| Project/Area Number |
26430035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Fujita Hirofumi 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (60725901)
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| Co-Investigator(Kenkyū-buntansha) |
杉原 泉 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60187656)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小脳 / 自閉症スペクトラム障害 / マウス / マーモセット / Pcdh10 / 比較解剖 / 神経発生 / 神経回路 / 形成過程 / プルキンエ細胞 / 小葉 |
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| Outline of Final Research Achievements |
Cerebellar lobules VI-VII are closely related to autism spectrum disorder syndrome (ASD). We analyzed structure, development and axonal projection patterns of these lobules in primates and rodents. Crus I and crus II lobules, which are the hemispheric part of lobules VI-VII, are well-developed in the primate cerebellum. We demonstrated that a combination of both of crus I and crus II in the primate is homologous only to the lobule that is defined as crus I in the rodent. Crus I of the rodent cerebellum contained large Pcdh10-positive compartments and had specific axonal projection patterns. Furthermore, transverse growth of Pcdh10-positive compartments occurred specifically in the developing lobules VI-VII and crus I. These results support the uniqueness of structure and input-output axonal projections of lobules VI-VII and crus I of the mammalian cerebellum.
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