Theories and applications of semiparametric inferences for time-to-event data with incomplete data

• Project/Area Number: 26330032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: Kagoshima University (2016); Hirosaki University (2014-2015)
• Principal Investigator: Sugimoto Tomoyuki 鹿児島大学, 理工学域理学系, 教授 (70324829)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統計的推測 / 生存解析 / 統計数学 / セミパラメトリック推測 / コピュラモデル / ログランク統計量 / 相対生存モデル / Laplace近似 / セミパラメトリック / Laplace原理 / 不完全観測データ / Cox回帰モデル / セミ競合リスク / 相対生存率 / 特異値分解 / 打ち切りデータ / セミ競合リスク問題

Outline of Final Research Achievements

In this research, we studied the fundamental theory, statistical applications and their useful developments for the semi-parametric inferences when analyzing time-to-event data obtained with incomplete observations, with the intention of extending the Cox regression model often used in statistical analysis of survival data (typically, life-time). We developed some useful tools for data analysis matched with the model characteristics, considering an extension of the Cox model and counting process model including important phenomenons in practice.

Research Products

• [Journal Article] Sizing clinical trials when comparing bivariate time-to-event outcomes (2017)
  • Author(s): Sugimoto T, Hamasaki T, Evans S.R., Sozu T.
  • Journal Title: Statistics in Medicine Volume: 36 Issue: 9 Pages: 1363-1382
  • DOI: 10.1002/sim.7225
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Group-sequential strategies in clinical trials with multiple co-primary outcomes (2015)
  • Author(s): Hamasaki H, Asakura K, Evans, SR, Sugimoto T, Sozu T
  • Journal Title: Statistics in Biopharmaceutical Research Volume: 7 Issue: 1 Pages: 36-54
  • DOI: 10.1080/19466315.2014.1003090
  • NAID: 120005619770
  • Peer Reviewed
• [Journal Article] On the convergence of observed partial likelihood under incomplete data with two class possibilities (2014)
  • Author(s): Sugimoto, T.
  • Journal Title: Open Journal of Statistics Volume: 4 Issue: 02 Pages: 118136-118136
  • DOI: 10.4236/ojs.2014.42012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sample size determination in group-sequential clinical trials with two co-primary endpoints (2014)
  • Author(s): Asakura, K., Hamasaki, T., Sugimoto, T., Hayashi, K., Evans, S., Sozu T
  • Journal Title: Statistics in Medicine Volume: (First published online) Issue: 17 Pages: 2897-2913
  • DOI: 10.1002/sim.6154
  • Peer Reviewed / Open Access
• [Presentation] Sizing clinical trials with two survival outcomes (2016)
  • Author(s): Sugimoto T, Hamasaki T., Evans SR, Sozu T.
  • Organizer: The 25th South Taiwan Statistics Conference
  • Place of Presentation: 高雄 (台湾)
  • Year and Date: 2016-06-24
  • Int'l Joint Research / Invited
• [Presentation] Sizing clinical trials when comparing two interventions using two time-to-event outcomes (2015)
  • Author(s): T.Sugimoto, T.Hamasaki, S.R. Evans, T. Sozu
  • Organizer: Joint Statistical Meetings 2015
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-08-10
  • Int'l Joint Research
• [Presentation] 切替を含む無作為化割付された治療効果の推定法に関して (2014)
  • Author(s): 谷内颯樹・杉本知之
  • Organizer: 日本計算機統計学会第28回シンポジム
  • Place of Presentation: 沖縄科学技術大学院大学
  • Year and Date: 2014-11-14 – 2014-11-15
• [Presentation] 生存時間樹木法に基づく層別ログランク検定 (2014)
  • Author(s): 丸尾和司・杉本知之
  • Organizer: 日本計算機統計学会第28回シンポジム
  • Place of Presentation: 沖縄科学技術大学院大学
  • Year and Date: 2014-11-14 – 2014-11-15