Functional analyses of TCTP in neural stem/progenitor cells
| Project/Area Number |
26430074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
Ohta Shigeki 慶應義塾大学, 医学部(信濃町), 講師 (20365406)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経幹細胞 / グリオーマ幹細胞 / TCTP1 / ＴＣＴＰ１ / グリオーマ / エピジェネティクス / 再生医療 / ＴＣＴＰ1 |
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| Outline of Final Research Achievements |
MIF (Macrophage migration inhibitory factor) was identified as a functional molecule, which supports the proliferation of murine neural stem/progenitor cells (NSPCs). We also identified a new factor TCTP1 (Tumor Protein Translationally-Controlled 1), contributing to the cell proliferation of mouse NSPCs. TCTP1 gene expression was regulated by MIF and TCTP1 gene silencing defected neurogenesis in human ES cell-derived neural stem cells (hES-NSCs). We also found that MIF-TCTP1-miR338-SMO signaling cascade regulated the cell proliferation in hES-NSCs. In addition, TCTP1 supported the glioma-initiating cell proliferation regulated by MIF.
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Report
(4 results)
Research Products
(5 results)
