| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
There are complex defense systems in the gastrointestinal mucosa, usually exposed to external stresses. Our previous study revealed that intracellular protease complex G-calpain (heterodimer of calpain 8 and calpain 9) expressed specifically in the gastrointestinal tract is involved in stress-responsive gastric mucosal protection, and intestinal immunity via regulation of Th17 cell differentiation, although these mechanisms are unknown. This study suggested that G-calpain acts on gastric mucosal defense by regulating migration and proliferation of mucus-secreting cells and negative regulation of gastric acid secretion, and that G-calpain activity regulates, or is regulated by, epithelial adhesion of intestinal bacteria in the intestine.
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