Elucidation of epigenetic mechanisms underlying the intestinal symbiosis for improvement of intestinal environments by foods
Project/Area Number |
26450165
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Nihon University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
細野 朗 日本大学, 生物資源科学部, 教授 (70328706)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 食品機能 / 腸管上皮 / 腸内細菌 / 腸管上皮細胞 / 腸管 / 上皮細胞 / 共生細菌 |
Outline of Final Research Achievements |
To elucidate the molecular mechanisms underlying the intestinal symbiosis, epigenetic regulation of intestinal epithelial function by gut microbiota was analyzed. It was shown that gut microbiota-dependent miRNA in intestinal epithelial cells regulates intestinal epithelial permeability. It was also shown that another miRNA abundantly expressed in intestinal epithelial cells of specific intestinal portions regulates expression of a negative signaling molecule to bacterial stimuli. These results are applicable to the evaluation system for food components which keep healthy symbiotic system in the intestine.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Post-transcriptional regulation of Toll-interacting protein in the intestinal epithelium2016
Author(s)
Y. Sugi, K. Takahashi, K. Kurihara, K. Nakata, H. Narabayashi, Y. Hamamoto, M. Suzuki, M. Tsuda, S. Hanazawa, A. Hosono, S. Kaminogawa
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Journal Title
PLoS ONE
Volume: 11
Issue: 10
Pages: e0164858-e0164858
DOI
Related Report
Peer Reviewed / Open Access
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