| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Human T-cell leukemia virus type-1 (HTLV-1) infection causes adult T-cell leukemia (ATL). The viral protein HTLV-1 HBZ is thought to be associated with the development of ATL. We focused to cellular function of HBZ and defined the following two 2 points. 1), HBZ and CENP-B associate with their central regions in cells. Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells. 2), HBZ interacted with cullin 1 (CUL1) through a head-to-tail and the expression of HBZ in cells stabilized MCL1 protein expression.
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