Elucidation of the gene variation accumulation mechanism in the tumor developmental process using HTLV -1 humanized mouse
| Project/Area Number |
26430126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
Yao Jinchun
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 / ヒト化マウス / Tax / APOBEC / APOBEC３ / CD25 / ウイルス感染 / インターフェロン |
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| Outline of Final Research Achievements |
An ATL-like condition of a patient onset process had been already accepted with the HTLV-1 infection humanized mouse and was intended that I clarified the instruction mechanism of the APOBEC3B gene that an expression instruction was confirmed in that.
As for the expression instruction of APOBEC3B, the participation of the virus product except Tax was thought about regardless of onset of Tax at the continuation infection in the neoplasia process whereas a rise in expression of APOBEC3B was observed with Tax expression at the initial infection to a humanized mouse. In addition, because APOBEC3B expression was controlled than a comparison between HAM patient specimen and physically unimpaired person result, an expression instruction of APOBEC3B was recognized by the instructions such as anti-HTLV-1 infection replies, and it was suggested that the variation of the host gene was accumulated.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] An enzyme-linked immunosorbent assay-based system for determining the physiological level of poly(ADP-ribose)in cultured cells.2016
Author(s)
C. Ida, S. Yamashita, M. Tsukada, T. Eguchi, M. Tanaka, S. Ogata, T. Fujii, Y. Nishi, S. Ikegami, J. Moss, M. Miwa.
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Journal Title
Anal. Biochem.
Volume: 494
Pages: 76-81
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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