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The influence of maternal factors on the development of stress reactivity in dogs.

Research Project

Project/Area Number 26450433
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionJichi Medical University

Principal Investigator

Nagasawa Miho  自治医科大学, 医学部, ポスト・ドクター (70533082)

Research Collaborator SHIBATA You  麻布大学, 獣医学部
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsイヌ / 発達 / ストレス応答 / 母性因子 / コルチゾール
Outline of Final Research Achievements

We investigated the influence of maternal factors on stress reactivity and behavioral characteristics after growth in dogs. Mother dogs and their puppies who gave birth at the Japan Guide Dog Association were subjected. Urinary cortisol and maternal behavior of mother dogs were measured in order to quantify the maternal factors. Puppies' urinary cortisol levels were measured under mild isolation stress as an index of stress reactivity. Urinary cortisol was also measured when puppies entered the training center after coming back from puppy raisers, which was used as an index of stress reactivity to novel environment. We also conducted dog’s behavior and temperament assessment by trainers. As the results, we found that the maternal behavior from the mother dogs affected the puppies’ adaptability to the novel environment after growing up via the stress reactivity at the developmental periods, and also related to the temperament such as training ability and superiority after growth .

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014

All Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Acknowledgement Compliant: 6 results,  Open Access: 5 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Early weaning impairs a social contagion of pain-related stretching behavior in mice.2016

    • Author(s)
      Takefumi Kikusui, Yukino Ishio, Miho Nagasawa, Jeffrey Mogil, Kazutaka Mogi.
    • Journal Title

      Dev Psychobiol

      Volume: 58 Issue: 8 Pages: 1101-1107

    • DOI

      10.1002/dev.21443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Early weaning impairs fear extinction and decreases brain-derived neurotrophic factor expression in the prefrontal cortex of adult male C57BL/6 mice2016

    • Author(s)
      Kazutaka Mogi, Yuiko Ishida, Miho Nagasawa, Takefumi Kikusui.
    • Journal Title

      Dev Psychobiol.

      Volume: 58 Issue: 8 Pages: 1034-1042

    • DOI

      10.1002/dev.21437

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heart rate variability predicts the emotional state in dogs2016

    • Author(s)
      M. Katayama, T. Kubo, K. Mogi, K. Ikeda, M. Nagasawa, T. Kikusui
    • Journal Title

      Behavioural Processes

      Volume: 128 Pages: 108-112

    • DOI

      10.1016/j.beproc.2016.04.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Owners' direct gazes increase dogs' attention-getting behaviors2016

    • Author(s)
      Midori Ohkita, Miho Nagasawa, Mogi Kazutaka, and Takefumi Kikusui
    • Journal Title

      Behavioral Processes.

      Volume: 125 Pages: 96-100

    • DOI

      10.1016/j.beproc.2016.02.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Very Low Birth Weight Monochorionic Diamniotic Twins as a Risk Factor for Symptomatic Patent Ductus Arteriosus.2016

    • Author(s)
      Hiroshi Yamaguchi, Keiko Wada, Miho Nagasawa, Takefumi Kikusui, Hitomi Sakai, Masami Mizobuchi, Seiji Yoshimoto, Hideto Nakao
    • Journal Title

      Neonatology

      Volume: 109 Issue: 3 Pages: 228-234

    • DOI

      10.1159/000442968

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of behavioral characteristics of dogs in the United States and Japan2016

    • Author(s)
      Miho Nagasawa, Kazutaka Mogi, James Serpell, and Takefumi Kikusui
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 2 Pages: 231-238

    • DOI

      10.1292/jvms.15-0253

    • NAID

      130005131341

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris).2015

    • Author(s)
      Tonoike, A., Nagasawa, M., Mogi, K., Serpell, J. A., Ohtsuki, H., Kikusui, T.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 17710-17710

    • DOI

      10.1038/srep17710

    • NAID

      120006667789

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Copy number variations in the amylase gene (AMY2B) in Japanese native dog breeds.2015

    • Author(s)
      Tonoike, A., Hori, Y., Inoue-Murayama, M., Konno, A., Fujita, K., Nagasawa, M., Mogi, K., Kikusui, T.
    • Journal Title

      Anim. Genet.

      Volume: 46 Issue: 2 Pages: 580-583

    • DOI

      10.1371/journal.pone.0148899

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The frequency variations of the oxytocin receptor gene polymorphisms among dog breeds.2015

    • Author(s)
      Tonoike, A., Terauchi, G., Inoue-Murayama, M., Nagasawa, M., Mogi, K., Kikusui, T.
    • Journal Title

      Journal of Azabu University

      Volume: 27 Pages: 11-18

    • NAID

      120005732078

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.2015

    • Author(s)
      Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T.
    • Journal Title

      Science

      Volume: 348 Issue: 6232 Pages: 333-336

    • DOI

      10.1126/science.1261022

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intranasal administration of oxytocin promotes social play in domestic dogs.2015

    • Author(s)
      Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T
    • Journal Title

      Commun. Integr. Biol.

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice.2015

    • Author(s)
      Tatsuya Hattori, Kouta Kanno, Miho Nagasawa, Katsuhiko Nishimori, Kazutaka Mogi, and Takefumi Kikusui.
    • Journal Title

      Neuroscience Research

      Volume: 90 Pages: 90-94

    • DOI

      10.1016/j.neures.2014.05.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Frequency Variations of the Oxytocin Receptor Gene Polymorphisms among Dog Breeds.2014

    • Author(s)
      Tonoike A, Terauchi G, Inoue-Murayama M, Nagasawa M, Mogi K, Kikusui T
    • Journal Title

      麻布大学雑誌

      Volume: 76 Pages: 757-761

    • NAID

      120005732078

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sex differences in spatiotemporal expression of AR, ERα, and ERβ mRNA in the perinatal mouse brain.2014

    • Author(s)
      Kazutaka Mogi, Haruka Takanashi, Miho Nagasawa, and Takefumi Kikusui
    • Journal Title

      Neuroscience Letters

      Volume: 584 Pages: 88-92

    • DOI

      10.1016/j.neulet.2014.10.028

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face.2014

    • Author(s)
      Saito A, Hamada H, Kikusui T, Mogi K, Nagasawa M, Mitsui S, Higuchi T, Hasegawa T, Hiraki K.
    • Journal Title

      Front Neurosci.

      Volume: 8 Pages: 217-217

    • DOI

      10.3389/fnins.2014.00217

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin promotes social bonding in dogs.2014

    • Author(s)
      Romero T1, Nagasawa M2, Mogi K3, Hasegawa T4, Kikusui T3.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 25 Pages: 9085-9090

    • DOI

      10.1073/pnas.1322868111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of neonatal oxytocin manipulation on development of social behaviors in mice.2014

    • Author(s)
      Mogi, M., Ooyama, R., Nagasawa, M., Kikusui, T.
    • Journal Title

      Physiol. Behav.

      Volume: 133 Pages: 68-75

    • DOI

      10.1016/j.physbeh.2014.05.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs2014

    • Author(s)
      Nagasawa M1, Shimozawa A, Mogi K, Kikusui T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 5 Pages: 757-761

    • DOI

      10.1292/jvms.13-0351

    • NAID

      130003391262

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Developmental social environment imprints female preference for male song in mice2014

    • Author(s)
      Akari Asaba, Shota Okabe, Miho Nagasawa, Masahiro Kato, Nobuyoshi Koshida, Takuya Osakada, Kazutaka Mogi, Takefumi Kikusui.
    • Journal Title

      PloS ONE

      Volume: 9(2): e87186 Issue: 2 Pages: 1-7

    • DOI

      10.1371/journal.pone.0087186

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒトとイヌとの絆形成におけるイヌの視線利用と関連遺伝子探索について2016

    • Author(s)
      永澤美保
    • Organizer
      日本動物学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒトとイヌの絆形成2016

    • Author(s)
      永澤美保
    • Organizer
      第12回日本獣医内科学アカデミー学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ヒトとイヌとの絆形成2015

    • Author(s)
      永澤美保
    • Organizer
      日本人間行動進化学会第8回大会
    • Place of Presentation
      総合研究大学院大学葉山キャンパス
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ヒトとイヌとの絆形成について2015

    • Author(s)
      永澤美保
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Oxytocin-gaze positive loop between humans and dogs increased urinary oxytocin in humans and their dogs.2015

    • Author(s)
      Miho Nagasawa
    • Organizer
      The 11th WORLD CONGRESS of the International Society for ADAPTIVE MEDICINE
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The development of endocrine stress response in early socialization period is associated with that in adulthood in dogs.2014

    • Author(s)
      Miho Nagasawa, Yoh Shibata, Akiko Yonezawa, Tomoko Morita, Masanori Kanai, Kazutaka Mogi, Takefumi Kikusui
    • Organizer
      日本動物心理学会第74回大会
    • Place of Presentation
      犬山国際観光センター“フロイデ”
    • Year and Date
      2014-07-19 – 2014-07-21
    • Related Report
      2014 Research-status Report
  • [Book] 日本の犬 人とともに生きる2015

    • Author(s)
      菊水 健史, 永澤 美保, 外池 亜紀子, 黒井 眞器
    • Total Pages
      230
    • Publisher
      東京大学出版会
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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