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Studies on pollution in ecological biota caused by halogenated organic compounds originating from pharmaceuticals

Research Project

Project/Area Number 26410195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Green/Environmental chemistry
Research InstitutionIwate University

Principal Investigator

TERASAKI Masanori  岩手大学, 人文社会科学部, 准教授 (10363904)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords生物蓄積 / 塩素化パラベン / 代謝物 / 消毒副生成物 / 生物汚染 / 生物蓄積性 / 代謝変換 / 酵母レポータージーンアッセイ / 芳香族炭化水素受容体 / 生物試料 / 微量分析 / 有機塩素化合物
Outline of Final Research Achievements

In the present study, the levels of exposure to chlorinated parabens originating from pharmaceuticals in the aquatic biota (Medaka, Trichoptera, and Sinotaia quadrata histrica) were analyzed.
In the river biota investigated, 3 chlorinated and 1 non-chlorinated parabens were identified in Medaka and Trichoptera. In exposure testing of caged S. histrica near the outfall of the sewage treatment plant, 8 chlorinated and 3 non-chlorinated parabens were identified. This suggests that the sewage treatment plant is the predominant route for the accumulation of chlorinated parabens in biota.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] In Vitro transformation of chlorinated parabens by the liver S9 fraction: kinetics, metabolite identification, and aryl hydrocarbon Receptor agonist activity2016

    • Author(s)
      M Terasaki , T Wada, A. Nagashima, M Makino, H. Yasukawa
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 印刷中

    • NAID

      130005154414

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment2015

    • Author(s)
      M Terasaki, M Yasuda, M Makino, K Shimoi
    • Journal Title

      Environmental Science Water Research & Technology

      Volume: 1 Issue: 3 Pages: 375-382

    • DOI

      10.1039/c5ew00047e

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 東北地方で問題になっている有害化学物質2016

    • Author(s)
      寺崎正紀
    • Organizer
      第19回日本水環境学会シンポジウム
    • Place of Presentation
      秋田県立大学秋田キャンパス(秋田県秋田市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and endocrine-disruption potential of biotransformation products of chlorinated parabens2015

    • Author(s)
      T Wada, M Terasaki
    • Organizer
      SETAC North America 36th Annual Meeting
    • Place of Presentation
      Salt Lake City, UT, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 魚類中の防腐剤パラベンおよびその塩素化体の分析法に関する検討2015

    • Author(s)
      寺崎 正紀
    • Organizer
      第49回日本水環境学会年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Research-status Report
  • [Remarks] http://envchem.hss.iwate-u.ac.jp/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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