| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
"Molecular probe" which is a multifunctional molecule for advancing life science research has attracted attention as an important tool. However, synthesis of multifunctional molecules such as multi-modality probes is not easy. We studied on multi-click chemistry to enable facile preparation of a variety of multi-functional molecules by sequential use of click reactions, which are widely used as a reliable method to conjugate two molecules. As the results, we successfully developed a method to transiently protect the clickability of cyclic alkyne moieties toward azides. This method enabled the synthesis of cyclic alkynes bearing a functional group from functional azides via a terminal alkyne-selective click reaction.
|
