| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
For the development of versatile one-pot multistep synthesis, we utilized soluble polymer. In Mannich reaction, we studied solvents, substrates, polymers, and we were able to obtain the desired compound in good yield with aqueous media, using PEG-dimethyl ether as the best polymer. Then, various substrates, reagents were tested, and we found that the figure of reaction field remarkably differed by the order of addition of substrates and reagents. In addition, the difference of the figure apparently affected the reaction yield.
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