| Project/Area Number |
26430056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWAKI Toru 九州大学, 大学院・医学研究院, 教授 (40221098)
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| Research Collaborator |
KITAGAWA Reika 九州大学, 大学院・医学系学府
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | グリオーマ / 腫瘍幹細胞 / 代謝 / エピジェネティクス / 脂質代謝 / 糖代謝 / 免疫組織化学 / 細胞培養 / ウェスタンブロッティング / 遺伝子発現解析 |
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| Outline of Final Research Achievements |
Malignant gliomas are brain tumors resistant to multimodal therapy, representing the most malignant class of tumor in human. In the present study, we investigated metabolic state of malignant glioma cells to understand biological nature of the tumor and gain a clue to novel therapeutic approach. We found that both synthesis and utilization of lipids are increased in the tumor cells to contribute to the malignant nature. When we applied metoformin, a drug regulating metabolism, to the glioma cells, drastic changes were observed not only in metabolic state but also in the chemical modification of gene expression (epigenetics). These results indicate that the biological characteristics of malignant gliomas are dependent of crosstalk between metabolism and epigenetics.
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