• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Glutamine, dietary fiber, oligosaccharide and Bifidobacterium lungum exert symbiotic effects on adjuvant arthritis in rats.

Research Project

Project/Area Number 26350157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNara Medical University

Principal Investigator

KUBO KAORU  奈良県立医科大学, 医学部, 准教授 (20254493)

Co-Investigator(Kenkyū-buntansha) 友田 恒一  奈良県立医科大学, 医学部, 病院教授 (90364059)
田中 康仁  奈良県立医科大学, 医学部, 教授 (30316070)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords関節リウマチ / 喫煙 / シンバイオテイクス / 腸内細菌叢
Outline of Final Research Achievements

An immunologically caused paw swelling and the decrease of bone density in the adjuvant arthritis were significantly inhibited by taking the diet including 2% glutamine, 3.2% polydextrose, 3% lactulose and 5% Bifidobacterium lungum for 8 weeks. This diet intake improved a reduced Firmicutes to Bacteroidetes ratio in cecal content. Cigarette smoking exposure for 8 weeks increased an immunologically caused paw swelling. The diet including 2% glutamine, 1.6% polydextrose, 0.48% lactulose and 5% Bifidobacterium lungum significantly inhibited this increased paw swelling. The above-mentioned result suggested improvement of the rheumatoid arthritis by symbiotic effects of glutamine, polydextrose, lactulose and Bifidobacterium lungum via improving an intestinal dysbiosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi