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Development of a novel diagnosis system for periodontal disease by objective biochemical laboratory tests for salivary biomarkers.

Research Project

Project/Area Number 26293442
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Social dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

ITO Hiro-O  徳島大学, 大学院医歯薬学研究部, 教授 (40213079)

Co-Investigator(Kenkyū-buntansha) 佐野 茂樹  徳島大学, 大学院医歯薬学研究部, 教授 (20226038)
安細 敏弘  九州歯科大学, 歯学部, 教授 (80244789)
葭原 明弘  新潟大学, 医歯学系, 教授 (50201033)
Co-Investigator(Renkei-kenkyūsha) TAMAKI Naofumi  徳島大学, 大学院医歯薬学研究部, 准教授 (20335615)
FUKUI Makoto  徳島大学, 大学院医歯薬学研究部, 助教 (50325289)
YAMASHITA Yoshihisa  九州大学, 大学院歯学研究科, 教授 (20192403)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords予防歯科学 / 歯周予防学 / 唾液検査 / 歯科口腔保健 / 歯肉炎
Outline of Final Research Achievements

To take measures against periodontal disease which shows a high prevalence rate of >80% of adults, it is important to suppress gingivitis in younger generations. Diagnosis of gingivitis is currently given subjectively by dentists, and no objective diagnostic criteria; this situation prohibit proposal of specific measures against this disease. This study was conducted by collaboration of 3 independent laboratories in different universities and a health examination system by objective biochemical laboratory tests for salivary biomarkers was developed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model.2016

    • Author(s)
      Tamaki N, Orihuela-Campos RC, Fukui M, Ito HO.
    • Journal Title

      Oxid Med Cell Longev.

      Volume: 2016 Pages: 5679040-12

    • NAID

      120005775421

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 歯肉溝液中の炎症関連バイオマーカーと糖尿病・腎機能マーカーとの関連性.2016

    • Author(s)
      玉木直文,松尾 亮,水野昭彦,正木文浩,中川 徹,鈴木雅博, 福井 誠,谷口隆司,三宅達郎,伊藤博夫.
    • Journal Title

      口腔衛生会誌

      Volume: 66 Pages: 316-321

    • NAID

      130005156679

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 歯肉溝液中の炎症関連バイオマーカーと糖尿病,腎機能との関連性2016

    • Author(s)
      玉木直文,松尾 亮,水野昭彦,正木文浩,中川 徹,鈴木雅博,福井 誠,谷口隆司,三宅達郎,伊藤博夫.
    • Journal Title

      口衛生会誌

      Volume: 66

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between arteriosclerosis and periodontal condition assessed by lactoferrin and alpha1-antitrypsin levels in gingival crevicular fluid.2015

    • Author(s)
      Hayashi S, Yamada H, Fukui M, Ito H-O, Sata M
    • Journal Title

      International Heart Journal

      Volume: 56 Pages: 639-643

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Influence of infection with Porphyromonas gingivalis on relationship between atherosclerosis and anti-phosphorylcholine antibody.2015

    • Author(s)
      Makoto Fukui, Rita Orihuela-Campos, Naofumi Tamaki and Hiro-O Ito.
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病教育入院患者における歯肉溝液中の炎症関連バイオマーカーの経時的変化2015

    • Author(s)
      鈴木雅博,水野昭彦,松尾 亮,玉木直文,福井 誠,伊藤博夫
    • Organizer
      第26回近畿・中国・四国 口腔衛生学会総会
    • Place of Presentation
      山口県歯科医師会館(山口県・山口市)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 市民検診と糖尿病患者データにおける歯肉溝浸出液バイオマーカーの比較検討2015

    • Author(s)
      水野昭彦,松尾 亮,鈴木雅博,玉木直文,福井 誠,三木かなめ, 松瀬亮一,伊藤博夫
    • Organizer
      第64回日本口腔衛生学会
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Book] 第2編,・第2章 歯周病予防, 「口腔保健・予防歯科学」2017

    • Author(s)
      伊藤博夫
    • Total Pages
      303
    • Publisher
      医歯薬出版社
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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