| Project/Area Number |
26350157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nara Medical University |
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Principal Investigator |
KUBO KAORU 奈良県立医科大学, 医学部, 准教授 (20254493)
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| Co-Investigator(Kenkyū-buntansha) |
友田 恒一 奈良県立医科大学, 医学部, 病院教授 (90364059)
田中 康仁 奈良県立医科大学, 医学部, 教授 (30316070)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 関節リウマチ / 喫煙 / シンバイオテイクス / 腸内細菌叢 |
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| Outline of Final Research Achievements |
An immunologically caused paw swelling and the decrease of bone density in the adjuvant arthritis were significantly inhibited by taking the diet including 2% glutamine, 3.2% polydextrose, 3% lactulose and 5% Bifidobacterium lungum for 8 weeks. This diet intake improved a reduced Firmicutes to Bacteroidetes ratio in cecal content. Cigarette smoking exposure for 8 weeks increased an immunologically caused paw swelling. The diet including 2% glutamine, 1.6% polydextrose, 0.48% lactulose and 5% Bifidobacterium lungum significantly inhibited this increased paw swelling. The above-mentioned result suggested improvement of the rheumatoid arthritis by symbiotic effects of glutamine, polydextrose, lactulose and Bifidobacterium lungum via improving an intestinal dysbiosis.
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