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Drinking behavior modulation significantly prevent cardiac remodeling and improve survival in chronic heart failure rats

Research Project

Project/Area Number 26430103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Zheng Can  国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (50443495)

Co-Investigator(Kenkyū-buntansha) 李 梅花  国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (60443496)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsChronic heart failure / Drinking behavior / Thirst / Fluid restriction / Survival / 心不全 / 飲水行動 / 渇き / 血行動態 / 生存率
Outline of Final Research Achievements

Given the lack of knowledge about fluid intake regulation and its consequences in patients with chronic heart failure (CHF), current guidelines do not provide clear direction for fluid management. This study aim to investigate altering drinking behaviors and explored fluid management strategies in a rat model of CHF. We observed that the spontaneous per drinking volume (PDV) was significantly increased in rats with myocardial infarction (MI). There was a significant inverse correlation between the PDV at the second-week post-MI and the post-MI lifespan. Modulating the drinking behavior of rats with MI to involve frequent drinking of small PDVs significantly prevented cardiac remodeling, with a significant improved prognosis. These results suggest that increment of PDV may be a prognostic vicious factor after MI, and increasing the drinking frequency, with small PDVs, may be beneficial for preventing progression of cardiac dysfunction in CHF.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Less invasive and inotrope-reduction approach to automated closed-loop control of hemodynamics in decompensated heart failure.2015

    • Author(s)
      Uemura K, Kawada T, Zheng C, Sugimachi M.
    • Journal Title

      IEEE Trans Biomed Eng

      Volume: Nov 11. [Epub ahead of print] Issue: 8 Pages: 1-10

    • DOI

      10.1109/tbme.2015.2499782

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities.2015

    • Author(s)
      Uemura K, Inagaki M, Zheng C, Li M, Kawada T, Sugimachi M.
    • Journal Title

      Heart Vessels.

      Volume: 30 Issue: 4 Pages: 516-526

    • DOI

      10.1007/s00380-014-0525-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.2014

    • Author(s)
      Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
    • Journal Title

      Eur J Heart Fail

      Volume: 16 Issue: 10 Pages: 1056-1065

    • DOI

      10.1002/ejhf.164

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Correlation of Thirst and the Prognosis in Chronic Heart Failure Rats2017

    • Author(s)
      C. Zheng, M. Li, T. Kawada, M. Inagaki, K. Uemura, M. Sugimachi
    • Organizer
      第81回 日本循環器学会学術集会
    • Place of Presentation
      金沢,日本
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prognostic significance of thirst augmentation in chronic heart failure rats2016

    • Author(s)
      C. Zheng, M. Li, T. Kawada, M. Inagaki, K. Uemura, M. Sugimachi
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drinking behavioral and hemodynamic responses to daily fluid restriction in chronic heart failure rats2016

    • Author(s)
      C. Zheng, M. Li, T. Kawada, M. Sugimachi
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early donepezil administration as a novel therapy for improved myocardial salvage after reperfused myocardial infarction2016

    • Author(s)
      M. Li, C. Zheng, T. Kawada, M. Inagaki, K. Uemura, T. Shishido, M. Sugimachi
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Central donepezil infusion prevents progression of cardiac remodeling and dysfunction in chronic heart failure rats with extensive myocardial infarction2016

    • Author(s)
      M. Li, C. Zheng, T. Kawada, M. Inagaki, K. Uemura, T. Shishido, M. Sugimachi
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Central Donepezil Infusion Prevents Progression of Cardiac Remodeling and Improves Long-term Survival in Chronic Heart Failure Rats with Myocardial Infarction2016

    • Author(s)
      Meihua, Li
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      (Sendai International Center Exhibition Building, 1F, Meeting Room 2
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Augmented Thirst as a Clue for Fluid Management in Chronic Heart Failure2015

    • Author(s)
      Can, Zheng
    • Organizer
      BIT’s 7th Annual International Congress of Cardiology
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Central donepezil infusion prevents progression of cardiac remodeling and dysfunction in chronic heart failure rats with extensive myocardial infarction2015

    • Author(s)
      Meihua, Li
    • Organizer
      欧州心臓学会(ESC2015)
    • Place of Presentation
      Lodon, English
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ロサルタンによる心筋梗塞ラットの水代謝の是正及び心臓リモデリングの抑制効果􁴾2015

    • Author(s)
      鄭 燦
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ドネペジルの早期投与による再灌流心筋梗塞ラットにおける心臓リモデリングの抑制作用2015

    • Author(s)
      李梅花
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Losartan Increases Urine Output and Dose not Affects Thirst and Fluid Consumption in Heart Failure Rats2015

    • Author(s)
      Zheng C, Li M, Kawada T, Uemura K, Inagaki M, Sugimachi M
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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