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Molecular mechanisms of nerve-vessel-bone network

Research Project

Project/Area Number 26293432
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionSaitama Medical University

Principal Investigator

SATO Tsuyoshi  埼玉医科大学, 医学部, 准教授 (60406494)

Co-Investigator(Kenkyū-buntansha) 臼井 通彦  九州歯科大学, 歯学部, 准教授 (10453630)
竹田 秀  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30376727)
水野 洋介  埼玉医科大学, 医学部, 助教 (30406532)
古株 彰一郎  九州歯科大学, 歯学部, 准教授 (30448899)
松本 征仁  埼玉医科大学, 医学部, 講師 (90321819)
Co-Investigator(Renkei-kenkyūsha) OKAZAKI Yasushi  埼玉医科大学, 医学部, 教授 (80280733)
SUDA Tatsuo  埼玉医科大学, 医学部, 客員教授 (90014034)
NISHIHARA Tatsuji  九州歯科大学, 歯学部, 教授 (80192251)
YODA Testuya  埼玉医科大学, 医学部, 教授 (60242210)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsnetrin-4 / semaphorin 3A / 骨細胞 / 血管内皮細胞 / 破骨細胞 / 骨・神経・血管 / 骨減少症 / ネットワーク機構 / 骨芽細胞 / 神経芽細胞 / ネットワーク / 分化 / 遺伝子網羅的解析 / 遊走能 / 分化能 / CDK6 / 骨代謝 / 血管系 / 神経系
Outline of Final Research Achievements

Bone is a highly vascularized organ, thus angiogenesis appears a vital process during bone remodeling. However, the role of vascular systems in bone remodeling and the effect of Sema3A on dendritic processes of osteocyte cell line are not well understood.
Here we show that netrin-4 inhibits osteoclast differentiation in vitro and in vivo. Co-cultures of bone marrow macrophages with vascular endothelial cells markedly inhibited osteoclast differentiation. Administration of netrin-4 prevented bone loss in an osteoporosis mouse model by decreasing the osteoclast number. We also found that Sema3A regulates dendrites of osteocytes in association with downregulation of Cdk6.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Semaphorin 3A Promotes Dendrite Elongation of Osteocytes in Association with Down-regulation of CDK6.2016

    • Author(s)
      Niimura M, Sato T, Enoki Y, Okubo M, Kokabu S, Takeda S, Yoda T.
    • Journal Title

      In Vivo

      Volume: 30 Pages: 231-236

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo.2014

    • Author(s)
      Matsumoto, Masahiko Okubo, Keisuke Nakashima, Masayuki Yamato, Teruo Okano, Toru Fukuda, Dai Chida, Yuuki Imai, Hisataka Yasuda, Tatsuji Nishihara, Masumi Akita, Hiromi Oda, Yasushi Okazaki, Tatsuo Suda, Tetsuya Yoda
    • Journal Title

      FEBS Lett.

      Volume: 588 Issue: 14 Pages: 2262-2269

    • DOI

      10.1016/j.febslet.2014.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 骨芽細胞と神経芽細胞は相互に分化を促進させる2016

    • Author(s)
      塘田健人、佐藤毅、大久保正彦、榎木祐一郎、古株彰一郎、依田哲也
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Netrin4を介した血管内皮細胞による新たな骨代謝調節機構と骨粗鬆症に対する臨床応用2014

    • Author(s)
      榎木祐一郎,佐藤毅,林直樹,北村智久,大久保正彦,古株彰一郎,福島洋介,新村昌弘,依田哲也
    • Organizer
      第68回日本口腔科学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Book] Vascular endothelial cells inhibitosteoclast differentiation via not osteoprotegerin but netrin-42015

    • Author(s)
      Enoki Y, Sato T, Yumoto M, Ikami, E, Kitamura T, Hayashi N, Nakanoka C, Okubo M, Sano Y, Fukushima Y, Kokabu S, Yoda T
    • Total Pages
      2
    • Publisher
      Japanese Stomatological society
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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