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Roles of cannabinoid-dependent plasticity in the developing neuronal circuit in the mouse barrel cortex

Research Project

Project/Area Number 26430022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionSaitama Medical University

Principal Investigator

Chiaki Itami  埼玉医科大学, 医学部, 講師 (90392430)

Co-Investigator(Kenkyū-buntansha) 木村 文隆  大阪大学, 医学系研究科, 准教授 (00202044)
Research Collaborator LU Hui-chen  インディアナ大学, 教授
HUANG J-Y  インディアナ大学, 研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords体性感覚野 / スパイクタイミング可塑性8(STDP) / カンナビノイド / スパイクタイミング可塑性 / CB1受容体 / バレル皮質 / STDP / LTD / 臨界期 / スパイクタイミング依存性可塑性 / カンナビノイド受容体 / 活動依存性 / シナプス刈り込み
Outline of Final Research Achievements

Activation of cannabinoid CB1 receptors (CB1Rs) causes both physiological and morphological effects on the development of neuronal circuits. In the rodent barrel cortex, CB1R is required for the long-term depression (LTD) component of spike timing-dependent plasticity (STDP). We showed that CB1R activation caused LTD in a spike timing-dependent manner (t-LTD) at thalamocortical terminals. Since CB1R knockout (KO) mice showed disrupted thalamocortical projection, we concluded that endogenous CB1R signalling is important in translating physiological changes into morphological consequences.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine/Indiana University(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Developmental switch in spike timing-dependent plasticity and cannabinoid-dependent reorganization of the thalamocortical projection in the barrel cortex.2016

    • Author(s)
      Itami C, Huang JY, Yamasaki M, Watanabe M, Lu H, Kimura F
    • Journal Title

      J Neurosci,

      Volume: 36 Issue: 26 Pages: 7039-7054

    • DOI

      10.1523/jneurosci.4280-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concurrently induced plasticity due to convergence of distinct forms of spike timing-dependent plasticity in the developing barrel cortex.2016

    • Author(s)
      Itami C, Kimura F
    • Journal Title

      Eur J Neurosci.

      Volume: 44 Issue: 12 Pages: 2984-2990

    • DOI

      10.1111/ejn.13431

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met.2015

    • Author(s)
      Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T, Yamawaki S, Takahashi M, Shiosaka S, Itami C, Uegaki K, Saarma M, Kojima M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 112 Pages: 3074-3074

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Physiological and morphological roles of endocannabinoid 2-arachidonoylglycerol2016

    • Author(s)
      Itami C, Sakimura K, Kano M , Kimura F
    • Organizer
      Society for Neuroscience, 2016 (46th Annual meeting)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of endocannabinoid 2-arachdonoylglycerol in neuronal circuit of the mouse barrel cortex2016

    • Author(s)
      Chiaki Itami, Kenhji Sakimura, Masanobu Kano, Fumitaka Kimura
    • Organizer
      Society for Neuroscience, 2016 (46th Annual meeting)
    • Place of Presentation
      San Diego, California
    • Year and Date
      2016-11-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウスのバレル皮質神経回路発達における内因性カンナビノイド、2-アラキドノイルグリセロールの役割2016

    • Author(s)
      伊丹 千晶、崎村 建司、狩野 方伸、木村 文隆
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスのバレル皮質神経回路発達における内因性カンナビノイド、2-アラキドノイルグリセロールの役割2016

    • Author(s)
      伊丹千晶、崎村建司、狩野方伸、木村 文隆
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex2016

    • Author(s)
      Kimura F, Itami C, Huang J , Yamasaki M, Watanabe M, Lu H
    • Organizer
      the 10th FENS Forum of Neuroscience
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex2016

    • Author(s)
      Chiaki Itami, J-Y Huang,Miwako Yamasaki, Masahiko Watanabe, H-C Lu, Fumitaka Kimura
    • Organizer
      FENS
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] バレル皮質2/3層カラム間水平結合のスパイクタイミング依存性可塑性(STDP)形成と4層-2/3層間STDPとの相互作用2015

    • Author(s)
      木村 文隆、伊丹 千晶
    • Organizer
      第120回 日本解剖学会総会・全国学術集会・第92回 日本生理学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Topographical precision in the thalamocortical projection mediated by cannabinoid receptor in the developing barrel cortex2014

    • Author(s)
      Chiaki Itami, Jui-Yeng Huang, Hui-Chen Lu, Fumitaka Kimura
    • Organizer
      Society for Neuroscience, 2014 (44th Annual meeting)
    • Place of Presentation
      Washington, DC., USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] カンナビノイドを介したスパイクタイミング依存性可塑性の相互作用による投射制御2014

    • Author(s)
      木村 文隆、伊丹 千晶、J-E Huang、山崎 美和子、渡辺 雅彦、H-C Lu
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 発達期バレル皮質におけるカンナビノイド受容体を介した部位特異的視床皮質投射2014

    • Author(s)
      伊丹千晶, 木村 文隆
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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