Gender- and pharmacogenetics-based prevention of adverse drug events and lifestyle-related diseases: An approach to personalized medicine

• Project/Area Number: 26360049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gender
• Research Institution: Kumamoto University
• Principal Investigator: NAKAGAWA Kazuko 熊本大学, 大学院生命科学研究部(薬), 客員教授 (20284747)
• Co-Investigator(Kenkyū-buntansha): 猿渡 淳二 熊本大学, 大学院生命科学研究部(薬), 准教授 (30543409) ; 鬼木 健太郎 熊本大学, 大学院生命科学研究部(薬), 助教 (00613407)
• Co-Investigator(Renkei-kenkyūsha): HOKIMOTO Seiji 熊本大学, 大学院生命科学研究部(医), 准教授 (30535638)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 個別化医療 / 性差医療 / 臨床薬理遺伝学 / 生活習慣病 / 心血管疾患 / 糖尿病 / 薬物有害反応

Outline of Final Research Achievements

The gender and/or pharmacogenetic differences in the risks of lifestyle-related diseases were investigated by cross-sectional, case-control and longitudinal studies, including more than 10,000 subjects with/without lifestyle-related diseases. Additionally, subgroup analyses by gender for the Drug Event Monitoring project of the Japan Pharmaceutical Association were conducted.
A cytochrome P450 (CYP) 2C19 poor metabolizer (PM) was an independent risk factor for microangiopathies, i.e. diabetic retinopathy and microvascular angina, in women only. Moreover, CYP2C19 genotype was associated with an increased risk of cardiovascular events following stent implantation in Japanese patients. CYP2C19 PM was shown to affect epoxyeicosatrienoic acids-based defensive mechanisms and the efficacy of clopidogrel. Potential new associations between the risks of lifestyle-related diseases and/or adverse drug events and gender and/or the genotypes of ALDH2, GGT1, GSTK1 or SOD2 were also demonstrated.

Research Products

• [Journal Article] Common variants of HNF1A gene are associated with diabetic retinopathy and poor glycemic control in normal-weight Japanese subjects with type 2 diabetes mellitus. (2017)
  • Author(s): Morita K, Saruwatari J, Tanaka T, Oniki K, Kajiwara A, Miyazaki H, Yoshida A, Jinnouchi H, Nakagawa K.
  • Journal Title: J Diabetes Complications. Volume: 31 Issue: 2 Pages: 483-488
  • DOI: 10.1016/j.jdiacomp.2016.06.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes. (2017)
  • Author(s): Uno Y, Takata R, Kito G, Yamazaki H, Nakagawa K, Nakamura Y, Kamataki T, Katagiri T.
  • Journal Title: Drug Metab Pharmacokinet. Volume: 32 Issue: 1 Pages: 100-107
  • DOI: 10.1016/j.dmpk.2016.10.409
  • NAID: 210000169552
  • Peer Reviewed
• [Journal Article] Safety analysis of zolpidem in elderly subjects 80 years of age or older: Adverse event monitoring in Japanese subjects. (2016)
  • Author(s): Kajiwara A, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Morita K, Oniki K, Saruwatari J & Nakagawa K.
  • Journal Title: Aging & mental health Volume: 印刷中 Issue: 6 Pages: 611-615
  • DOI: 10.1080/13607863.2015.1031640
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of platelet-derived thrombogenicity by the total thrombus-formation analysis system in coronary artery disease patients on antiplatelet therapy. (2016)
  • Author(s): Arima Y, Kaikita K, Ishii M, Ito M, Sueta D, Oimatsu Y, Sakamoto K, Tsujita K, Kojima S, Nakagawa K, Hokimoto S, Ogawa H.
  • Journal Title: J Thromb Haemost. Volume: 14 Issue: 4 Pages: 850-859
  • DOI: 10.1111/jth.13256
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease (2016)
  • Author(s): Oniki K, Morita K, Watanabe T, Kajiwara A, Otake K, Nakagawa K, Sasaki Y, Ogata Y, Saruwatari J.
  • Journal Title: Nutr Diabetes. Volume: 6 Issue: 5 Pages: e210-e210
  • DOI: 10.1038/nutd.2016.17
  • Peer Reviewed / Open Access
• [Journal Article] Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction. (2016)
  • Author(s): Mizuno Y, Hokimoto S, Harada E, Kinoshita K, Nakagawa K, Yoshimura M, Ogawa H, Yasue H.
  • Journal Title: J Am Heart Assoc. Volume: 5 Issue: 5
  • DOI: 10.1161/jaha.116.003247
  • Peer Reviewed
• [Journal Article] Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder. (2016)
  • Author(s): Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 310
  • Peer Reviewed
• [Journal Article] Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes. (2016)
  • Author(s): Kajiwara A, Kita A, Saruwatari J, Miyazaki H, Kawata Y, Morita K, Oniki K, Yoshida A, Jinnouchi H, Nakagawa K.
  • Journal Title: J Diabetes Res. Volume: - Pages: 4626382-4626382
  • DOI: 10.1155/2016/4626382
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Effect of <i>Yokukansan</i>, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers (2016)
  • Author(s): Soraoka H, Oniki K, Matsuda K, Ono T, Taharazako K, Uchiyashiki Y, Kamihashi R, Kita A, Takashima A, Nakagawa K, Yasui-Furukori N, Kadowaki D, Miyata K, Saruwatari J.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 9 Pages: 1468-1474
  • DOI: 10.1248/bpb.b16-00248
  • NAID: 130005262324
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction. (2016)
  • Author(s): Tabata N, Sueta D, Akasaka T, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Hokimoto S.
  • Journal Title: PLoS One. Volume: 11 Issue: 11 Pages: e0166240-e0166240
  • DOI: 10.1371/journal.pone.0166240
  • Peer Reviewed / Open Access
• [Journal Article] Association of CYP2C19 variants and epoxyeicosatrienoic acids on patients with microvascular angina. (2016)
  • Author(s): Akasaka T, Sueta D, Arima Y, Tabata N, Takashio S, Izumiya Y, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Matsui K, Hokimoto S.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 311 Issue: 6 Pages: H1409-H1415
  • DOI: 10.1152/ajpheart.00473.2016
  • Peer Reviewed
• [Journal Article] Prescription of triazolam for the elderly in Japan: A sub-analysis of the drug event monitoring project by the Japan Pharmaceutical Association. (2016)
  • Author(s): Kajiwara A, Ishizuka T, Yamamura M, Murase M, Koda H, Hirota S, Morita K, Oniki K, Saruwatari J, Nakagawa K.
  • Journal Title: Clin Neuropsychopharmacol Ther. Volume: 7 Pages: 48-53
  • NAID: 130005279585
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Helicobacter Pylori-seropositivity along with genetic and environmental factors predicts clinical outcome after acute coronary syndrome. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 212 Pages: 54-56
  • DOI: 10.1016/j.ijcard.2016.03.034
  • Peer Reviewed / Open Access
• [Journal Article] Gender Differences in the Impact of CYP2C19 Polymorphisms and Low-Grade Inflammation on Coronary Microvascular Disorder. (2016)
  • Author(s): Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H.
  • Journal Title: Am. J. Physiol. Heart Circ. Volume: - Issue: 11 Pages: H1494-H1500
  • DOI: 10.1152/ajpheart.00911.2015
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study. (2016)
  • Author(s): Oniki K, Kamihashi R, Tomita T, Ishioka M, Yoshimori Y, Osaki N, Tsuchimine S, Sugawara N, Kajiwara A, Morita K, Miyata K, Otake K, Nakagawa K, Ogata Y, Saruwatari J, Yasui-Furukori N.
  • Journal Title: Psychiatry Res. Volume: 239 Pages: 190-195
  • DOI: 10.1016/j.psychres.2016.03.025
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Yamabe H, Matsui K, Ogawa H.
  • Journal Title: Clin Trials Regul Sci Cardiol Volume: 17 Pages: 9-14
  • Peer Reviewed / Open Access
• [Journal Article] Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. (2016)
  • Author(s): Noai M, Soraoka H, Kajiwara A, Tanamachi Y, Oniki K, Nakagawa K, Ishitsu T, Saruwatari J.
  • Journal Title: Acta Neurol. Scand. Volume: 133 Issue: 3 Pages: 216-223
  • DOI: 10.1111/ane.12473
  • Peer Reviewed
• [Journal Article] Patients with both CYP2C19 loss-of-function allele and peripheral endothelial dysfunction are significantly correlated with adverse cardiovascular events following coronary stent implantation. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Yuichiro A, Sakamoto K, Yamamoto E, Tsujita K, Izumiya Y, Yamamuro M, Kojima S, Koichi K, Kumagae N, Morita K, Oniki K, Nakagawa K, Matsui K, Ogawa H.
  • Journal Title: J Cardiol. Volume: 67 Issue: 1 Pages: 104-109
  • DOI: 10.1016/j.jjcc.2015.03.010
  • Peer Reviewed
• [Journal Article] Impact of esomeprazole on platelet reactivity and clinical outcome according to CYP2C19 genotype in coronary heart disease patients during dual antiplatelet therapy. (2015)
  • Author(s): Hokimoto S, Akasaka T, Tabata T, Arima Y, Tsujita K, Sakamoto K, Kaikita K, Morita K, Kumagae N, Yamamoto E, Oniki K, Nakagawa K, Ogawa H.
  • Journal Title: Thromb. Res. Volume: 135 Issue: 6 Pages: 1081-1086
  • DOI: 10.1016/j.thromres.2015.03.033
  • Peer Reviewed
• [Journal Article] Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy. (2015)
  • Author(s): Jinnouchi H, Morita K, Takahiro T, Kajiwara A, Kawata Y, Oniki K, Saruwatari J, Nakagawa K, Otake K, Ogata Y, Yoshida A, Hokimoto S, Ogawa H.
  • Journal Title: Cardiovasc Diabetol Volume: 14 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s12933-015-0212-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: A pilot study. (2015)
  • Author(s): Morita K, Masuda N, Oniki K, Saruwatari J, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Toxicol. Lett. Volume: 236 Issue: 2 Pages: 117-122
  • DOI: 10.1016/j.toxlet.2015.05.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A functional variant in the γ-glutamyl transferase (GGT) 1 gene is associated with airflow obstruction in smokers. (2015)
  • Author(s): Morita K, Masuda N, Tanaka T, Saruwatari J, Oniki K, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Clin. Chem. Lab. Med. Volume: 53 Issue: 12
  • DOI: 10.1515/cclm-2015-0331
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects. (2015)
  • Author(s): Oniki K, Saruwatari J, Izuka T, Kajiwara A, Morita K, Sakata M, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: PLoS ONE Volume: 10 Issue: 7 Pages: e0132640-e0132640
  • DOI: 10.1371/journal.pone.0132640
  • Peer Reviewed / Open Access
• [Journal Article] Higher risk of sulfonylurea-associated hypoglycemic symptoms in women with type 2 diabetes mellitus. (2015)
  • Author(s): Kajiwara A, Kita A, Saruwatari J, Oniki K, Morita K, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Nakagawa K.
  • Journal Title: Clin Drug Investig Volume: 35 Issue: 9 Pages: 593-600
  • DOI: 10.1007/s40261-015-0314-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. (2015)
  • Author(s): Nakashima H, Oniki K, Nishimura M, Ogusu N, Shimomasuda M, Ono T, Matsuda K, Yasui-Furukori N, Nakagawa K, Ishitsu T, Saruwatari J.
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: e0141266-e0141266
  • DOI: 10.1371/journal.pone.0141266
  • Peer Reviewed / Open Access
• [Journal Article] Gender differences in impact of CYP2C19 polymorphism on development of coronary artery disease. (2015)
  • Author(s): Hokimoto S, Tabata N, Akasaka T, Arima Y, Kaikita K, Morita K, Kumagae N, Oniki K, Nakagawa K, Ogawa H.
  • Journal Title: J. Cardiovasc. Pharmacol. Volume: 65 Issue: 2 Pages: 148-152
  • DOI: 10.1097/fjc.0000000000000171
  • Peer Reviewed
• [Journal Article] Possible association between moderate intellectual disability and weight gain in valproic acid-treated patients with epilepsy. (2015)
  • Author(s): Tanamachi Y, Saruwatari J, Noai M, Kamihashi R, Soraoka H, Yoshimori, Ogusu N, Oniki K, Yasui-Furukori N, Ishitsu T, Nakagawa K.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: -
  • Peer Reviewed
• [Journal Article] Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight. (2015)
  • Author(s): Morita K, Saruwatari J, Tanaka T, Oniki K, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Diabetes & Metabolism Volume: 41 Issue: 1 Pages: 91-94
  • DOI: 10.1016/j.diabet.2014.04.009
  • Peer Reviewed
• [Journal Article] A case of repetitive and simultaneous stent thromboses. (2015)
  • Author(s): Sueta D, Hokimoto S, Enomoto K, Ono T, Tabata T, Kajiwara I, Kaikita K, Saruwatari J, Oniki K, Nakagawa K, Ogawa H.
  • Journal Title: International Journal of Cardiology Volume: 186 Pages: 210-212
  • DOI: 10.1016/j.ijcard.2015.03.217
  • Peer Reviewed
• [Journal Article] Safety analysis of zolpidem in elderly subjects 80 years of age or older: Adverse event monitoring in Japanese subjects. (2015)
  • Author(s): Kajiwara A, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Morita K, Oniki K, Saruwatari J, Nakagawa K.
  • Journal Title: Aging Ment Health Volume: -
  • Peer Reviewed
• [Journal Article] 性差による薬物の副作用発現 (2015)
  • Author(s): 中川和子，梶原彩文．
  • Journal Title: 日本臨牀 Volume: 73 Pages: 581-585
• [Journal Article] Younger Females Are at Greater Risk of Vasodilation-Related Adverse Symptoms Caused by Dihydropyridine Calcium Channel Blockers: Results of a Study of 11,918 Japanese Patients (2014)
  • Author(s): A. Kajiwara, J. Saruwatari, (他 8名,最後)
  • Journal Title: Clin. Drug Investig. Volume: 34 Issue: 6 Pages: 431-435
  • DOI: 10.1007/s40261-014-0191-4
  • Peer Reviewed
• [Journal Article] Impact of CYP2C19 polymorphism on clinical outcome following coronary stenting is more important in non-diabetic than diabetic patients. (2014)
  • Author(s): Mizobe M, Hokimoto S, Akasaka T, Arima Y, Kaikita K, Morita K, Miyazaki H, Oniki K, Nakagawa K, Ogawa H.
  • Journal Title: Thromb. Res. Volume: 134 Issue: 1 Pages: 72-77
  • DOI: 10.1016/j.thromres.2014.04.020
  • Peer Reviewed
• [Journal Article] Impact of CYP3A5 polymorphism on platelet reactivity at percutaneous coronary intervention and after 9 months of aspirin and clopidogrel therapy in Japanese patients with coronary artery disease. (2014)
  • Author(s): Hokimoto S, Chitose T, Mizobe M, Akasaka T, Arima Y, Kaikita K, Iwashita S, Morita K, Miyazaki H, Oniki K, Matsui K, Nakagawa K, Ogawa H.
  • Journal Title: Eur. J. Clin. Pharmacol. Volume: 70 Issue: 6 Pages: 667-673
  • DOI: 10.1007/s00228-014-1672-3
  • Peer Reviewed
• [Journal Article] Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients. (2014)
  • Author(s): Morita K, Miyazaki H, Saruwatari J, Oniki K, Kumagae N, Tanaka T, Kajiwara A, Otake K, Ogata Y, Arima Y, Hokimoto S, Ogawa H, Nakagawa K.
  • Journal Title: Toxicology Letters Volume: 232 Issue: 1 Pages: 221-225
  • DOI: 10.1016/j.toxlet.2014.11.014
  • Peer Reviewed
• [Journal Article] Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. (2014)
  • Author(s): Ogusu N, Saruwatari J, Nakashima H, Noai M, Nishimura M, Deguchi M, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagaswa K.
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e111066-e111066
  • DOI: 10.1371/journal.pone.0111066
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chronic kidney disease status modifies the association of CYP2C19 polymorphism in predicting clinical outcomes following coronary stent implantation. (2014)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Arima Y, Kaikita K, Kumagae N, Morita K, Miyazaki H, Oniki K, Nakagawa K, Matsui K, Ogawa H.
  • Journal Title: Thromb. Res. Volume: 134 Issue: 5 Pages: 939-944
  • DOI: 10.1016/j.thromres.2014.07.039
  • Peer Reviewed
• [Journal Article] Comparison of the effect of CYP2C19 polymorphism on clinical outcome between acute coronary syndrome and stable angina (2014)
  • Author(s): Yuichiro Arima, Seiji Hokimoto, Tomonori Akasaka, Koichi Mizobe, Koichi Kaikita, Kentaro Oniki, Kazuko Nakagawa, Hisao Ogawa
  • Journal Title: Journal of cardiology Volume: 14 Issue: 6 Pages: 221-224
  • DOI: 10.1016/j.jjcc.2014.07.016
  • Peer Reviewed
• [Journal Article] A possible association of sex hormone-binding globulin with weight gain in the valproic acid-treated female patients with epilepsy. (2014)
  • Author(s): Saruwatari J, Uchiyashiki Y, Kajiwara A, Noai M, Tanamachi Y, Soraoka H, Deguchi M, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K.
  • Journal Title: Int J Clin Pharmacol Ther. Volume: 3 Pages: 106-110
  • Peer Reviewed
• [Presentation] バルプロ酸を服用する若年てんかん患者の肥満に及ぼすCYP2C19遺伝子多型の検討 (2015)
  • Author(s): 猿渡淳二、野相まどか、空岡裕美、梶原彩文、棚町有紀子、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 第36回日本臨床薬理学会学術総会
  • Place of Presentation: 京王プラザホテル，新宿区，東京都
  • Year and Date: 2015-12-09
• [Presentation] 核内受容体及びP450 oxidoreductaseの遺伝子多型を考慮したカルバマゼピンの母集団薬物動態解析 (2015)
  • Author(s): 松田和樹、猿渡淳二、津田義之、吉田志保、大楠直樹、吉田昂佑、今村元紀、小野達昌、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 第36回日本臨床薬理学会学術総会
  • Place of Presentation: 京王プラザホテル，新宿区，東京都
  • Year and Date: 2015-12-09
• [Presentation] 非アルコール性脂肪性肝疾患予防のための非肥満者におけるPNPLA3遺伝子変異の意義 (2015)
  • Author(s): 鬼木健太郎，武藤奈瑠美，守田和憲，居塚智子，梶原彩文，坂田美咲，北愛矢菜，熊谷直樹，大竹宏治，緒方康博，中川和子，猿渡淳二
  • Organizer: 第25回日本医療薬学会年会
  • Place of Presentation: パシフィコ横浜，横浜市，神奈川県
  • Year and Date: 2015-11-21
• [Presentation] 糖尿病における血管障害の性差に関する臨床的検討 (2015)
  • Author(s): 河田優希，梶原彩文，鬼木健太郎，北愛矢菜，坂本優季，大﨑夏海，宮川春奈，坂田美咲，守田和憲，猿渡淳二，吉田陽，井島廣子，宮本文夫，杉山正悟，稗島州雄，栗並昇，陣内冨男，梶原敬三，陣内秀昭，中川和子
  • Organizer: 第37回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 熊本大学薬学部，熊本市，熊本県
  • Year and Date: 2015-11-19
• [Presentation] 抑肝散が健康成人男性の薬物代謝酵素活性に及ぼす影響 (2015)
  • Author(s): 空岡裕美, 松田和樹, 小野達昌, 内屋敷佳弘, 上橋諒子, 北愛矢菜, 高嶋綾佳, 鬼木健太郎, 門脇大介, 宮田敬士, 中川和子, 猿渡淳二
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル，新宿区，東京都
  • Year and Date: 2015-10-29
• [Presentation] The impact of aldehyde dehydrogenase 2 polymorphism on the incidence and progression of lifestyle disease (2015)
  • Author(s): Kazunori Morita, Kentaro Oniki, Seiji Hokimoto, Junji Saruwatari, Akira Yoshida, Hideaki Jinnouchi, Koji Otake, Yasuhiro Ogata, Hisao Ogawa and Kazuko Nakagawa
  • Organizer: International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
  • Place of Presentation: Oe Campus of Kumamoto University ，熊本市，熊本県
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] KCNQ1遺伝子多型 (rs2237892) が2型糖尿病の臨床経過に及ぼす影響 (2015)
  • Author(s): 坂本優季, 鬼木健太郎, 梶原彩文, 河田優希, 守田和憲, 大﨑夏海, 益田菜月, 猿渡淳二, 中川和子, 吉田陽, 井島廣子, 宮本文夫, 杉山正悟, 稗島州雄, 栗並昇, 陣内冨男, 梶原敬三, 陣内秀昭
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール，下関市，山口県
  • Year and Date: 2015-05-21
• [Presentation] 2型糖尿病患者の冠動脈疾患発症における性差の検討 (2015)
  • Author(s): 河田優希, 梶原彩文, 北愛矢菜, 坂本優季, 大﨑夏海, 宮川春奈, 坂田美咲, 守田和憲, 鬼木健太郎, 猿渡淳二, 中川和子, 吉田陽, 井島廣子, 宮本文夫, 杉山正悟, 稗島州雄, 栗並昇, 陣内冨男, 梶原敬三, 陣内秀昭
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール，下関市，山口県
  • Year and Date: 2015-05-21
• [Presentation] Hepatocyte nuclear factor-1A遺伝子変異と肥満が2型糖尿病に及ぼす影響 (2015)
  • Author(s): 守田和憲, 田中雄大, 益田菜月, 宮川春奈, 坂田美咲, 梶原彩文, 北愛矢菜, 河田優希, 鬼木健太郎, 猿渡淳二, 中川和子, 吉田陽, 陣内秀昭, 大竹宏治, 緒方康博
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール，下関市，山口県
  • Year and Date: 2015-05-21
• [Presentation] Glutathione S-transferase K1遺伝子変異が肥満及び非アルコール性脂肪性肝疾患に及ぼす影響 (2015)
  • Author(s): 鬼木健太郎, 居塚智子, 守田和憲, 坂田美咲, 梶原彩文, 北愛矢菜, 熊谷直樹, 田中雄大, 河田優希, 猿渡淳二, 中川和子, 渡邊丈久, 吉田陽, 陣内秀昭, 大竹宏治, 緒方康博
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール，下関市，山口県
  • Year and Date: 2015-05-21
• [Presentation] Associations among γ-glutamyltransferase (GGT) 1 genotype, serum GGT level and risk of acute coronary syndrome (2015)
  • Author(s): Tanaka T, Morita K, Oniki K, Kajiwara A, Arima Y, Hokimoto S, Ogawa H, Nakagawa K.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪，大阪市，大阪府
  • Year and Date: 2015-04-24
• [Presentation] Interactive effects of aldehyde dehydrogenase 2*2 allele and current-smoking on the risk of myocardial infarction and hypertriglyceridemia (2015)
  • Author(s): Morita K, Oniki K, Tanaka T, Kajiwara A, Ogata Y, Arima Y, Hokimoto S, Ogawa H, Nakagawa K.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪，大阪市，大阪府
  • Year and Date: 2015-04-24
• [Presentation] Sex Differences in the Risk of Coronary Artery Disease among Patients with Type 2 Diabetes (2015)
  • Author(s): Kajiwara A, Morita K, Tanaka T, Oniki K, Jinnouchi H, Nakagawa K.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪，大阪市，大阪府
  • Year and Date: 2015-04-24
• [Presentation] Age-related Association of a Glutathione S-transferase K1 Polymorphism (rs1917760) with Visceral Obesity and Non-alcoholic Fatty Liver Disease (2015)
  • Author(s): Oniki K, Morita K, Tanaka T, Kajiwara A, Arima Y, Hokimoto S, Ogawa H, Ogata Y, Nakagawa K.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪，大阪市，大阪府
  • Year and Date: 2015-04-24
• [Presentation] 個別化投与設計を目指した抗てんかん薬バルプロ酸の治療効果に関する母集団薬物動態?薬力学解析 (2015)
  • Author(s): 中嶋洋生、猿渡淳二、大楠直樹、野相まどか、西村美紀、小野達昌、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫医療大学，神戸市，兵庫県
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] gamma-glutamyltransferase 1遺伝子多型と喫煙が急性冠症候群に及ぼす影響 (2015)
  • Author(s): 田中雄大、守田和憲、鬼木健太郎、猿渡淳二、熊谷直樹、益田菜月、有馬勇一郎、掃本誠治、小川久雄、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館，和歌山市，和歌山県
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Aldehyde dehydrogenase 2遺伝子多型が慢性閉塞性肺疾患に及ぼす影響 (2015)
  • Author(s): 益田菜月、守田和憲、熊谷直樹、鬼木健太郎、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館，和歌山市，和歌山県
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] γ-glutamyltransferase 1遺伝子多型と喫煙が慢性閉塞性肺疾患に及ぼす影響 (2015)
  • Author(s): 守田和憲、益田菜月、田中雄大、熊谷直樹、鬼木健太郎、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: アバローム紀の国，和歌山市，和歌山県
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Aldehyde dehydrogenase 2 遺伝子多型が生活習慣病に及ぼす影響～循環器疾患及び肺疾患に関する検討～ (2014)
  • Author(s): 守田和憲、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、掃本誠治、小川久雄、大竹宏治、緒方康博、中川和子
  • Organizer: 第17回Aldh2ノックアウトマウス学会
  • Place of Presentation: アバンセ，佐賀市，佐賀県
  • Year and Date: 2014-11-28
• [Presentation] 知的障害がバルプロ酸服用患者の肥満に及ぼす影響 (2014)
  • Author(s): 棚町有紀子、猿渡淳二、野相まどか、大楠直樹、吉田志保、吉森友紀、出口真理子、上橋諒子、中嶋洋生、鬼木健太郎、古郡規雄、兼子直、石津棟暎、中川和子
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会
  • Place of Presentation: 名古屋国際会議場，名古屋，愛知県
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] Female sex is an independent risk factor for diabetic microangiopathies in Japanese patients: Exploring possible mechanisms (2014)
  • Author(s): Ayami Kajiwara, Ayana Kita, Junji Saruwatari, Hiroko Miyazaki, Kazunori Morita, Kentaro Oniki, Akira Yoshida, Hideaki Jinnouchi, Kazuko Nakagawa
  • Organizer: 7th International Symposium: Safety and Health in Agricultural and Rural Populations: Global Perspectives
  • Place of Presentation: Delta Bessborough Hotel & Sheraton Cavalier Hotel，Saskatoon，Canada
  • Year and Date: 2014-10-19 – 2014-10-22
• [Presentation] γ-glutamyltransferase 1遺伝子多型が2型糖尿病患者の血管合併症に及ぼす影響 (2014)
  • Author(s): 田中雄大、守田和憲、河田優希、梶原彩文、北愛矢菜、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター，岡山市，岡山県
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] 肥満者の生活習慣病予防におけるβ3-adrenergic receptor遺伝子型の意義 (2014)
  • Author(s): 熊谷直樹、鬼木健太郎、守田和憲、宮崎裕子、益田菜月、大﨑夏海、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター，岡山市，岡山県
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] Aldehyde dehydrogenase 2遺伝子多型が生活習慣病の発症・進展に及ぼす影響 (2014)
  • Author(s): 守田和憲、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、掃本誠治、小川久雄、大竹宏治、緒方康博、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター，岡山市，岡山県
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] Cytochrome P450 2C19遺伝子多型が糖尿病網膜症に及ぼす影響 (2014)
  • Author(s): 梶原彩文、北愛矢菜、上橋諒子、内屋敷佳弘、守田和憲、宮川春奈、坂田美咲、野相まどか、鬼木健太郎、猿渡淳二、中川和子、吉田陽、岩下薫子、井島廣子、宮本文夫、杉山正悟、稗島州雄、陣内冨男、梶原敬三、陣内秀昭
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: リ－ガロイヤルホテル，大阪市，大阪府
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Glutathione S-transferase K1遺伝子変異が冠動脈疾患患者の腎機能低下に及ぼす影響 (2014)
  • Author(s): 居塚智子、鬼木健太郎、守田和憲、宮崎裕子、梶原彩文、北愛矢菜、熊谷直樹、田中雄大、河田優希、猿渡淳二、中川和子、吉田陽、陣内秀昭、掃本誠治、小川久雄
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: リ－ガロイヤルホテル，大阪市，大阪府
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] β3-adrenergic receptor遺伝子型の肥満及び肥満関連疾患予防における意義 (2014)
  • Author(s): 鬼木健太郎、熊谷直樹、守田和憲、梶原彩文、坂田美咲、北愛矢菜、宮崎裕子、居塚智子、河田優希、田中雄大、坂本優季、猿渡淳二、中川和子、 吉田陽、陣内秀昭、大竹宏治、緒方康博
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: ＮＣＢホテル，大阪市，大阪府
  • Year and Date: 2014-05-22 – 2014-05-24