Establishment of the photodiagnosis for cancer using small molecule metabolism elucidation in cancer cells
| Project/Area Number |
26430141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 光線力学診断 / アミノレブリン酸 / ポルフィリン / 鉄代謝 / 薬物排出トランスポーター / 低酸素 / 休眠癌細胞 / 癌幹細胞 / 薬剤排出トランスポーター |
|---|
| Outline of Final Research Achievements |
It is well known that porphyrin accumulates in cancer by the administration of aminolevulinic acid (ALA) to cancer patient and cancer diagnosis using this phenomenon is widely used. In this study, the mechanism of porphyrin accumulation is investigated. As a results, various kinds of transporters after ALA administration was important to porphyrin accumulation. Furthermore, we established the diagnostic method in cancer of difficulty treatment characteristics including hypoxic cancer or dormant cancer.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect2017
Author(s)
Takashi Kanamori, Takashi Sawamura, Tatsumi Tanaka, Izumi Sotokawa, Ryota Mori, Kotaro Inada, Akihiro Ohkubo, Shun-Ichiro Ogura, Yasutoshi Murayama, Eigo Otsuji, Hideya Yuasa
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Journal Title
Bioorganic & Medicinal Chemistry
Volume: 25
Issue: 2
Pages: 743-749
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)2017
Author(s)
Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Akiyoshi Mizumoto, Masamitu Hirano, Yuuki Imazato, Nobuyuki Takao, Masumi Ichinose, Kousuke Noguchi, Yan Li, Satoshi Wakama, Kazuhiro Yamada, Koutarou Hatano, Hiroshi Shintani, Hiroyuki Yoshitake and Shun-ichiro Ogura
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Journal Title
Cancers
Volume: 9
Issue: 3
Pages: 23-23
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Photodynamic detection of canine mammary gland tumours after oral administration of 5-aminolevulinic acid2016
Author(s)
Osaki T, Yokoe I, Ogura S, Takahashi K, Murakami K, Inoue K, Ishizuka M, Tanaka T, Li L, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y
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Journal Title
Vet Comp Onco
Volume: in press
Issue: 3
Pages: 731-739
DOI
Related Report
Peer Reviewed
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[Journal Article] Selection of patients by membrane transporter expressions for aminolevulinic acid (ALA)-guided photodynamic detection of peritoneal metastases2015
Author(s)
Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Kazuyoshi Takeshita, Akiyoshi Mizumoto, Masamitu Hirano, Nobuyuki Takao, Masumi Ichinose, Yan Li, Shun-ichiro Ogura
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Journal Title
International Journal of Sciences
Volume: 4
Issue: 09
Pages: 66-77
DOI
Related Report
Peer Reviewed
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[Journal Article] 5-aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines2015
Author(s)
Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro Ogura, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa and Tohru Tanaka
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Journal Title
Bioscience Biotechnology and Biochemistry
Volume: 79
Issue: 3
Pages: 422-431
DOI
Related Report
Peer Reviewed
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