| Project/Area Number |
26460084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA YUKI 神戸薬科大学, 薬学部, 助教 (40421284)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞外分泌因子 / FGF / 肝臓 / FGF21 / 脂肪酸 / 代謝 / 産生誘導 / 脂質代謝 |
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| Outline of Final Research Achievements |
FGF21, one of FGFs, markedly improves carbohydrate and lipid metabolism and is expected to be a new drug for metabolic diseases from its pharmacological action. In this study, we have shown that oral administration of linseed oil, one of the dietary oils, increased the level of serum FGF21 in mice. Treatment with a variety of non-esterified fatty acids of mice orally and of primary-cultured hepatocytes suggested that alpha-linolenic acid contained in the linseed oil could increase serum FGF21 levels. We also found that severe hepatic steatosis developed in mice fed linseed oil for 16 weeks compared with in those fed lard, maybe through the induction of FGF21. It is suggested that non-esterified fatty acids from adipocyte lipolysis induced by FGF21 may be the cause of hepatic steatosis.
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