Assembling Methods of Functional Molecules for Development of Muti-modarity Molecular Probes
| Project/Area Number |
26350971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Yoshida Suguru 東京医科歯科大学, 生体材料工学研究所, 准教授 (10583750)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ケミカルバイオロジー / 有機化学 / 分子プローブ / アジド / クリック反応 |
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| Outline of Final Research Achievements |
"Molecular probe" which is a multifunctional molecule for advancing life science research has attracted attention as an important tool. However, synthesis of multifunctional molecules such as multi-modality probes is not easy. We studied on multi-click chemistry to enable facile preparation of a variety of multi-functional molecules by sequential use of click reactions, which are widely used as a reliable method to conjugate two molecules. As the results, we successfully developed a method to transiently protect the clickability of cyclic alkyne moieties toward azides. This method enabled the synthesis of cyclic alkynes bearing a functional group from functional azides via a terminal alkyne-selective click reaction.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Concise Synthesis of v‐Coelenterazines2015
Author(s)
Takamitsu Hosoya, Rie Iimori, Suguru Yoshida, Yuto Sumida, Yuiko Sahara-Miura, Jun-ichi Sato, Satoshi Inouye
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Journal Title
Organic Letters
Volume: 17
Issue: 15
Pages: 3888-3891
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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