| Project/Area Number |
26450436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
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| Co-Investigator(Renkei-kenkyūsha) |
MEGURO Akira 横浜市立大学, 医学研究科, 特任准教授 (60508802)
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| Research Collaborator |
ENDO Lisa
NANBA Reiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 緑内障 |
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| Outline of Final Research Achievements |
Glaucoma is a degenerative optic neuropathy that is associated with elevated intraocular pressure. We previously reported a significant association between the SRBD1 SNPs and glaucoma in humans and dogs. The purpose of this study was to clarify the contribution of SRBD1 in the development of glaucoma and we performed an in-depth of the SRBD1 gene region in several dog breeds.
In this study, we identified the intronic SNP in SRBD1 which exhibited the strongest association with glaucoma in both Shiba-Inus and Shih-Tzus. We also identified another intronic SNP showing a suggestive association with glaucoma in American Cocker Spaniels, Miniature Dachshunds, and Beagles. The functional analysis suggested that these SNPs affect gene expression of SRBD1.
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