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Elucidation of the mechanisms by which neurogenesis is impaired in dyslipidemic patients

Research Project

Project/Area Number 26350921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionNational Defense Medical College

Principal Investigator

Ishizuka Toshiaki  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 (30399117)

Co-Investigator(Kenkyū-buntansha) 鈴木 豪  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 薬理学, 講師 (50649035)
渡辺 康裕  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 薬理学, 名誉教授 (90127324)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経前駆細胞 / 神経分化 / 酸化LDL / LOX-1 / PKC / Aktリン酸化 / CREBリン酸化 / Aktリン酸化 / 神経幹細胞 / 酸化LDL受容体
Outline of Final Research Achievements

We revealed that stimulation with oxidized LDL (ox-LDL) significantly suppressed the differentiation of mouse neural progenitor cells into neural cells. In addition, it was found that the effects of ox-LDL is due to the activation of LOX-1 which activates PKC and inhibits the phosphorylation of Akt and CREB. Thus, the modulation of LOX-1 may ameliorate the impaired neurogenesis and neuropsychiatric function in dyslipidemic patients.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Tumor growth limited to subcutaneous site vs tumor growth in2017

    • Author(s)
      Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjyo Y, Ichinose T, Tokuno S, Ishizuka T, et al.
    • Journal Title

      Oncology Reports

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 幹細胞機能に影響を及ぼす細胞内機能の解明と再生医療への応用2016

    • Author(s)
      石塚 俊晶
    • Journal Title

      防衛医科大学校雑誌

      Volume: 41 Pages: 47-47

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Diagnostic performance of measuring antibodies to the glycopeptidolipid core antigen specific to Mycobacterium avium complex in patients with rheumatoid arthritis: class FormattedString { value: Results from a cross-sectional observational study }2015

    • Author(s)
      Hirose W, Uchiyama T, Nemoto A, Harigai M, Itoh K, Ishizuka T, Matsumoto M, Yamaoka K, Nanki T
    • Journal Title

      Arthritis Research and Therapy

      Volume: 17 Issue: 1 Pages: 273-273

    • DOI

      10.1186/s13075-015-0787-y

    • URL

      https://localhost/en/publications/1c1b9ea6-0b15-4f18-9b1a-098db2c56589

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimulation of 5-hydroxytryptamine 4 receptor enhnaces differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2014

    • Author(s)
      T. Ishizuka, H. Goshima, A. Ozawa, Y. Watanabe
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 41 Issue: 5 Pages: 345-350

    • DOI

      10.1111/1440-1681.12224

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of beta-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells.2014

    • Author(s)
      Ishizuka T, Goshima H, Ozawa A, Watanabe Y.
    • Journal Title

      Eur J Pharmacol

      Volume: 740 Pages: 28-34

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 多能性幹細胞の機能調節に関わる細胞膜受容体2014

    • Author(s)
      石塚 俊晶、渡辺 康裕
    • Journal Title

      日本薬理学雑誌

      Volume: 144 Pages: 13-16

    • NAID

      130004437199

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 脂質異常症における神経新生障害の機序解明:酸化LDL刺激は神経前駆細胞の分化を抑制する2017

    • Author(s)
      石塚 俊晶、佐藤 泰司、野村 さやか、小澤 亜也子、勝浦 美枝子
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 代謝性疾患治療を指向したLXRbeta選択的なアゴニストの創製2017

    • Author(s)
      野村 さやか、梅田 香織、石塚 俊晶、槇島 誠、橋本 祐一、石川 稔
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小児への麻酔曝露が自閉症発症リスクへ与える影響2017

    • Author(s)
      嶋田 哲也、佐藤 泰司、神尾 陽子、中村 好宏、中島 宏、赤井 亮介、湯舟 晋也、風間 富栄、石塚 俊晶
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] アデノシン分解酵素の神経保護作用2017

    • Author(s)
      太田 宏之、田村 吏沙、佐藤 泰司、丹生谷 正史、野々山 恵章、石塚 俊晶、西田 育弘
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] BK channel activation at spinal microglia is important for the induction of neuropathic pain in mice.2016

    • Author(s)
      Morohashi T, Itakura S, Hayashi Y, Kawaguchi Y, Nakanishi H, Nakata T, Ishizuka T, Meredith AL, Satoh Y.
    • Organizer
      16 th World Congress on Pain
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of extracellular signal-regulated protein kinase 2 (ERK2) in the peripheral nervous system for the mechanism of pain transmission.2016

    • Author(s)
      Itakura S, Morohashi T, Otsubo Y, Endo S, Satoh T, Wood JN, Ishizuka T, Satoh Y.
    • Organizer
      16th World Congress of Pain
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of G-coupled receptor-dependent cyclic AMP/PKA siganling pathway on neural differentiation of mouse iPS cells.2016

    • Author(s)
      Ishizuka T, Ozawa A, Katsuura M, Satoh Y.
    • Organizer
      ISSCR 2016
    • Place of Presentation
      San Francisco
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Wnt3a, TNFalpha, or nicotine on differentiation of human intestinal stem cells into intestinal epithelial cells2016

    • Author(s)
      Ishizuka T, Ozawa A, Katsuura M, Satoh Y.
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 発達期の神経発達における細胞外情報伝達制御キナーゼ(ERK)の役割2016

    • Author(s)
      佐藤泰司、湯舟晋也、遠藤昌吾、風間富栄、石塚俊晶
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of TNF-alpha and nicotine on differentiation of human endodermal progenitor cells into intestinal epithelial cells2015

    • Author(s)
      Ishizuka T, Ozawa A, Sado A, Arata M, Watanabe Y.
    • Organizer
      International Society for Stem Cell Research 2015 Annual Meeting
    • Place of Presentation
      Stockholm, SWEDEN
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス人工多能性幹細胞の神経前駆細胞への分化におけるG蛋白質共役型受容体を介したcAMP/PKAシグナル伝達系の役割2015

    • Author(s)
      石塚 俊晶、小澤 亜也子、新田 宗光、渡辺 康裕
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Involvement of cannabinoid receptors or muscarinic acetylcholine receptors on differentiation into neural progenitor cells in mouse induced pluripotent stem cells.2014

    • Author(s)
      Ishizuka T, Ozawa A, Arata M, Watanabe Y.
    • Organizer
      43th Annual Meeting of Society for Neuroscinece
    • Place of Presentation
      アメリカ、ワシントン
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ムスカリン型アセチルコリン受容体刺激は、cAMP/PKAシグナル伝達系を阻害してマウス人工多能性幹細胞の神経前駆細胞への分化を抑制する2014

    • Author(s)
      石塚 俊晶、小澤 亜也子、新田 宗光、渡辺 康裕
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学医学部
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス人工多能性幹細胞の増殖および神経前駆細胞への分化に対するムスカリン型アセチルコリン受容体の関与2014

    • Author(s)
      石塚 俊晶、小澤 亜也子、新田 宗光、渡辺 康裕
    • Organizer
      第57回日本神経化学会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29
    • Related Report
      2014 Research-status Report
  • [Presentation] The stimulation of muscarinic acetylcholine receptors inhibits differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2014

    • Author(s)
      Watanabe Y, Ishizuka T, Ozawa A, Arata M.
    • Organizer
      16th Congress of European Neuroendocrine Association
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Stimualtion with beta-adrenoceptors enhances differentiation of human induced pluripotent stem cells into cardiovascular progenitor cells via PKA-dependent p38 MAPK activation.2014

    • Author(s)
      Watanabe Y, Ishizuka T, Ozawa A, Arata M.
    • Organizer
      17th World Congress of Basic and Clinical Pharmacology
    • Place of Presentation
      南アフリカ共和国
    • Year and Date
      2014-07-13
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス人工多能性幹細胞の内胚葉系前駆細胞および肝細胞への分化に対するニコチンの影響2014

    • Author(s)
      石塚 俊晶、小澤 亜也子、新田 宗光、渡辺 康裕
    • Organizer
      第130回日本薬理学会関東部会
    • Place of Presentation
      東京、星薬科大学
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Involvement of 5-HT4 receptor or cannabinoid receptors on differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2014

    • Author(s)
      Ishizuka T, Ozawa A, Arata M, Watanabe Y.
    • Organizer
      12th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      カナダ、バンクーバー
    • Year and Date
      2014-06-18
    • Related Report
      2014 Research-status Report
  • [Book] Regulation of Signal Transduction in Human Cell Research: Role of the receptor-mediated signaling pathways on the proliferation and differentiation of pluripotent stem cells2017

    • Author(s)
      Ishizuka T
    • Publisher
      Springer-Nature
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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