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Disruption of signaling responsed to stress by HTLV-1 bZIP factor

Research Project

Project/Area Number 26430128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionTokushima Bunri University

Principal Investigator

TAKAYUKI OHSHIMA  徳島文理大学, 薬学部, 准教授 (10397557)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsウイルス / HTLV-1 / HBZ / 発がん / 翻訳後修飾 / 転写制御 / 細胞死 / ユビキチン / ヒストン修飾 / 生体防御 / オートファジー / ウイルス性発がん / 白血病 / mTOR / ATL
Outline of Final Research Achievements

Human T-cell leukemia virus type-1 (HTLV-1) infection causes adult T-cell leukemia (ATL). The viral protein HTLV-1 HBZ is thought to be associated with the development of ATL. We focused to cellular function of HBZ and defined the following two 2 points. 1), HBZ and CENP-B associate with their central regions in cells. Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells. 2), HBZ interacted with cullin 1 (CUL1) through a head-to-tail and the expression of HBZ in cells stabilized MCL1 protein expression.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Enhanced stabilization of MCL1 by HTLV-1 bZIP factor is modulated by blocking the recruitment of Cullin1 to the SCF complex.2016

    • Author(s)
      Risa Mukai, and Takayuki Ohshima
    • Journal Title

      Mol. Cell. Biol.

      Volume: 36 Pages: 3075-3085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B2015

    • Author(s)
      Mukai R and Ohshima T.
    • Journal Title

      J. Gen. Virol

      Volume: 96 Issue: 1 Pages: 159-164

    • DOI

      10.1099/vir.0.070201-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA binding ability of CENP-B2015

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Journal Title

      J. Gen. Virol.

      Volume: 96 Pages: 159-164

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm2014

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Journal Title

      Oncogene

      Volume: 33 Pages: 2317-2328

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Molecular mechanisms of HBZ-mediated MCL1 stability in HTLV-1 infected cells2017

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Organizer
      18th International Conference on Human Retrovirology HTLV and Related Viruses
    • Place of Presentation
      Tokyo
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HTLV-1 bZIP factorによるCullin1の機能抑制メカニズムの解析2015

    • Author(s)
      向井理紗、丹由香里、田中雄也、大島隆幸
    • Organizer
      第2回 日本HTLV-1学会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
  • [Presentation] HTLV-1 bZIP factor による CENP-B の機能抑制を介したヒストンメチル化制御機構の解析2014

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 62 回 日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] HTLV-1 由来産物 HBZ タンパク質による CENP-B の機能抑制メカニズムの解析2014

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 87 回 日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] CENP-B 依存的なヒストンメチル化修飾における HTLV-1 bZIP factor の役割2014

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 1 回 日本 HTLV-1 学会学術集会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2014-08-22 – 2014-08-24
    • Related Report
      2014 Research-status Report
  • [Remarks] 世界レベルで高い評価、日本人初の快挙!向井さん国際新人賞受賞

    • URL

      https://www.bunri-u.ac.jp/info/news/20160401.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 本学卒業生の向井さんが、2016年「ロレアル・ユネスコ女性科学賞-国際新人賞」を受賞しました。

    • URL

      http://kp.bunri-u.ac.jp/topics/2732.html

    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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