塚 仁美 新潟大学, 医歯学総合病院, 医員 (80783349)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 口腔健康 / 動脈硬化性疾患 / メタボリックシンドローム / 咀嚼能力 / 歯周病 / 歯学 / 循環器・高血圧 / 臨床疫学 / 生理学 / 咀嚼 / 生活習慣病

Outline of Final Research Achievements

Basic health check-up and oral examination were performed in randomly selected urban Japanese population aged 50-70 years for investigating the relationship between oral health and the risk of cardiovascular disease. Significant relationship between periodontal disease and the prevalence of metabolic syndrome (MetS) was shown with the odds ratio having periodontal disease of 2.27 in men and 1.76 in women with 4 or more MetS components comparing with no components. On the other hands, the group with declined masticatory performance had higher odds ratio having MetS comparing with the highest masticatory performance group, and such tendency was prominent in 70's years subjects. These results suggested the possibility that the prevention of periodontal disease and decline of masticatory ability contributed to the prevention of cardiovascular disease.

Research Products

• [Journal Article] Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: the Suita study. (2017)
  • Author(s): Miki Kikui, Takahiro Ono, Yoshihiro Kokubo, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Takashi Nokubi, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
  • Journal Title: Journal of Dentistry Volume: 56 Pages: 53-57
  • DOI: 10.1016/j.jdent.2016.10.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study (2017)
  • Author(s): Miki Kikui, Yoshihiro Kokubo, Takahiro Ono, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 5 Pages: 495-507
  • DOI: 10.5551/jat.33761
  • NAID: 130005631699
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A multifactorial model of masticatory performance: the Suita study (2016)
  • Author(s): Kosaka T, Ono T, Kida M, Kikui M, Yamamoto M, Yasui S, Nokubi T, Maeda Y, Kokubo Y, Watanabe M, Miyamoto Y
  • Journal Title: J Oral Rehabil Volume: 43 Issue: 5 Pages: 340-347
  • DOI: 10.1111/joor.12371
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study (2015)
  • Author(s): Miki Kikui, Takahiro Ono, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Yoko Yoshimuta, Sakae Yasui, Takashi Nokubi, Yoshinobu Maeda, Yoshihiro Kokubo, Makoto Watanabe, Yoshihiro Miyamoto
  • Journal Title: Clinical and Experimental Dental Research Volume: 1 Issue: 2 Pages: 57-62
  • DOI: 10.1002/cre2.10
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The effect of periodontal status and occlusal support on masticatory performance: the Suita study. (2014)
  • Author(s): Kosaka, T., Ono, T., Yoshimuta, Y., Kida, M., Kikui, M., Nokubi, T., Maeda, Y., Kokubo, Y., Watanabe, M., Miyamoto, Y.
  • Journal Title: Journal of Clinical Periodontology Volume: 41 Issue: 5 Pages: 497-503
  • DOI: 10.1111/jcpe.12241
  • Peer Reviewed
• [Journal Article] Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study. (2014)
  • Author(s): Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y, Miyamoto Y.
  • Journal Title: Atherosclerosis. Volume: 237(1) Issue: 1 Pages: 123-8
  • DOI: 10.1016/j.atherosclerosis.2014.08.046
  • Peer Reviewed
• [Presentation] 都市部一般住民における咀嚼能率の縦断的推移－吹田研究－ (2016)
  • Author(s): 高阪貴之，小野高裕，來田百代，菊井美希，橋本 栄，藤井克則、山本雅章，前田芳信，金田 恒，小久保喜弘，野首孝祠
  • Organizer: 第27回日本咀嚼学会学術大会
  • Place of Presentation: 広島大学医学部広仁会館（広島県広島市）
  • Year and Date: 2016-11-05
• [Presentation] 歯数の自己認識に見るオーラルリテラシーと咀嚼能率との関連－吹田研究－ (2016)
  • Author(s): 橋本 栄，小野高裕，來田百代，高阪貴之，菊井美希，藤井克則，山本雅章，野首孝祠，小久保喜弘，前田芳信
  • Organizer: 第27回日本咀嚼学会学術大会
  • Place of Presentation: 広島大学医学部広仁会館（広島県広島市）
  • Year and Date: 2016-11-05
• [Presentation] 咀嚼能力の低下とメタボリックシンドローム罹患との関係 (2016)
  • Author(s): 小野高裕，菊井美希，來田百代，高阪貴之，橋本 栄，山本雅章，藤井克則，前田芳信，野首孝祠
  • Organizer: 第23回日本歯科医学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-21
• [Presentation] 咀嚼能力のバイオマーカーとしての意味を探る - 吹田研究より (2016)
  • Author(s): 小野高裕
  • Organizer: 日本補綴歯科学会研究企画推進委員会・学術委員会合同シンポジウム「歯科補綴が担う口腔の健康と健康長寿 - 明るい超高齢社会の実現」
  • Place of Presentation: 昭和大学歯科病院（東京都）
  • Year and Date: 2016-02-21
  • Invited
• [Presentation] Masticatory performance as a novel biomarker of oral and general health (2016)
  • Author(s): Ono T
  • Organizer: International Collaborative Symposium on Development of Human Resource in Practical Oral Health and Treatment
  • Place of Presentation: Lombok (Indonesia)
  • Year and Date: 2016-01-09
  • Int'l Joint Research / Invited
• [Presentation] Relationship between objective masticatory performance and prevalence of metabolic syndrome in a Japanese general population: the Suita study (2015)
  • Author(s): Ono T, Kikui M, Kokubo Y, Kida M, Kosaka T, Yamamoto M, Watanabe M, Maeda Y, Miyamoto Y
  • Organizer: European College of Gerodontology
  • Place of Presentation: Belfast (United Kingdom)
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] 咀嚼能力の低下および歯周病とメタボリックシンドロームとの関連 ―吹田研究― (2015)
  • Author(s): 菊井美希, 小野高裕, 山本雅章, 來田百代, 高阪貴之, 橋本 栄, 藤井克則, 野首孝祠, 小久保喜弘, 前田芳信
  • Organizer: 日本咀嚼学会第26回学術大会
  • Place of Presentation: 鶴見大学会館（神奈川県横浜市）
  • Year and Date: 2015-09-26
• [Presentation] 都市部一般住民における咀嚼能率低下のリスク因子－吹田研究－ (2014)
  • Author(s): 來田百代，小野高裕，高阪貴之，菊井美希，吉牟田陽子，安井栄，山本雅章，野首孝祠，小久保喜弘，前田芳信
  • Organizer: 日本咀嚼学会第25回総会・学術大会
  • Place of Presentation: 静岡県立大学（静岡市）
  • Year and Date: 2014-09-21
• [Presentation] 歯科受診行動は都市部一般住民の咀嚼能力に影響するか？－吹田研究－ (2014)
  • Author(s): 菊井美希，小野高裕，來田百代，高阪貴之，吉牟田陽子，安井栄，山本雅章，野首孝祠，小久保喜弘，前田芳信
  • Organizer: 日本咀嚼学会第25回総会・学術大会
  • Place of Presentation: 静岡県立大学（静岡市）
  • Year and Date: 2014-09-21
• [Presentation] 機能的バイオマーカーとしての咀嚼の評価 (2014)
  • Author(s): 小野高裕
  • Organizer: 日本咀嚼学会第25回総会・学術大会
  • Place of Presentation: 静岡県立大学（静岡市）
  • Year and Date: 2014-09-21
  • Invited
• [Presentation] 異なる咬合支持域において咀嚼能率に関連する因子の検討－吹田研究 (2014)
  • Author(s): 高阪貴之，小野高裕，來田百代，菊井美希，山本雅章，前田芳信，小久保喜弘，安井栄，野首孝祠
  • Organizer: 日本老年歯科医学会第25回学術大会
  • Place of Presentation: 静岡県立大学（静岡市）
  • Year and Date: 2014-06-14
• [Presentation] Tumor necrosis factor a in saliva may be a novel marker of catorid atherosclerosis: The Suita Study (2014)
  • Author(s): Takayuki Kosaka, Yoshihiro Kokubo, Takahiro Ono, Shinichi Sekine, Momoyo Kida, Miki Kikui, Masaaki Yamamoto, Makoto Watanabe, Atsuo Amano, Yoshinobu Maeda, Yoshihiro Miyamoto
  • Organizer: XXIII European Stroke Conference
  • Place of Presentation: Nice (France)
  • Year and Date: 2014-05-08
• [Book] 老年歯科医学 (2015)
  • Author(s): 小野高裕
  • Total Pages: 467
  • Publisher: 医歯薬出版