Functional analysis of long non-coding using a mouse model
| Project/Area Number |
26430087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOBAYASHI Shin 東京医科歯科大学, 難治疾患研究所, 非常勤講師 (10397664)
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| Co-Investigator(Kenkyū-buntansha) |
幸田 尚 東京医科歯科大学, 難治疾患研究所, 准教授 (60211893)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エピジェネティクス / non-coding RNA / 疾患モデル動物 / long non-codingRNA |
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| Outline of Final Research Achievements |
Long non-coding RNAs（lncRNA）are thought to be involved in various biological processes, but their functions in vivo largely remain to be elucidated. Here, we showed that targeted deletion of Fat60 lncRNA causes abnormal development, which resembles a human disease. Our results indicate that a functional loss of lncRNA abolishes proper development, suggesting that lncRNA could be a cause for human genetic disease.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Reply to Ferlazzo and Foray: About the Space Pup project.2017
Author(s)
Wakayama S, Kamada Y, Yamanaka K, Kohda T, Suzuki H, Shimazu T, Tada MN, Osada I, Nagamatsu A, Kamimura S, Nagatomo H, Mizutani E, Ishino F, Yano S, Wakayama T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114(33)
Issue: 33
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny2017
Author(s)
Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F, Kubota T, Wakana S.
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Journal Title
Genes & Nutrition
Volume: 12
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer.2014
Author(s)
Kamimura S, Hatanaka, Y, Hirasawa,R Matsumoto K, Oikawa, M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A
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Journal Title
Biology of Reproduction
Volume: 91
Issue: 5
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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