| Project/Area Number |
26430041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Toho University |
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Principal Investigator |
HOSHI Hideo 東邦大学, 医学部, 助教 (30568382)
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| Co-Investigator(Kenkyū-buntansha) |
狩野 修 東邦大学, 医学部, 講師 (20459762)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Fumi 東邦大学, 医学部, 教授 (60205961)
TACHIBANA Masao 東京大学, 大学院人文社会系心理学, 名誉教授 (60132734)
TAMALU Fuminobu 埼玉医科大学, 医学部, 助教 (70337541)
UMINO Osamu 東邦大学, 理学部, 教授 (70119907)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 神経節細胞 / 網膜 / ギャップ結合 |
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| Outline of Final Research Achievements |
We identified one type of ganglion cell in the goldfish retina which had a large and elongated dendritic field. As a population, all of these ganglion cells were oriented in the horizontal axis and perpendicular to the dorsal-ventral axis of the goldfish eye in the central part of retina. The circuit elements which synapse with this ganglion cell are not yet characterized. We found that thisganglion cell was directly tracer coupled only with homologous ganglion cells. Cx35/36 may contribute to their gap junction. We further illustrated that the processes of dopaminergic neuron terminated next to intersections between processes of ganglion cells, close to where dopamine D1 receptors were localized. Finally, we showed that Mb1 ON bipolar cells had ribbon synapses in the axonal processes passing through the IPL and made ectopic synapses with this ganglion cell that stratified into stratum 1 of the IPL. Totally taken, we identified a new retinal ganglion cell and specific retinal circuit.
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