• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of bone marrow-derived CD11b positive cells in recurrence of oral cancer

Research Project

Project/Area Number 26293431
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionYokohama City University

Principal Investigator

KIOI Mitomu  横浜市立大学, 医学部, 准教授 (30545059)

Co-Investigator(Kenkyū-buntansha) 藤内 祝  横浜市立大学, 医学研究科, 教授 (50172127)
谷口 英樹  横浜市立大学, 医学研究科, 教授 (70292555)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywordsがん微小環境 / 再発 / 血管形成 / 癌 / 血管新生 / 腫瘍微小環境 / 癌再発 / がん再発
Outline of Final Research Achievements

In the present study, we investigated the role of infiltrating CD11b+ myeloid cells in the vascularization and recurrence of oral squamous cell carcinoma (OSCC). In a xenograft mouse model, local irradiation caused vascular damage and hypoxia in the tumor and increased infiltration of CD11b+ myeloid cells. These infiltrating cells showed characteristics of M2 macrophages (M2Mφs) and are associated with the promotion of vascularization. M2Mφs promoted tumor progression in recurrence after irradiation. In addition, we found that CD11b+ myeloid cells, as well as CD206+ M2Mφs, are increased during recurrence after radiotherapy in human OSCC specimens. Our findings indicate that polarization of M2Mφs derived from recruited CD11b+ cells into tumor after irradiation contributes vascularization leading to recurrence of OSCC.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation.2016

    • Author(s)
      Okubo M, Kioi M, Nakashima H, Sugiura K, Mitsudo K, Aoki I, Taniguchi H, Tohnai I.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27548-27548

    • DOI

      10.1038/srep27548

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] M2-Polarized Macrophages Contribute to Neovasculogenesis, Leading to Relapse of Oral Cancer Following Radiation.2017

    • Author(s)
      kioi M
    • Organizer
      10th World Cancer Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 指名報告 口腔癌新規治療法の開発 ―微小環境ニッチを標的として―.2017

    • Author(s)
      來生 知
    • Organizer
      第71回日本口腔科学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 口腔癌再発・転移に関わる微小環境変化と骨髄細胞の役割2016

    • Author(s)
      來生 知
    • Organizer
      日本口腔腫瘍学会
    • Place of Presentation
      横浜市開港記念会館(神奈川県横浜市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi