| Project/Area Number |
26460019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
Hosoi Shinzo 京都薬科大学, 薬学部, 教授 (60209236)
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| Co-Investigator(Kenkyū-buntansha) |
山下 正行 京都薬科大学, 薬学部, 教授 (20239982)
勝本 之晶 福岡大学, 理学部, 准教授 (90351741)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 誘起円二色性 / ビナフチル / 絶対配置決定法 / ステロール / デカリン / 発色団 / 立体選択的合成 / キラリティー / 絶対配置決定 / ステロイド / ロドデノール / フェニルアルコール |
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| Outline of Final Research Achievements |
In order to enlarge the versatility of “the induced exciton coupled circular dichroism method”, we have carried out the followings. 1) The twelve chiral stereoisomers of 2-naphthalenols were prepared and the CD spectra of the corresponding binaphthyl esters were obtained. For the six stereoisomers of decahydro-4a-methyl-2-naphthalenol, the CD spectra of the binaphthyl ester derivatives show the bisignate CD signal with an expected sign, in which the positive for 2S-isomer and the negative for 2R-isomer. However, the other two isomers give rise to an opposite signal to the expectation, 2) We have applied this method to determine the absolute configuration of rhododenol, which has the melanogenesis suppressing activity. The CD spectra of the rhododenol derivatives have shown a split CD, indicating the potential application of the method proposed here.
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