Study of functional evolution of adrenal steroid receptor in evolutionary process
Project/Area Number |
26440159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 副腎ステロイド / ステロイドホルモン / ホルモン受容体 / 分子進化 / 電解質コルチコイド受容体 / 古代魚 / プロゲステロン / 副腎ステロイド受容体 / 分子シミュレーション |
Outline of Final Research Achievements |
The adrenal steroid receptor binds to adrenal steroids such as glucocorticoids and mineralocorticoids secreted from the adrenal cortex and is involved in the mechanism of maintaining the homeostasis of animals and endocrine secretions. However, it is still unknown at which stage of biological evolution the mechanism of maintaining endocrine homeostasis by adrenal steroid receptors found in higher vertebrates such as humans. The purpose of this research project was to clarify the process of adrenal steroid receptor gene appearance and function acquisition in evolution process. As a result, ancient fishes, gar and sturgeon have the adrenal steroid receptor genes like humans, and the adrenal steroid receptors from ancient fishes have functionally equivalent to human receptors. These results can be expected to serve as important clues to elucidate the molecular evolution of the adrenal steroid receptor.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Characterization of evolutionary trend in squamate estrogen receptor sensitivity2016
Author(s)
Yatsu R, Katsu Y, Kohno S, Mizutani T, Ogino Y, Ohta Y, Myburgh J, van Wyk JH, Guillette Jr LJ, Miyagawa S, Iguchi T.
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Journal Title
Gen Comp Endocrinol
Volume: 238
Pages: 88-95
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Molecular cloning and characterization of anti-Mullerian hormone (AMH) from the Japanese wrinkled frog, Rana rugosa.2015
Author(s)
Kodama M, Suda M, Sakamoto D, Iwasaki T, Matsuo Y, Uno Y, Matsuda Y, Nakamura Y, Maekawa S, Katsu Y, Nakamura M
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Journal Title
Endocrinology
Volume: 156
Issue: 5
Pages: 1914-1923
DOI
Related Report
Peer Reviewed
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[Journal Article] Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination2015
Author(s)
Kohno, S., Bernhard, M.C., Katsu, Y., Zhu, J., Byan, T.A., Doheny, B.M., Iguchi, T. and Guillette, L.J.Jr.
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Journal Title
Endocrinology
Volume: 印刷中
Issue: 5
Pages: 1887-1899
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification and characterization of the androgen receptor from the American alligator, Alligator mississippiensis.2015
Author(s)
Miyagawa S, Yatsu R, Kohno S, Doheny BM, Ogino Y, Ishibashi H, Katsu Y, Ohta Y, Guillette LJ Jr, Iguchi T
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Journal Title
Endocrinology
Volume: 156
Issue: 8
Pages: 2015-2037
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Understanding the molecular basisi for differences in responses of fish estrogen receptor subtypes to environmental estrogens2015
Author(s)
Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, Kobayashi T, Tyler CR, Iguchi T
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Journal Title
Environ Sci Technol
Volume: 49
Issue: 12
Pages: 7439-7447
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor2014
Author(s)
Miyagawa, S., Lange, A., Hirakawa, I., Tohyama, S., Ogino, Y., Mizutani, T., Kagami, Y., Kusano, T., Ihara, M., Tanaka, H., Tatarazako, N., Ohta, Y., Katsu, Y., Tyler, C.R. and Iguchi, T.
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Journal Title
Environ. Sci. Technol.
Volume: 未定
Issue: 9
Pages: 5254-5263
DOI
Related Report
Peer Reviewed / Open Access
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