| Project/Area Number |
26450445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Research Collaborator |
KISO Yasuo 山口大学, 共同獣医学部, 教授
KANO Kiyoshi 山口大学, 共同獣医学部, 准教授
TAKESHITA Ai 和歌山医大, 医学部, 任期付研究員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | metalloprotease / ADAM / uterine NK cells / placenta / vasodilation / angiogenesis / 胎盤 / 血管 / メタロプロテアーゼ / 子宮NK細胞 / 血管形成 / 流産 / ADAMDEC |
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| Outline of Final Research Achievements |
Existence of a disintegrin and metalloprotease-like decysin (ADAMDEC-1) has been confirmed in the mouse placenta, but their reproductive function is unclear. We examined ADAMDEC-1 regarding the distribution and appearance patterns in the normal mouse placenta and effects on the placental capillaries and epithelial cells.This study showed the possibilities that ADAMDEC-1 is produced from the uterine NK cells in mouse placentas. Uterine NK cells seemed to release ADAMDEC-1 to maternal blood circulation and transit to fetal side of placenta. ADAMDEC-1 may help placental vasodilation and angiogenesis, and promote nutritional exchanges and fetal growth in placenta.
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