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The evaluation of suppressive effects for suppression of tumor metastasis using retrovirally introduced antitumor cytokine, IL-24 into prostate cancer cells.

Research Project

Project/Area Number 26430169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionKitasato University

Principal Investigator

Kitasato Hidero  北里大学, 医療衛生学部, 教授 (90195256)

Co-Investigator(Kenkyū-buntansha) 中村 正樹  北里大学, 医療衛生学部, 助教 (30724554)
片桐 真人  北里大学, 医療衛生学部, 教授 (50152674)
馬嶋 正隆  北里大学, 医学部, 教授 (70181641)
松本 和将  北里大学, 医学部, 講師 (70306603)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsインターロイキン24 / 抗腫瘍性サイトカイン / IL-24 / 細胞治療
Outline of Final Research Achievements

In this study, antitumor effects such as cell proliferation inhibition, apoptosis induction and epithelial marker elevation, were significantly observed in retrovirally IL-24 introduced into prostate cancer defecting IL-24 receptors. Interestingly, those effects were not observed by administration of recombinant IL-24 to the prostate cancer cells. The detail of mechanism for the antitumor effects by introduced IL-24 may dissolve in the future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2014

All Presentation (2 results)

  • [Presentation] Interleukin-24により前立腺がん細胞に対する抗腫瘍効果の検討とその作用機序の解析2016

    • Author(s)
      松本優汰、前花祥太郎、中村正樹、小島史章、北里英郎
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都府京都市 左京区岡崎成勝寺町9-1京都市勧業館「みやこめっせ」
    • Related Report
      2016 Annual Research Report
  • [Presentation] IL-24産生遺伝子改変細胞を用いた悪性黒色腫に対する抗腫瘍効果の検討2014

    • Author(s)
      中村綾香,香川理紗,前花祥太郎,中村正樹,北里英郎
    • Organizer
      第35回 日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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