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Effects of rare earth ions on biological systems

Research Project

Project/Area Number 26420718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionIwate University

Principal Investigator

Wakabayashi Tokumitsu  岩手大学, 理工学部, 助教 (30332498)

Co-Investigator(Kenkyū-buntansha) 山本 歩  八戸工業高等専門学校, その他部局等, 准教授 (60523800)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords希土類金属 / 抗菌活性 / 抗カビ活性 / 抗線虫活性 / 金属ストレス / ストレス応答 / 重金属ストレス / MAPキナーゼ / 希土類 / 抗菌金属 / 抗カビ金属 / 鉄鋼スラグ / レア・アース / 低毒性
Outline of Final Research Achievements

Despite the name, rare earth elements are relatively abundant in soil. Therefore, these elements might interact with biosphere during the history of life. In this study, we have examined the effect of rare earth ions on the growth of bacteria, fungi, and soil nematode. All rare earth ions, except radioactive promethium that we have not tested, showed antibacterial and antifungal activities comparable to that of copper ions, which is widely used as antibacterial metals in our daily life. Since the rare earth ions did not show high toxicity to the human lymphoblastoid cell line or even stimulated the growth of the cultured cells at 1 mM, raising the possibility that we can substitute rare earth elements for the antibacterial metals usually used because of their safety.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Antibacterial, antifungal and nematicidal activities of rare earth ions.2016

    • Author(s)
      Wakabayashi, T., Yamamoto, A., Kazaana, A., Nakano, Y., Nojiri, Y., Kashiwazaki, M.
    • Journal Title

      Biological Trace Element Research

      Volume: 174 Issue: 2 Pages: 464-470

    • DOI

      10.1007/s12011-016-0727-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] レアアースの遺伝毒性評価と抗菌材としての可能性の検討2016

    • Author(s)
      柏崎萌子、風穴彰、中野裕太、野尻祐衣、山本歩、若林篤光
    • Organizer
      日本環境変異原学会 第45回大会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 希土類元素の有効利用の検討2016

    • Author(s)
      柏崎萌子、風穴彰、若林篤光、山本歩
    • Organizer
      化学工学会第17回学生発表会
    • Place of Presentation
      八戸工業高等専門学校(青森県八戸市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 希土類元素の抗菌素材としての可能性の検討2015

    • Author(s)
      柏崎萌子、風穴彰、若林篤光、山本歩
    • Organizer
      平成27年度東北地区高等専門学校専攻科産学連携シンポジウム
    • Place of Presentation
      仙台高等専門学校広瀬キャンパス(宮城県仙台市)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] レア・アースの線虫に対する毒性と 線虫のレア・アースに対する忌避行動2014

    • Author(s)
      若林篤光 中野裕太 野尻結衣 渡辺美和 冨田浩史
    • Organizer
      日本動物学会東北支部会
    • Place of Presentation
      岩手大学工学部
    • Year and Date
      2014-07-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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