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The roles of teh endocrine factor,Fgf21, in gastrointestinal absorption of nutrients

Research Project

Project/Area Number 26460084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

Konishi Morichika  神戸薬科大学, 薬学部, 教授 (00322165)

Co-Investigator(Renkei-kenkyūsha) MASUDA YUKI  神戸薬科大学, 薬学部, 助教 (40421284)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords細胞外分泌因子 / FGF / 肝臓 / FGF21 / 脂肪酸 / 代謝 / 産生誘導 / 脂質代謝
Outline of Final Research Achievements

FGF21, one of FGFs, markedly improves carbohydrate and lipid metabolism and is expected to be a new drug for metabolic diseases from its pharmacological action. In this study, we have shown that oral administration of linseed oil, one of the dietary oils, increased the level of serum FGF21 in mice. Treatment with a variety of non-esterified fatty acids of mice orally and of primary-cultured hepatocytes suggested that alpha-linolenic acid contained in the linseed oil could increase serum FGF21 levels. We also found that severe hepatic steatosis developed in mice fed linseed oil for 16 weeks compared with in those fed lard, maybe through the induction of FGF21. It is suggested that non-esterified fatty acids from adipocyte lipolysis induced by FGF21 may be the cause of hepatic steatosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (1 results)

  • [Journal Article] Fgf21 regulates T-cell development in the neonatal and juvenile thymus.2017

    • Author(s)
      Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M
    • Journal Title

      Scientific Reports

      Volume: 23 Issue: 1 Pages: 330-330

    • DOI

      10.1038/s41598-017-00349-8

    • NAID

      120006305890

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secreted factor, FGF21, regulates diverse biological processes2016

    • Author(s)
      Konishi M, Nakayama Y, Masuda Y
    • Journal Title

      生化学

      Volume: 88 Issue: 1 Pages: 86-93

    • DOI

      10.14952/SEIKAGAKU.2016.880086

    • NAID

      40020753611

    • ISSN
      0037-1017
    • Year and Date
      2016-02-25
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease2016

    • Author(s)
      Itoh N, Nakayama Y, Konishi M
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 4

    • DOI

      10.3389/fcell.2016.00030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy.2015

    • Author(s)
      Itoh N, Ohta H, Konishi M.
    • Journal Title

      Frontier Endocrinology (Lausanne).

      Volume: 6 Pages: 1-9

    • DOI

      10.3389/fendo.2015.00154

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid increase in fibroblast growth factor 2 in protein malnutrition and its impact on growth and lipid metabolism.2015

    • Author(s)
      Yori Ozaki, Kenji Saito, Kyoko Nakazawa, Morichika Konishi, Nobuyuki Itoh, Fumihiko Hakuno, Shin-Ichiro Takahashi, Hisanori Kato and Asako Takenaka
    • Journal Title

      British Journal of Nutrition

      Volume: 114 Issue: 9 Pages: 1410-1418

    • DOI

      10.1017/s0007114515002846

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress.2015

    • Author(s)
      Kim SH, Kim KH, Kim HK, Kim MJ, Back SH, Konishi M, Itoh N, Lee MS.
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 4 Pages: 809-818

    • DOI

      10.1007/s00125-014-3475-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 不飽和脂肪酸負荷より誘導されるFgf21の脂質代謝調節機構の解析2016

    • Author(s)
      藤岡広大,松家京介,伊藤信行,中山喜明,小西守周
    • Organizer
      第63回日本生化学会近畿支部例会
    • Place of Presentation
      神戸薬科大学
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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