Roles of cannabinoid-dependent plasticity in the developing neuronal circuit in the mouse barrel cortex
Project/Area Number |
26430022
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Saitama Medical University |
Principal Investigator |
Chiaki Itami 埼玉医科大学, 医学部, 講師 (90392430)
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Co-Investigator(Kenkyū-buntansha) |
木村 文隆 大阪大学, 医学系研究科, 准教授 (00202044)
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Research Collaborator |
LU Hui-chen インディアナ大学, 教授
HUANG J-Y インディアナ大学, 研究員
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 体性感覚野 / スパイクタイミング可塑性8(STDP) / カンナビノイド / スパイクタイミング可塑性 / CB1受容体 / バレル皮質 / STDP / LTD / 臨界期 / スパイクタイミング依存性可塑性 / カンナビノイド受容体 / 活動依存性 / シナプス刈り込み |
Outline of Final Research Achievements |
Activation of cannabinoid CB1 receptors (CB1Rs) causes both physiological and morphological effects on the development of neuronal circuits. In the rodent barrel cortex, CB1R is required for the long-term depression (LTD) component of spike timing-dependent plasticity (STDP). We showed that CB1R activation caused LTD in a spike timing-dependent manner (t-LTD) at thalamocortical terminals. Since CB1R knockout (KO) mice showed disrupted thalamocortical projection, we concluded that endogenous CB1R signalling is important in translating physiological changes into morphological consequences.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met.2015
Author(s)
Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T, Yamawaki S, Takahashi M, Shiosaka S, Itami C, Uegaki K, Saarma M, Kojima M
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Journal Title
Proc Natl Acad Sci U S A
Volume: 112
Pages: 3074-3074
Related Report
Peer Reviewed
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