| Project/Area Number |
26340042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
魏 民 大阪市立大学, 大学院医学研究科, 准教授 (70336783)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 1,2-ジクロロプロパン / 動物実験モデル / 発がん性 / 二段階発がん / 環境 / 癌 / 病理学 / プロテオーム / ゲノム |
|---|
| Outline of Final Research Achievements |
In this study, 1,2-dichloropropane (1,2-DCP) and toxicity were investigated using an animal experiment model. As a result, bile duct carcinogenicity was not observed in mouse, rat and hamster in animal test with single exposure of 1,2-DCP and DCM. However, co-exposures of 1,2-DCP and DCM revealed a stronger liver carcinogenic potential compared to single exposure to 1,2-DCP. In addition, it was suggested that as a mechanism of tumor development, a variety of signaling pathways are activated by increased expression of cell proliferation-related factors.
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