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Establishment of the photodiagnosis for cancer using small molecule metabolism elucidation in cancer cells

Research Project

Project/Area Number 26430141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnostics
Research InstitutionTokyo Institute of Technology

Principal Investigator

Ogura Shun-ichiro  東京工業大学, 生命理工学院, 准教授 (90343160)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords光線力学診断 / アミノレブリン酸 / ポルフィリン / 鉄代謝 / 薬物排出トランスポーター / 低酸素 / 休眠癌細胞 / 癌幹細胞 / 薬剤排出トランスポーター
Outline of Final Research Achievements

It is well known that porphyrin accumulates in cancer by the administration of aminolevulinic acid (ALA) to cancer patient and cancer diagnosis using this phenomenon is widely used. In this study, the mechanism of porphyrin accumulation is investigated. As a results, various kinds of transporters after ALA administration was important to porphyrin accumulation. Furthermore, we established the diagnostic method in cancer of difficulty treatment characteristics including hypoxic cancer or dormant cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (64 results)

All 2017 2016 2015 2014 Other

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 11 results,  Acknowledgement Compliant: 8 results) Presentation (38 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation2017

    • Author(s)
      Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI and Taga T
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42070-42070

    • DOI

      10.1038/srep42070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect2017

    • Author(s)
      Takashi Kanamori, Takashi Sawamura, Tatsumi Tanaka, Izumi Sotokawa, Ryota Mori, Kotaro Inada, Akihiro Ohkubo, Shun-Ichiro Ogura, Yasutoshi Murayama, Eigo Otsuji, Hideya Yuasa
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25 Issue: 2 Pages: 743-749

    • DOI

      10.1016/j.bmc.2016.11.050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid-induced protoporphyrin IX for high-grade gliomas: A prospective case study and clinical implications2017

    • Author(s)
      Junkoh Yamamoto, Shingo Kaneda, Tetsuya Yoneda, Shun-ichiro Ogura, Shohei Shimajiri, Tohru Tanaka, Yukinori Korogi and Shigeru Nishizawa
    • Journal Title

      Oncology Letters

      Volume: 13 Issue: 3 Pages: 1269-1275

    • DOI

      10.3892/ol.2016.5539

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)2017

    • Author(s)
      Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Akiyoshi Mizumoto, Masamitu Hirano, Yuuki Imazato, Nobuyuki Takao, Masumi Ichinose, Kousuke Noguchi, Yan Li, Satoshi Wakama, Kazuhiro Yamada, Koutarou Hatano, Hiroshi Shintani, Hiroyuki Yoshitake and Shun-ichiro Ogura
    • Journal Title

      Cancers

      Volume: 9 Issue: 3 Pages: 23-23

    • DOI

      10.3390/cancers9030023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy2016

    • Author(s)
      Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 36478-36478

    • DOI

      10.1038/srep36478

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 5-aminolevulinic acid fluorescence in detection of peritoneal metastases2016

    • Author(s)
      Yutaka Yonemura, Emel Canbay, Haruaki Ishibashi, Eisei Nishino, Yoshio Endo, Shouzou Sako and Shun-ichiro Ogura
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 17 Issue: 4 Pages: 2271-2275

    • DOI

      10.7314/apjcp.2016.17.4.2271

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Photodynamic detection of canine mammary gland tumours after oral administration of 5-aminolevulinic acid2016

    • Author(s)
      Osaki T, Yokoe I, Ogura S, Takahashi K, Murakami K, Inoue K, Ishizuka M, Tanaka T, Li L, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y
    • Journal Title

      Vet Comp Onco

      Volume: in press Issue: 3 Pages: 731-739

    • DOI

      10.1111/vco.12213

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker2015

    • Author(s)
      Urara Ota, Hideo Fukuhara, Masahiro Ishizuka, Fuminori Abe, Chiaki Kawada, Kenji Tamura, Tohru Tanaka, Keiji Inoue, Shun-ichiro Ogura and Taro Shuin
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 3 Pages: 797-801

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effect of 5-aminolevulinic acid on cytochrome P450-mediated prodrug activation2015

    • Author(s)
      Mai Miura, Kensuke Ito, Maiko Hayashi, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 7 Pages: e0131793-e0131793

    • DOI

      10.1371/journal.pone.0131793

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effect of coatings on the affinity of lanthanide nanoparticles to MKN45 and HeLa cancer cells and improvement in photodynamic therapy efficiency2015

    • Author(s)
      Takashi Sawamura, Tatsumi Tanaka, Hiroyuki Ishige, Masayuki Iizuka, Yasutoshi Murayama, Eigo Otsuji, Akihiro Ohkubo, Shun-ichiro Ogura, Hideya Yuasa
    • Journal Title

      International Journal of Molecular Science

      Volume: 16 Issue: 9 Pages: 22415-22424

    • DOI

      10.3390/ijms160922415

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer.2015

    • Author(s)
      Wei S, Fukuhara H, Kawada C, Kurabayashi A, Furihata M, Ogura S, Inoue K, Shuin T
    • Journal Title

      Pathobiology.

      Volume: 82(5) Issue: 5 Pages: 224-232

    • DOI

      10.1159/000439027

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia2015

    • Author(s)
      Shimpei Otsuka, Kentaro Matsumoto, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 12 Pages: e0146026-e0146026

    • DOI

      10.1371/journal.pone.0146026

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selection of patients by membrane transporter expressions for aminolevulinic acid (ALA)-guided photodynamic detection of peritoneal metastases2015

    • Author(s)
      Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Kazuyoshi Takeshita, Akiyoshi Mizumoto, Masamitu Hirano, Nobuyuki Takao, Masumi Ichinose, Yan Li, Shun-ichiro Ogura
    • Journal Title

      International Journal of Sciences

      Volume: 4 Issue: 09 Pages: 66-77

    • DOI

      10.18483/ijsci.802

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5-aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines2015

    • Author(s)
      Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro Ogura, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa and Tohru Tanaka
    • Journal Title

      Bioscience Biotechnology and Biochemistry

      Volume: 79 Issue: 3 Pages: 422-431

    • DOI

      10.1080/09168451.2014.975186

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photodynamic therapy using upconversion nanoparticles prepared by laser ablation in liquid2015

    • Author(s)
      Tomohiro Ikehata, Yuji Onodera, Takashi Nunokawa, Tomohisa Hirano, Shun-ichiro Ogura, Toshiaki Kamachi, Osamu Odawara and Hiroyuki Wada
    • Journal Title

      Applied Surface Science

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5-Aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo2015

    • Author(s)
      Junkoh Yamamoto, Shun-ichiro Ogura, Shohei Shimajiri, Yoshiteru Nakano, Daisuke Akiba, Takehiro Kitagawa, Kunihiro Ueta, Tohru Tanaka and Shigeru Nishizawa
    • Journal Title

      Molecular Medicine Reports

      Volume: in press Issue: 3 Pages: 1813-1819

    • DOI

      10.3892/mmr.2014.2991

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia2015

    • Author(s)
      Kentaro Matsumoto, Yuichiro Hagiya, Yoshio Endo, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 12 Issue: 1 Pages: 45-51

    • DOI

      10.1016/j.pdpdt.2014.12.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid2015

    • Author(s)
      Maiko Hayashi, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 3 Pages: e0122351-e0122351

    • DOI

      10.1371/journal.pone.0122351

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis2014

    • Author(s)
      Yuta Sugiyama, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      Oncology Reports

      Volume: 31 Issue: 3 Pages: 1282-1286

    • DOI

      10.3892/or.2013.2945

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man : report of a case2014

    • Author(s)
      Canbay E, Ishibashi H, Sako S, Kitai T, Nishino E, Hirano M, Mizumoto A, Endo Y, Ogura S, Yonemura Y
    • Journal Title

      Surg Today

      Volume: 44(2) Issue: 2 Pages: 373-377

    • DOI

      10.1007/s00595-013-0500-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation2014

    • Author(s)
      Kohei Yamashita, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 347-352

    • DOI

      10.1016/j.fob.2014.03.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cytoreductive surgery under aminolevulinic acid-mediated photodynamic diagnosis plus hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from ovarian cancer and primary peritoneal carcinoma: Results of a Phase I trial2014

    • Author(s)
      Yang Liu, Yoshio Endo, Takuji Fujita, Haruaki Ishibashi, Toshihiro Nishioka, Emel Canbay, Yan Li, Shun-ichiro Ogura and Yutaka Yonemura
    • Journal Title

      Annals of Surgical Oncology

      Volume: 21 Issue: 13 Pages: 4256-4262

    • DOI

      10.1245/s10434-014-3901-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 5-アミノレブリン酸を用いるがん光線力学的療法に対する耐性化機構2017

    • Author(s)
      遠藤 良夫、 宇都 義浩、安部 千秋、小倉 俊一郎、米村 豊
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリア鉄プールによるIRP2発現の制御2016

    • Author(s)
      佐々木龍太、大塚慎平、小倉俊一郎
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノレブリン酸を用いたC6グリオーマ幹細胞の検出に対する鉄キレート剤による向上効果2016

    • Author(s)
      王文茜、椨康一、萩谷祐一郎、室田吉貴、小倉俊一郎、田賀哲也
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 5-アミノレブリン酸を用いるがん光線力学療法に対する耐性化機構2016

    • Author(s)
      遠藤良夫、宇都義浩、安部千秋、小倉俊一郎、米村豊
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 5-アミノレブリン酸を用いた光線力学療法に対する酸素の重要性2016

    • Author(s)
      大塚慎平、松本健太郎、小倉俊一郎
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘム生成がWarburg効果に与える影響2016

    • Author(s)
      高橋英里香、大塚慎平、小倉俊一郎
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞におけるミトコンドリア鉄量とその関連タンパク質発現の解析2016

    • Author(s)
      佐々木龍太、大塚慎平、小倉俊一郎
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノレブリン酸(ALA)が拓く医療 ~がんの診療からミトコンドリアの活性化まで~2016

    • Author(s)
      小倉俊一郎
    • Organizer
      第19回 生命化学研究会
    • Place of Presentation
      ホテル西長門リゾート
    • Year and Date
      2016-08-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Mechanism of porphyrin metabolism in cancer spheroid after administration of 5-aminolevulinic acid2015

    • Author(s)
      Taku Nakayama, Kentaro Matsumoto, Tohru Tanaka, Ichiro Okura, Shun-ichiro Ogura
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of 5-aminolevulinic acid on cytochrome P450-based prodrug activation2015

    • Author(s)
      Mai Miura, Kensuke Ito, Maiko Hayashi, Tohru Tanaka, Ichiro Okura, Shun-ichiro Ogura
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of electron transport chain on the production of PpIX in hypoxia2015

    • Author(s)
      Shimpei Otsuka, Kentaro Matsumoto, Tohru Tanaka, Ichiro Okura, Shun-ichiro Ogura
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of iron ion on the specificity of photodynamic therapy using 5-aminolevulinic acid (ALA)2015

    • Author(s)
      Shun-ichiro Ogura,Maiko Hayashi, Hideo Fukuhara,Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アミノレブリン酸添加後の光照射が種々の遺伝子発現応答に与える影響2015

    • Author(s)
      小林竜也、大塚慎平、山下晃平、中島元夫、田中徹、小倉俊一郎
    • Organizer
      第38回日本分子生物学会年回、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 高密度培養によるプロトポルフィリンIX蓄積促進機構の解明2015

    • Author(s)
      岡島穂高、中山沢、大塚慎平、中島元夫、田中徹、小倉俊一郎
    • Organizer
      第38回日本分子生物学会年回、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] アミノレブリン酸添加後の腫瘍特異的ポルフィリン蓄積2015

    • Author(s)
      小倉俊一郎
    • Organizer
      第38回日本分子生物学会年回、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 5-アミノレブリン酸添加後の腫瘍特異的ポルフィリン蓄積メカニズムの解明2015

    • Author(s)
      小倉俊一郎
    • Organizer
      第36回 日本レーザー医学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 3次元培養がん細胞におけるアミノレブリン酸添加後のポルフィリン代謝解析2015

    • Author(s)
      中山沢、松本健太郎、小倉俊一郎
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 低酸素環境におけるPpIX蓄積に対する電子伝達系の影響2015

    • Author(s)
      大塚慎平、松本健太郎、中山沢、小倉俊一郎
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 5-アミノレブリン酸添加後の腫瘍特異的ポルフィリン蓄積メカニズムの解明2015

    • Author(s)
      小倉俊一郎
    • Organizer
      第25回日本光線力学学会学術総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 低酸素環境におけるPpIX蓄積に対する電子伝達系の影響2015

    • Author(s)
      大塚慎平、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第13回がんとハイポキシア研究会
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 低酸素環境におけるPpIX蓄積に対する電子伝達系の影響2015

    • Author(s)
      大塚慎平、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第5回ポルフィリン-ALA学会
    • Place of Presentation
      早稲田大学西早稲田キャンパス
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ミトコンドリア新生および活性化に対するアミノレブリン酸・レスベラトロールの添加効果2015

    • Author(s)
      三浦舞、杉山雄太、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第5回ポルフィリン-ALA学会
    • Place of Presentation
      早稲田大学西早稲田キャンパス
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
  • [Presentation] がん細胞スフェロイドにおけるアミノレブリン酸添加後のポルフィリン代謝解析2015

    • Author(s)
      中山沢、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第5回ポルフィリン-ALA学会
    • Place of Presentation
      早稲田大学西早稲田キャンパス
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ミトコンドリア新生および活性化に対するアミノレブリン酸・レスベラトロールの添加効果2015

    • Author(s)
      三浦舞、杉山雄太、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] アミノレブリン酸(ALA)を利用したがん治療における低酸素の役割の解明2015

    • Author(s)
      大塚慎平、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] がん細胞スフェロイドにおけるアミノレブリン酸添加後のポルフィリン代謝解析2015

    • Author(s)
      中山沢、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Tumor-specific porphyrin accumulation and tumor screening after administration of aminolevulinic acid2014

    • Author(s)
      Shun-ichiro Ogura, Yuichiro Hagiya, Ichiro Okura
    • Organizer
      21th International SPACC Symposium
    • Place of Presentation
      Kogakuin University, Shinjuku
    • Year and Date
      2014-10-31 – 2014-11-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Based Prodrug Activation2014

    • Author(s)
      Mai Miura、Kensuke Ito、Maiko Hayashi、Tohru Tanaka、Ichiro Okura、Shun-ichiro Ogura
    • Organizer
      21th International SPACC Symposium
    • Place of Presentation
      Kogakuin University, Shinjuku
    • Year and Date
      2014-10-31 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of iron ion on the photodynamic therapy using 5-aminolevulinic acid2014

    • Author(s)
      Maiko Hayashi, Tohru Tanaka, Ichiro Okura, Shun-ichiro Ogura
    • Organizer
      21th International SPACC Symposium
    • Place of Presentation
      Kogakuin University, Shinjuku
    • Year and Date
      2014-10-31 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Analysis of the role of hypoxia in 5-aminolevulinic acid(ALA)-based tumor therapy and diagnosis2014

    • Author(s)
      Shimpei Otsuka, Kentaro Matsumoto, Shun-ichiro Ogura
    • Organizer
      21th International SPACC Symposium
    • Place of Presentation
      Kogakuin University, Shinjuku
    • Year and Date
      2014-10-31 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] The mechanism of porphyrin metabolism in cancer spheroid after administration of 5-aminolevulinic acid2014

    • Author(s)
      Taku Nakayama, Kentaro Matsumoto, Tohru Tanaka, Ichiro Okura, Shun-ichiro Ogura
    • Organizer
      21th International SPACC Symposium
    • Place of Presentation
      Kogakuin University, Shinjuku
    • Year and Date
      2014-10-31 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] アミノレブリン酸を用いた光線力学療法における鉄イオンの役割2014

    • Author(s)
      林麻衣子、井上啓史、福原秀雄、執印太郎、小倉俊一郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] がん細胞スフェロイドにおけるアミノレブリン酸添加後のポルフィリン代謝解析2014

    • Author(s)
      中山沢、松本健太郎、小倉俊一郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] シトクロムP450を介したプロドラッグ活性化に対するアミノレブリン酸の添加効果2014

    • Author(s)
      三浦舞、伊藤謙介、林麻衣子、小倉俊一郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] アミノレブリン酸投与後の腫瘍特異的ポルフィリン蓄積機構の解明2014

    • Author(s)
      小倉 俊一郎、萩谷 祐一郎、中島 元夫、田中 徹
    • Organizer
      第8回バイオ関連化学シンポジウム
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] アミノレブリン酸を用いた光線力学療法における鉄の添加効果2014

    • Author(s)
      林麻衣子 、福原秀雄、井上啓史 、執印太郎 、田中徹 、大倉一郎 、小倉俊一郎
    • Organizer
      日本鉄バイオサイエンス学会第38回学術集会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Presentation] シトクロムP450を介したプロドラッグ活性化に対するアミノレブリン酸の添加効果2014

    • Author(s)
      三浦舞、伊藤謙介、林麻衣子、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第4回ポルフィリン-ALA学会
    • Place of Presentation
      ニチイ学館・神戸ポートアイランドセンター
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] がん細胞スフェロイドにおけるアミノレブリン酸添加後のポルフィリン代謝解析2014

    • Author(s)
      中山沢、松本健太郎、田中徹、大倉一郎、小倉俊一郎
    • Organizer
      第4回ポルフィリン-ALA学会
    • Place of Presentation
      ニチイ学館・神戸ポートアイランドセンター
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Book] 5-アミノレブリン酸の科学と医療応用2015

    • Author(s)
      ポルフィリンALA学会
    • Total Pages
      198
    • Publisher
      東京化学同人
    • Related Report
      2015 Research-status Report
  • [Remarks] 小倉研究室ホームページ

    • URL

      http://www.ogura.bio.titech.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京工業大学 小倉研究室

    • URL

      http://www.ogura.bio.titech.ac.jp/

    • Related Report
      2015 Research-status Report
  • [Remarks] 東京工業大学 生命理工学研究科 小倉研究室

    • URL

      http://www.ogura.bio.titech.ac.jp/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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