| Project/Area Number |
26430089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
塩見 雅志 神戸大学, 医学研究科, 准教授 (50226106)
石田 達郎 神戸大学, 医学研究科, 特命教授 (00379413)
于 イン 神戸大学, 医学研究科, 講師 (30644942)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 急性冠症候群 / 疾患モデル / 冠動脈硬化 / WHHLMI / 冠攣縮 / WHHLMIウサギ / ACS |
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| Outline of Final Research Achievements |
Acute coronary syndrome (ACS) is a life-threaten disease for mainly middle-aged men. Although prevention of ACS is one of the most important task for human beings, a lack of an appropriate animal model for this disease is a barrier for the development of its prevention. We tried to develop the animal model for ACS and we’ve established the experimental model for mimicking the initiation of ACS, i.e., coronary plaque injury, in the coronary arteries of live animals. It is expected that this model may contribute to the evaluation of novel drugs for prevention of ACS.
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