Characterization of golgins in secretion and Golgi
| Project/Area Number |
26440055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Okayama University |
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Principal Investigator |
Satoh Ayano 岡山大学, 自然科学研究科, 准教授 (40303002)
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| Research Collaborator |
Nishino Kunihiko
Nishino Mitsuko (Hayashi Mitsuko)
Nishina Yuta
Yu Sidney
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ゴルジ体 / 分泌 / 電子線トモグラフィー / ノックダウン / ゴルジン / 小分子化合物 / 細胞内輸送 / 阻害剤 |
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| Outline of Final Research Achievements |
We have shown that secretion increases and the structure of the Golgi changes when knocking down giantin, which is one of the Golgin protein group. In this research project, to clarify the molecular mechanisms underlying this phenomenon as the ultimate goal, the structure of the Golgi was analyzed in detail using electron beam tomography and the like. Also, during this time, we discovered a novel small molecule involved in secretion regulation, so we performed the characterization of new molecules, as well.
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Report
(5 results)
Research Products
(39 results)
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[Journal Article] Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.2017
Author(s)
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjyo Y, Ichinose T, Tokuno SI, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.
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Journal Title
Oncol Rep
Volume: 38
Issue: 1
Pages: 449-455
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.2017
Author(s)
Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y.
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Journal Title
Hepatology
Volume: 65
Issue: 5
Pages: 1720-1734
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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