| Project/Area Number |
26430140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Nagumo Yoko 筑波大学, 生命環境系, 助教 (70373339)
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬剤感受性変動 / オーダーメード治療 / オーダーメイド治療 |
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| Outline of Final Research Achievements |
Cancer may recur due to the development of drug resistance, even if the regression is seen in the first drug therapy. In this study, we aimed to develop a strategy to derive a tailor-made medicine that maintains sensitivity for a longer time by analyzing the modulation that various anticancer agents give to ovarian cancer cells.
As a result of creating a drug resistant cell library, we found a tendency for cells and drugs that are easy to obtain resistance, and found a combination that could obtain a synergistic effect when used in combination with resistant drugs, or one that was more sensitive. Furthermore, from the microarray analysis, when an inhibitor of a certain gene product was used, a resistance reducing effect was observed. From the above, selection of drugs to be used for resistant cancer cells, that is, information on tailor-made medicine was obtained.
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| Academic Significance and Societal Importance of the Research Achievements |
不均一性が特に高い卵巣がんを対象に、種々の抗がん剤が、個々のがん細胞に与える変動を解析することで、薬剤耐性を得やすい細胞・薬剤や、悪性度に関する情報を得た。次に、耐性化した場合に次に処理するべき薬剤の選出、感受性にシフトさせる投薬法についての情報が得られた。以上のストラテジーは、実際のがんに応用することで、感受性を維持し悪性度の低い状態に長く留めるためのオーダーメード投薬法に寄与するものである。
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