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Development of the novel in vivo model for acute coronary syndrome

Research Project

Project/Area Number 26430089
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionKobe University

Principal Investigator

Koike Tomonari  神戸大学, 医学研究科, 助教 (40432158)

Co-Investigator(Kenkyū-buntansha) 塩見 雅志  神戸大学, 医学研究科, 准教授 (50226106)
石田 達郎  神戸大学, 医学研究科, 特命教授 (00379413)
于 イン  神戸大学, 医学研究科, 講師 (30644942)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords急性冠症候群 / 疾患モデル / 冠動脈硬化 / WHHLMI / 冠攣縮 / WHHLMIウサギ / ACS
Outline of Final Research Achievements

Acute coronary syndrome (ACS) is a life-threaten disease for mainly middle-aged men. Although prevention of ACS is one of the most important task for human beings, a lack of an appropriate animal model for this disease is a barrier for the development of its prevention. We tried to develop the animal model for ACS and we’ve established the experimental model for mimicking the initiation of ACS, i.e., coronary plaque injury, in the coronary arteries of live animals. It is expected that this model may contribute to the evaluation of novel drugs for prevention of ACS.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (3 results)

  • [Journal Article] High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris-like symptoms due to coronary spasm in WHHLMI rabbits.2016

    • Author(s)
      Koike T, Tamura S, Yu Y, Kuniyoshi N, Shiomi M
    • Journal Title

      Experimental animals

      Volume: 65 Pages: 419-426

    • NAID

      120006394612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 冠動脈病変が冠スパズムおよび狭心症発症に及ぼす影響、WHHLMIウサギを用いた実験的検証2014

    • Author(s)
      田村姿央理、小池智也、ユウイン、塩見雅志
    • Organizer
      第124回関西実験動物研究会
    • Place of Presentation
      京都大学楽友会館
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris due to coronary spasm in WHHLMI rabbits2014

    • Author(s)
      Ying Yu, Tomonari Koike, Tatsuro Ishida, Satoshi Yamada, Shiori Tamura, Nobue Kuniyoshi, Ken-ichi Hirata, Masashi Shiomi
    • Organizer
      The 2nd Sino-Japan Rabbit Model Meeting
    • Place of Presentation
      Jilin University, China
    • Year and Date
      2014-08-08
    • Related Report
      2014 Research-status Report
  • [Remarks] 動物実験施設の研究成果 (WHHL/WHHLMIウサギに関する研究)

    • URL

      http://www.med.kobe-u.ac.jp/iea/gaiyou.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 動物実験施設の研究成果(WHHL/WHHLMIウサギに関する研究)

    • URL

      http://www.med.kobe-u.ac.jp/iea/gaiyou.html

    • Related Report
      2015 Research-status Report
  • [Remarks] WHHL/WHHLMIウサギのページ, 神戸大学大学院医学研究科附属動物実験施設

    • URL

      http://www.med.kobe-u.ac.jp/iea/gaiyou.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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